温州医科大学附属第一医院中医科(浙江 温州 325000)
单卓程,女,硕士,住院医师,主要从事中医治疗脾胃病临床研究
叶人,主任医师,硕士生导师;E-mail: yeren601@163.com
纸质出版日期:2024-03-25,
收稿日期:2023-09-10,
修回日期:2023-12-01,
扫 描 看 全 文
单卓程,叶人,袁拯忠等.柴芍汤治疗外科术后肠粘连临床疗效观察[J].上海中医药大学学报,2024,38(02):61-64.
SHAN Zhuocheng,YE Ren,YUAN Zhengzhong,et al.Observation on clinical efficacy of Chaishao Decoction in treatment of postoperative intestinal adhesion[J].Academic Journal of Shanghai University of Traditional Chinese Medicine,2024,38(02):61-64.
单卓程,叶人,袁拯忠等.柴芍汤治疗外科术后肠粘连临床疗效观察[J].上海中医药大学学报,2024,38(02):61-64. DOI: 10.16306/j.1008-861x.2024.02.009.
SHAN Zhuocheng,YE Ren,YUAN Zhengzhong,et al.Observation on clinical efficacy of Chaishao Decoction in treatment of postoperative intestinal adhesion[J].Academic Journal of Shanghai University of Traditional Chinese Medicine,2024,38(02):61-64. DOI: 10.16306/j.1008-861x.2024.02.009.
目的
2
观察柴芍汤治疗外科术后肠粘连的临床疗效。
方法
2
纳入符合标准的80例术后肠粘连患者,随机分为中药组和对照组,每组各40例。两组患者均给予西医常规支持治疗,中药组在常规治疗基础上加服柴芍汤,治疗周期均为14 d。评价两组患者的临床疗效;治疗前后比较两组患者的中医证候总积分;比较两组患者的首次排气时间、首次自主排便时间及住院时间;治疗前后检测并比较两组患者的白介素(IL)-6、IL-10水平。
结果
2
①治疗后,中药组的总有效率为90.0%,对照组为75.0%,中药组的疗效优于对照组(
P
<
0.05)。②治疗后,两组患者的中医证候总积分较治疗前均显著降低(
P
<
0.05),且中药组患者的积分显著低于对照组(
P
<
0.05)。③中药组患者的首次排气时间、首次自主排便时间及住院时间均较对照组明显缩短(
P
<
0.05)。④治疗后,两组患者的IL-6、IL-10水平较治疗前均降低(
P
<
0.05),且中药组患者的IL-6、IL-10水平低于对照组(
P
<
0.05)。
结论
2
柴芍汤结合西医常规疗法治疗术后肠粘连,能有效缓解患者的不适症状,缩短首次排便、排气时间及住院时间,降低患者的血清炎症因子水平。
Objective: To observe the clinical efficacy of Chaishao Decoction in the treatment of postoperative intestinal adhesion.
Methods
2
A total of 80 patients with postoperative intestinal adhesion who met the criteria were included and randomly divided into the traditional Chinese medicine group and the control group, 40 cases in each group. The patients in both groups were treated with conventional supportive treatment with western medicine, and the patients in the traditional Chinese medicine group were treated with Chaishao Decoction based on above. The treatment course was 14 d. The clinical efficacy of the two groups was evaluated. Before and after treatment, the total scores of traditional Chinese medicine syndromes were compared between the two groups. The time of the first exhaust, the time of the first autonomic defecation and the time of hospital stay were compared between the two groups. Before and after treatment, the levels of interleukin (IL)-6 and IL-10 were detected and compared between the two groups.
Results
2
①After treatment, the total effective rate was 90.0% in the traditional Chinese medicine group and 75.0% in the control group, and the efficacy of the traditional Chinese medicine group was better than that of the control group (
P
<
0.05). ②After treatment, the total scores of traditional Chinese medicine syndromes in both groups were significantly decreased compared with those before treatment (
P
<
0.05), and the scores of the traditional Chinese medicine group were significantly lower than those of the control group (
P
<
0.05). ③The time of the first exhaust, the time of the first autonomic defecation and the time of hospital stay in the traditional Chinese medicine group were significantly shorter than those in the control group (
P
<
0.05). ④After treatment, the levels of IL-6 and IL-10 in both groups were decreased compared with those before treatment (
P
<
0.05), and the levels of IL-6 and IL-10 in the traditional Chinese medicine group were lower than those in the control group (
P
<
0.05).
Conclusion
2
Chaishao Decoction combined with conventional western medicine can effectively relieve the discomfort symptoms in patients with postoperative intestinal adhesion, shorten the time of the first exhaust and defecation and the hospitalization time, and decrease the levels of serum inflammatory factors.
肠粘连腹腔镜术后柴芍汤中西医结合
intestinal adhesionafter laparoscopic surgeryChaishao Decoctionintegrated traditional Chinese and western medicine
樊玉青, 吴兰兰, 李永彪, 等. 中药防治术后腹腔粘连机制研究进展[J]. 中国中药杂志, 2020, 45(18): 4358-4363.
