不同组方的四黄散外用治疗小鼠输液性静脉炎的作用比较

肖秋元; 雷雨禾; 陈蕾; 朱昌丰; 王文婷

doi:10.16306/j.1008-861x.2023.01.010

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不同组方的四黄散外用治疗小鼠输液性静脉炎的作用比较

实验研究 | 更新时间：2023-02-14

- 不同组方的四黄散外用治疗小鼠输液性静脉炎的作用比较
- Comparison of effects of external application of Sihuang Powder with different formulas in treatment of infusion phlebitis in mice
- 上海中医药大学学报 2023年37卷第1期页码：70-74
- 作者机构：
  
  1.广州中医药大学深圳医院（福田）药学部（广东　深圳　518000）
  2.山西省汾阳医院健康体检中心（山西　吕梁　032200）
- 作者简介：
  
  肖秋元，女，硕士，主管中药师，主要从事中药临床药学和中药药理研究
  王文婷，副主任护师；E-mail：fyyywwt@163.com
- 基金信息：
  
  深圳市福田区卫生公益性科研基金项目(FTWS2020066)
- DOI：10.16306/j.1008-861x.2023.01.010
  中图分类号：
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肖秋元,雷雨禾,陈蕾等.不同组方的四黄散外用治疗小鼠输液性静脉炎的作用比较[J].上海中医药大学学报,2023,37(01):70-74.

XIAO Qiuyuan,LEI Yuhe,CHEN Lei,et al.Comparison of effects of external application of Sihuang Powder with different formulas in treatment of infusion phlebitis in mice[J].Academic Journal of Shanghai University of Traditional Chinese Medicine,2023,37(01):70-74.
肖秋元,雷雨禾,陈蕾等.不同组方的四黄散外用治疗小鼠输液性静脉炎的作用比较[J].上海中医药大学学报,2023,37(01):70-74. DOI： 10.16306/j.1008-861x.2023.01.010.

XIAO Qiuyuan,LEI Yuhe,CHEN Lei,et al.Comparison of effects of external application of Sihuang Powder with different formulas in treatment of infusion phlebitis in mice[J].Academic Journal of Shanghai University of Traditional Chinese Medicine,2023,37(01):70-74. DOI： 10.16306/j.1008-861x.2023.01.010.

摘要

目的,2,观察不同组方四黄散软膏外用对氟尿嘧啶相关性静脉炎小鼠的作用效果，优选出治疗静脉炎的最佳组方。,方法,2,制备不同组方的四黄散A、B、C、D软膏，将49只小鼠随机分成7组：空白组、模型组、阳性对照组及四黄散A、B、C、D软膏组。除空白组外，其余6组均连续3 d尾静脉注射氟尿嘧啶建立静脉炎模型，四黄散各软膏组分别外涂四黄散A、B、C、D软膏，阳性对照组外涂多磺酸粘多糖乳膏，空白组和模型组外涂空白赋形剂，观察各组小鼠静脉炎炎症程度、鼠尾肿胀度、静脉血炎性因子水平和鼠尾病理形态学变化。,结果,2,与空白组比较，模型组静脉炎分级、鼠尾肿胀度、静脉血炎性因子水平均升高（,P,<,0.05，,P,<,0.001），提示造模成功；四黄散各软膏组外涂5 d后，与治疗前比较，静脉炎分级、鼠尾肿胀度均降低（,P,<,0.05，,P,<,0.001），与模型组比较， CRP、IL-6和TNF-α水平均降低（,P,<,0.001）；与阳性对照组比较，四黄散C组治疗后，CRP和IL-6的水平降低（,P,<,0.05，,P,<,0.001）；病理切片形态学观察显示四黄散各软膏组均能降低静脉炎炎症程度。,结论,2,不同组方四黄散外用均能有效减轻氟尿嘧啶静脉注射导致的小鼠静脉炎，其中以四黄散组方C效果最优。

Abstract

Objective： To observe the therapeutic effects of different formulas of Sihuang Powder Ointment topically applied on mice with fluorouracil-associated phlebitis， and to select the optimal formula for the treatment of phlebitis.,Methods,2,Different formulas of Sihuang Powder Ointment A， B， C， D were prepared. Forty-nine mice were randomly divided into 7 groups： blank group， model group， positive control group and Sihuang Powder Ointment A， B， C， D groups. Except for the blank group， the mice in other 6 groups were injected with fluorouracil through tail vein for 3 consecutive days to establish phlebitis model. The Sihuang Powder Ointment groups were treated topically with Sihuang Powder Ointment A， B， C， and D correspondingly， the positive control group was treated topically with mucopolysaccharide polysulfate cream， and the blank and model groups were treated topically with blank excipient. The degree of phlebitis， the swelling degree of rat tail， the levels of inflammatory factors in venous blood， and the rat tail pathomorphological changes were observed in each group.,Results,2,Compared with the blank group， the grade of phlebitis， swelling degree of tail， and levels of inflammatory factors in venous blood in the model group were increased （,P,<,0.05， ,P,<,0.001）， indicating successful molding. After external treatment with Sihuang Powder Ointment A， B， C， D for 5 d correspondingly， the grade of phlebitis and swelling degree of tail in each Sihuang Powder Ointment group were decreased compared with those before treatment （,P,<,0.05， ,P,<,0.001）， the levels of CRP， IL-6 and TNF-α were decreased compared with the model group （,P,<,0.001）. The levels of CRP and IL-6 were decreased in Sihuang Powder C group after treatment compared with the positive control group （,P,<,0.05， ,P,<,0.001）. The degree of phlebitis inflammation in each Sihuang Powder Ointment group was reduced based on morphological observation of pathological sections.,Conclusion,2,External application of different formulas of Sihuang Powder can effectively reduce the phlebitis in mice induced by intravenous injection of fluorouracil， among which Sihuang Powder C has the best effect.

关键词

四黄散静脉炎氟尿嘧啶

Keywords

Sihuang Powderphlebitisfluorouracil

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