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1.曲靖市中医医院医疗教研部(云南 曲靖 655000)
2.曲靖市中医医院骨与关节病中心(云南 曲靖 655000)
3.昆明理工大学信息工程与自动化学院(云南 昆明 650500)
4.曲靖市中医医院精准微创外科中心(云南 曲靖 655000)
何丽娟,女,硕士,药师,主要从事肿瘤药理学方面研究
罗光雄,副主任医师;E-mail:luogx9008@163.com
修回:2025-02-21,
录用:2025-02-23,
纸质出版:2025-04-30
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何丽娟,范圣益,奠佐红等.PI3K/Akt信号通路与肿瘤、血糖调节、神经系统疾病相关性研究进展[J].上海中医药大学学报,2025,39(S1):196-203.
HE Lijuan,FANG Shengyi,DIAN Zuohong,et al.Research progress on correlation between PI3K/Akt signaling pathway and tumors, blood glucose regulation and nervous system diseases[J].Academic Journal of Shanghai University of Traditional Chinese Medicine,2025,39(S1):196-203.
何丽娟,范圣益,奠佐红等.PI3K/Akt信号通路与肿瘤、血糖调节、神经系统疾病相关性研究进展[J].上海中医药大学学报,2025,39(S1):196-203. DOI: 10.16306/j.1008-861x.2025.S1.045.
HE Lijuan,FANG Shengyi,DIAN Zuohong,et al.Research progress on correlation between PI3K/Akt signaling pathway and tumors, blood glucose regulation and nervous system diseases[J].Academic Journal of Shanghai University of Traditional Chinese Medicine,2025,39(S1):196-203. DOI: 10.16306/j.1008-861x.2025.S1.045.
磷脂酰肌醇3激酶/蛋白激酶B(PI3K/Akt)是参与细胞生长、增殖、分化调节和葡萄糖转运的重要信号通路。本文旨在讨论PI3K/Akt通路调控异常在肿瘤、血糖调节、神经系统疾病的相关性,以及各类底物蛋白是如何调控的,同时总结以PI3K/Akt信号通路为靶点的各类药物研究及开发情况,为以PI3K/Akt信号通路为靶点各类药物研发提供参考。
Phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) is an important signal pathway involved in cell growth, proliferation, differentiation regulation and glucose transport. The purpose of this paper was to discuss the correlation of abnormal regulation of PI3K/Akt pathway in tumors, blood glucose regulation, nervous system diseases, and how various substrate proteins are regulated. At the same time, the research and development of various drugs targeting PI3K/Akt signal pathway are summarized, which provides a reference for the research and development of all kinds of drugs targeting PI3K/Akt signal pathway.
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