Mr. Liu Shunong （1895—1985） from Shanghai University of Traditional Chinese Medicine （TCM）， employed Marxist materialist dialectics to elucidate the scientific principles underlying TCM theory. He identified "true qi" as the essential mediating material exchanges between human life and nature， as well as the physiological activities of ascending-descending， entering-exiting metabolic processes. He expounded the embryonic form of

the unity of opposites principle in yin-yang theory and its clinical applications， analyzed the disease patterns arising from the contradiction between pathogenic factors and vital energy while emphasizing pathogen elimination as the therapeutic priority. Through exploring the intrinsic connections among classical texts including

Huangdi Neijing

（

The Yellow Emperor's Inner Canon

），

Nanjing

（

Classic of Difficulties

）， and

Shanghan Zabing Lun

（

Treatise on Cold Damage and Miscellaneous Diseases

）， he revealed the essence of TCM inheritance. His scholarship fully demonstrates a researcher

'

s ethos of seeking truth from facts and pursuing scientific veracity， along with academic insights that harmonize tradition with innovation while keeping pace with the times. This study aims to present the exploratory practice of a renowned TCM master who passed away nearly 40 years ago， providing reference for integrating Marxism with China's outstanding traditional cultural heritage.