上海交通大学医学院附属第九人民医院中医科(上海 200011)
代秋颖,女,博士,医师,主要从事中医外科学的临床和基础研究工作
廖明娟,副主任医师;E-mail: 932966846@qq.com
纸质出版日期:2024-05-25,
收稿日期:2023-07-10,
修回日期:2024-04-15,
扫 描 看 全 文
代秋颖,王永灵,李琰等.复方地榆凝胶贴膏的制备工艺及透皮实验研究[J].上海中医药大学学报,2024,38(03):66-73.
DAI Qiuying,WANG Yongling,LI Yan,et al.Study on preparation technology and transdermal experiment of compound Sanguisorbae Radix gel plaster[J].Academic Journal of Shanghai University of Traditional Chinese Medicine,2024,38(03):66-73.
代秋颖,王永灵,李琰等.复方地榆凝胶贴膏的制备工艺及透皮实验研究[J].上海中医药大学学报,2024,38(03):66-73. DOI: 10.16306/j.1008-861x.2024.03.010.
DAI Qiuying,WANG Yongling,LI Yan,et al.Study on preparation technology and transdermal experiment of compound Sanguisorbae Radix gel plaster[J].Academic Journal of Shanghai University of Traditional Chinese Medicine,2024,38(03):66-73. DOI: 10.16306/j.1008-861x.2024.03.010.
目的
2
制备复方地榆提取物凝胶贴膏剂,并研究其体外透皮性、释放特性。
方法
2
通过正交实验优化凝胶贴膏基质配比;采用Franz扩散池及半透膜进行体外经皮渗透实验及体外释放实验,以地榆的主要有效成分没食子酸为检测指标,利用高效液相色谱分析测定。
结果
2
凝胶贴膏的最优基质处方为2.5 g 聚丙烯酸钠NP700、1.5 g 聚乙烯吡咯烷酮K30(PVP-K30)、4 g羧甲基纤维素钠(CMC-Na)、1 g 卡波姆。本实验方案样品配制过程可控,重复性、稳定性、回收率良好。复方地榆凝胶贴膏主要成分没食子酸的透皮速率为4.783 μg·cm
-2
·h
-1
、释药速率为5.89 μg·cm
-2
·h
-1
。
结论
2
所制备复方地榆凝胶贴膏的基质结构与复方地榆提取物具有较好的相容性,没食子酸的释药速率高于透皮速率,皮肤屏障起到限速作用。
Objective: To prepare compound Sanguisorbae Radix extract gel plaster, and study its transdermal and release characteristics in vitro.
Methods
2
The matrix formulation of gel plaster was optimized by orthogonal experiment. Franz diffusion cells and semipermeable membrane were used for in vitro percutaneous penetration and in vitro release experiments. Taking gallic acid, the main active component of Sanguisorbae Radix, as the detection indicator, and was analyzed and determined by high-performance liquid chromatography.
Results
2
The optimal matrix formulation of gel plaster was 2.5 g sodium polyacrylate NP700, 1.5 g polyvinylpyrrolidone-K30 (PVP-K30), 4g carboxymethyl cel
lulose-Natrium (CMC-Na) and 1g carbomer. The sample preparation process of this experimental scheme was controllable, with good repeatability, stability and recovery rate. The transdermal rate of gallic acid, the main component of compound Sanguisorbae Radix gel plaster, was 4.783 μg·cm
-2
·h
-1
, and the drug release rate was 5.89 μg·cm
-2
·h
-1
.
Conclusions
2
The prepared matrix structure of the compound Sanguisorbae Radix gel plaster had good compatibility with the compound Sanguisorbae Radix extract. The drug release rate of gallic acid was higher than the transdermal rate, which means the skin barrier played a speed limiting role.
地榆凝胶贴膏中医药工艺
Sanguisorbae Radixgel plastertraditional Chinese medicinetechnology
国家药典委员会. 中华人民共和国药典[M]. 北京: 中国医药科技出版社, 2020.
Chinese Pharmacopoeia Commission. Chinese Pharmacopoeia (2020 edition)[M]. Beijing: The Medicine Science and Technology Press of China, 2020.
刘建平. 生物药剂学与药物动力学(第4版)[M]. 北京:人民卫生出版社, 2011.
LIU J P. Biopharmaceutics and Pharmacokinetics (4th edition) [M]. Beijing: People's Health Publishing House, 2011.
