Objective: To investigate the general features and distribution of Chinese medical syndrome of novel coronavirus-infected pneumonia patients in Shanghai. Methods: Fifty novel coronavirus-infected pneumonia patients from Shanghai Public Health Clinical Center were enrolled in this analysis. The epidemiological data, blood routine, chest CT, Chinese medical syndrome characteristics, tongue image and pulse information were collected on the first day of admission, and analyzed and differentiated according to Chinese Medical Diagnosis and Treatment Plan for Shanghai Novel Coronavirus-Infected Pneumonia(Trial). Results: The average age of novel coronavirus-infected pneumonia patients was about 50 years old, most of them were male, the ratio of male to female was 1.27∶1, 74% of them had the history of visiting or living in Wuhan/Hubei, 20% of them had the history of close contact with the confirmed patients. The chest CT mainly showed multi lobed lesions, no obvious abnormality in white blood cells was found, and the low level of lymphoid cells and high level of C-reactive protein were also identified. More than half of the patients showed fever( 84%),cough( 62%),fatigue( 62%),poor appetite( 58%),dry mouth( 56%),diarrhea( 56%) and spontaneous sweating( 54%). The main tongue features were light red tongue or red tongue,with greasy coat( 68%) and white coat( 74%). The main Chinese medical syndrome was dampnesstoxicity stagnation in lung( 82%),a small number of patients presented with syndrome of heat-toxicity blocking lung( 18%). The average age of patients with syndrome of dampness-toxicity stagnation in lung was significantly lower than that of patients with syndrome of heattoxicity blocking lung( P = 0.002). The proportion of male patients with syndrome of dampness-toxicity stagnation in lung was obviously higher than that with syndrome of heat-toxicity blocking lung( P = 0. 024). Conclusion: The main Chinese medical syndrome of novel coronavirus-infected pneumonia patients is dampness-toxicity stagnation in lung,which is in line with characteristics of dampness epidemic in traditional Chinese medicine.