1.上海交通大学医学院附属新华医院神经内科(上海 200092)
2.上海市第六人民医院神经内科(上海 200233)
3.上海中医药大学附属龙华医院脑病科(上海 200032)
4.上海中医药大学附属市中医医院脑病科(上海 200040)
5.上海中医药大学附属上海市中西医结合医院脑病科(上海 200082)
吴娜,女,博士,副主任医师,主要从事中西医结合诊治帕金森病的临床研究
李琳,主治医师;E-mail: lilin7505@126.com
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吴娜,陆磊,叶青等.乌灵胶囊治疗帕金森病伴睡眠障碍的多中心观察性研究[J].上海中医药大学学报,2023,37(05):55-60.
WU Na,LU Lei,YE Qing,et al.Multicenter observational study of Wuling Capsule in treatment of Parkinson's disease with sleep disorder[J].Academic Journal of Shanghai University of Traditional Chinese Medicine,2023,37(05):55-60.
吴娜,陆磊,叶青等.乌灵胶囊治疗帕金森病伴睡眠障碍的多中心观察性研究[J].上海中医药大学学报,2023,37(05):55-60. DOI: 10.16306/j.1008-861x.2023.05.007.
WU Na,LU Lei,YE Qing,et al.Multicenter observational study of Wuling Capsule in treatment of Parkinson's disease with sleep disorder[J].Academic Journal of Shanghai University of Traditional Chinese Medicine,2023,37(05):55-60. DOI: 10.16306/j.1008-861x.2023.05.007.
目的,2,观察乌灵胶囊治疗帕金森病(PD)伴睡眠障碍的临床疗效。,方法,2,纳入168例PD伴睡眠障碍患者,在标准诊断及治疗基础上,加服乌灵胶囊治疗,疗程为4周。分别于治疗前及治疗4周后评估所有纳入患者的PD睡眠量表2(PDSS2)及PD患者生活质量问卷简化版(PDQ-8)评分,以评价临床疗效;同时,比较不同性别、是否服用安眠药、伴有不同数量慢性疾病患者的疗效差异。,结果,2,①治疗4周后,患者的PDSS2、PDQ-8评分均下降(,P,<,0.05);通过对睡眠障碍分类评估发现,乌灵胶囊对睡眠相关症状改善更显著(Cohen's ,d,值,>,0.8)。②服用乌灵胶囊后,服用安眠药患者的PDSS2夜间PD相关症状、睡眠相关症状评分及总分下降更显著;伴有≥3种慢性疾病患者的PDSS2夜间运动相关症状评分下降最显著,伴有2种慢性疾病患者的PDSS2总分下降最显著。,结论,2,乌灵胶囊对以睡眠相关症状为主的PD伴睡眠障碍患者有改善效应,同时,乌灵胶囊联合安眠药治疗比单用乌灵胶囊治疗疗效更显著。
Objective: To observe the clinical efficacy of Wuling Capsule in the treatment of Parkinson's disease (PD) with sleep disorder.,Methods,2,A total of 168 patients with PD complicated with sleep disorder were collected. On the basis of standard diagnosis and treatment, Wuling Capsule was added for a course of 4 weeks. Before treatment and after 4 weeks of treatment, the scores of PD sleep scale-2 (PDSS2) and the short-form 8-item PD questionnaire (PDQ-8) of all patients were assessed in order to evaluate the clinical efficacy. Meanwhile, the efficacy differences of patients with different sexes, whether taking hypnotic or not, and with different number of chronic diseases were compared.,Results,2,①After 4 weeks of treatment, the scores of PDSS2 and PDQ-8 were decreased (,P,<,0.05). Through the classification and evaluation of sleep disorders, the study found that Wuling Capsule improved sleep related symptoms more significantly (Cohen's ,d,>,0.8). ②After taking Wuling Capsule, the scores of PD related symptoms at night and sleep related symptoms and the total score of PDSS2 were decreased more significantly among patients who took hypnotic; the score of motor related symptoms at night of PDSS2 were decreased the most significantly among patients with ≥3 chronic diseases, and the total score of PDSS2 were decreased the most significantly among patients with 2 chronic diseases.,Conclusion,2,Wuling Capsule has improvement effect on the sleep related symptoms in patients of PD with sleep disorder, meanwhile Wuling Capsule combined with hypnotic has more significant effect than Wuling Capsule alone.
帕金森病睡眠障碍乌灵胶囊多中心观察性研究
Parkinson's diseasesleep disorderWuling Capsulemulticenterobservational study
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