张传辉, 贾成友, 李微, 等. 三七接骨凝胶膏剂的制备及体外透皮特性研究[J]. 中草药, 2015, 46(5): 654-664.
ZHANG C H, JIA C Y, LI W, et al. Preparation of Sanqi Hydrogel Patch used for setting a bone and study on its transdermal permeability in vitro[J]. Chinese Traditional and Herbal Drugs, 2015, 46(5): 654-664.
张兆旺. 中药药剂学[M]. 北京:中国中医药出版社, 2017.
ZHANG Z W. Pharmacy of Chinese materia medica[M]. Beijing: China Traditional Chinese Medicine Press, 2017.
朱力阳. 丁桂凝胶膏剂的制备工艺及主要药效学研究[D]. 成都:成都中医药大学, 2016.
ZHU L Y. Study of Preparation Process and Principal Pharmacodynamics of Dinggui Gel Paste[D]. Chengdu: Chengdu University of Traditional Chinese Medicine, 2016.
段丽云, 连凤梅. 地榆的临床应用及其用量探究[J]. 长春中医药大学学报, 2021, 37(4): 749-752.
DUAN L Y, LIAN F M. Study on the clinical application and dosage of garden burnet root[J]. Journal of Changchun University of Chinese Medicine, 2021, 37(4): 749-752.
樊箫雨, 杨凯丽, 李花花, 等. Box-Behnken响应面结合基准关联度和AHP-熵权法优化经典名方半夏泻心汤的提取工艺[J]. 中草药, 2022, 53(21): 6716-6725.
FAN X Y, YANG K L, LI H H, et al. Optimization of extraction process for classical prescription Banxia Xiexin Decoction based on Box-Behnken design-response surface, standard relation and analytic hierarchy process combined with entropy method[J]. Chinese Traditional and Herbal Drugs, 2022, 53(21): 6716-6725.
杨雪颖, 杨海菊, 赵玥瑛, 等. 经典名方化肝煎的基准样品质量标准及量值传递研究[J]. 中国中药杂志, 2022, 47(15): 3994-4006.
YANG X Y, YANG H J, ZHAO Y Y, et al. Quality standard and quality value transfer of reference samples of classical prescription Huagan Decoction[J]. China Journal of Chinese Materia Medica, 2022, 47(15): 3994-4006.
楚世慈. 栀黄凝胶贴膏临床前药学研究[D]. 上海:上海中医药大学, 2021.
CHU S C. Preclinical pharmaceutical study of the prescription of Zhihuang gel paste[D]. Shanghai: Shanghai University of Traditional Chinese Medicine, 2021.
林世源, 黄慧琳, 陈卉, 等. 白花丹巴布剂的基质处方优选及其体外透皮吸收研究[J]. 中国现代应用药学, 2020, 37(16): 1963-1967.
LIN S Y, HUANG H L, CHEN H, et al. Optimization of Matrix Formulation and in Vitro Transdermal Absorption of Plumbago Zeylanica Cataplasm[J]. Chinese Journal of Modern Applied Pharmacy, 2020, 37(16): 1963-1967.
王英英, 朱洁, 鲁兰, 等. 中药地榆的成分以及其药理作用研究进展[J]. 四川中医, 2022, 40(8): 216-223.
WANG Y Y, ZHU J, LU L, et al. Advances in the Study of Components and Pharmacological Effects of Traditional Chinese Medicine Sanguisorba officinalis L[J]. Journal of Sichuan of Traditional Chinese Medicine, 2022, 40(8): 216-223.
何希瑞, 樊鹏程, 李茂星, 等. 常用止血中药及其止血机制研究进展[J]. 中国实验方剂学杂志, 2010, 16(15): 217-221.
HE X R, FAN P C, LI M X, et al. Advances in Study of Traditional Chinese Hemostyptic Drugs and Related Mechanisms[J]. Chinese Journal of Experimental Traditional Medical Formulae, 2010, 16(15): 217-221.
张蕾, 满莉, 宛春雷, 等. 地榆提取物的体外抑菌活性及机制[J]. 吉林大学学报(理学版), 2019, 57(3): 701-707.
ZHANG L, MAN L, WAN C L, et al. Antibacterial Activities and Mechanism of Extracts from Sanguisorba officinalis L. in Vitro[J]. Journal of Jilin University (Science Edition), 2019, 57(3): 701-707.