FAN Y Q, WU L L, LI Y B, et al. Research progress on mechanisms of traditional Chinese medicine in prevention and treatment of postoperative peritoneal adhesion[J]. China Journal of Chinese Materia Medica, 2020, 45(18): 4358-4363.
吴玲利, 杨利娜, 裴嫣嫣. 大承气汤保留灌肠与热奄包烫熨联合常规疗法治疗胃大部切除术后肠梗阻临床研究[J]. 新中医, 2021, 53(22): 1-5.
WU L L, YANG L N, PEI Y Y. Clinical Study on Retention Enema with Dachengqi Tang and Hot Package Ironing Combined with Routine Therapy for Intestinal Obstruction After Subtotal Gastrectomy[J]. New Chinese Medicine, 2021, 53(22): 1-5.
陈孝平, 汪建平. 外科学[M]. 9版. 北京: 人民卫生出版社, 2018: 362.
CHEN X P, WANG J P. Surgery[M]. 9th Edition. Beijing: People’s Health Publishing House, 2018: 362.
《预防腹部外科手术后腹腔粘连的中国专家共识》专家组. 预防腹部外科手术后腹腔粘连的中国专家共识[J]. 中华普通外科杂志, 2017, 32(11): 984-988.
Expert Group of Chinese Expert Consensus on the Prevention of Abdominal Adhesions after Abdominal Surgery. Chinese expert consensus on the prevention of abdominal adhesions after abdominal surgery[J]. Chinese Journal of General Surgery, 2017, 32(11): 984-988.
陈衍池. 超声诊断肠梗阻的价值分析[J]. 中国医疗器械信息, 2023, 29(14): 16-18, 176.
CHEN Y C. Value Analysis of Ultrasound for the Diagnosis of Intestinal Obstruction[J]. China Medical Device Information, 2023, 29(14): 16-18, 176.
国家中医药管理局. 中医病证诊断疗效标准[M]. 北京: 中国医药科技出版社, 2012: 20.
National Administration of Traditional Chinese Medicine. Diagnostic Efficacy Criteria for Chinese Medicine Diseases[M]. Beijing: China Medical Science Press, 2012: 20.
郑筱萸. 中药新药临床研究指导原则(试行)[M]. 北京: 中国医药科技出版社, 2002: 161-163.
ZHENG X Y. Guiding Principles for Clinical Research of New Drugs of Traditional Chinese Medicine (trial implementation)[M]. Beijing: China Medical Science Press, 2002: 161-163.
魏奇锋. 中西医结合治疗术后肠粘连的应用与有效性探析[J]. 光明中医, 2018, 33(19): 2894-2896.
WEI Q F. Discussion on the Application and Effectiveness of Integrated Traditional Chinese and Western Medicine in the Treatment of Postoperative Intestinal Adhesions[J]. Guangming Journal of Chinese Medicine, 2018, 33(19): 2894-2896.
余世万. 血府逐瘀汤联合大承气汤加减治疗术后肠粘连性腹痛临床研究[J]. 亚太传统医药, 2015, 11(16): 120-121.
YU S W. Clinical study on the treatment of postoperative intestinal adhesive abdominal pain by modified Xuefu Zhuyu Decoction combined with Dachengqi Decoction[J]. Asia-Pacific Traditional Medicine, 2015, 11(16): 120-121.
青梅, 白彦满都拉. 蒙医预防术后肠粘连研究进展[J]. 亚太传统医药, 2015, 11(8): 16-17.
QING M, BAIYAN M D L. Progress of research on prevention of postoperative intestinal adhesion in Mongolian medicine[J]. Asia-Pacific Traditional Medicine, 2015, 11(8): 16-17.
张殿尧, 吴香萍. 开腹胆囊手术与腹腔镜胆囊手术术后肠粘连发生率的比较观察[J]. 中国实用医药, 2019, 14(16): 54-55.
ZHANG D Y, WU X P. A comparative observation on the incidence of postoperative intestinal adhesions between open and laparoscopic gallbladder surgery[J]. China Practical Medicine, 2019, 14(16): 54-55.
姜凡军. 中西医结合预防肠道手术术后肠粘连的体会[J]. 中国实用医药, 2016, 11(10): 162-163.
JIANG F J. Prevention of postoperative intestinal adhesions after intestinal surgery by combining Chinese and western medicine[J]. China Practical Medicine, 2016, 11(10): 162-163.
赵立昌, 计忠宁, 夏晶晶. 当归芍药散临床应用及实验研究[J]. 河南中医, 2021, 41(5): 653-655.
ZHAO L C, JI Z N, XIA J J. Clinical Application and Experimental Research of Chinese Angelica and Peony Powder[J]. Henan Traditional Chinese Medicine, 2021, 41(5): 653-655.
0
浏览量
0
下载量
0
CSCD
0
CNKI被引量
关联资源
相关文章
相关作者
相关机构