吴龙龙, 徐昊阳, 张刘强, 等. 地榆化学成分及药理作用研究进展[J]. 世界科学技术-中医药现代化, 2022, 24(1): 360-378.
WU L L, XU H Y, ZHANG L Q, et al. Research Progress on Chemical Constituents and Pharmacological Activities of Sanguisorba officinalis[J]. Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology, 2022, 24(1): 360-378.
许维国, 刘洋, 刘多见, 等. 没食子酸抑菌活性分析[J]. 中国公共卫生, 2012, 28(10): 1329-1331.
XU W G, LIU Y, LIU D J, et al. Antimicrobial activity of galic acid[J]. Chinese Journal of Public Health, 2012, 28(10): 1329-1331.
宗琪, 董丽华, 薛瑞, 等. 凝胶贴膏剂的基质及体内外评价研究进展[J]. 国际药学研究杂志, 2020, 47(10): 814-820.
ZONG Q, DONG L H, XUE R, et al. Matrix and in vivo and in vitro evaluation of cataplasma:research progress[J]. Journal of International Pharmaceutical Research, 2020, 47(10): 814-820.
韩霜, 冯松浩, 马旭伟, 等. 中药凝胶贴膏剂的研究进展及在产品开发中的应用[J]. 中草药, 2018, 49(21): 5197-5204.
HAN S, FENG S H, MA X W, et al. Research progress on Chinese materia medica gel plaster and its application in product development[J]. Chinese Traditional and Herbal Drugs, 2018, 49(21): 5197-5204.
童继军. 中药凝胶贴膏工艺研究进展[J]. 中国药业, 2020, 29(11): 96-100.
TONG J J. Research Progress of the Technology of Gel Plaster of Traditional Chinese Medicine[J]. China Pharmaceuticals, 2020, 29(11): 96-100.
杨光, 朱森发, 李文杰, 等. 基于流变学性质的辅料用量对中药凝胶贴膏成型质量影响的研究[J]. 上海中医药大学学报, 2022, 36(1): 75-84.
YANG G, ZHU S F, LI W J, et al. Effect of excipient dosage on modeling quality of gel plaster of traditional Chinese medicine based on rheological properties[J]. Academic Journal of Shanghai University of Traditional Chinese Medicine, 2022, 36(1): 75-84.
季文莹, 马晶晶, 李季文, 等. 中药凝胶贴膏研究进展[J]. 中国中医药信息杂志, 2022, 29(11): 152-156.
JI W Y, MA J J, LI J W, et al. Research Progress in TCM Gel Paste[J]. Chinese Journal of Information on Traditional Chinese Medicine, 2022, 29(11): 152-156.
陈晓文, 廖明娟. 正交试验优选地榆方中地榆的提取工艺[J]. 湖北中医药大学学报, 2021, 23(4): 45-48.
CHEN X W, LIAO M J. Optimization of extraction process of Radix Sanguisorba in Diyu Prescription by orthogonal test[J]. Journal of Hubei University of Chinese Medicine, 2021, 23(4): 45-48.
万思琦, 徐京育. 中药凝胶贴膏研究进展及问题展望[J]. 河北中医, 2019, 41(2): 305-311.
WAN S Q, XU J Y. Research progress and prospect of traditional Chinese medicine gel plaster[J]. Hebei Journal of Traditional Chinese Medicine, 2019, 41(2): 305-311.
武晏屹, 田硕, 白明, 等. 基于皮肤功能特点的药物透皮吸收新思考[J]. 世界中医药, 2020, 15(3): 361-363, 368.
WU Y Y, TIAN S, BAI M, et al. New Thinking on Drug Transdermal Absorption Based on Skin Functional Characteristics[J]. World Chinese Medicine, 2020, 15(3): 361-363, 368.
杨华生, 黎晓丽, 吴璐, 等. 中药凝胶贴膏质量研究进展与思考[J]. 中医外治杂志, 2016, 25(3): 3-5.
YANG H S, LI X L, WU L, et al. Research progress and thinking on the quality of traditional Chinese medicine gel plaster[J]. Journal of External Therapy of Traditional Chinese Medicine, 2016, 25(3): 3-5.
0
浏览量
0
下载量
0
CSCD
0
CNKI被引量
关联资源
相关文章
相关作者
相关机构