中药活性成分百秋李醇在疾病防治中的实验研究进展

畅立圣; 陈红宇; 张莹瑄; 陈文莉; 杨柳

doi:10.16306/j.1008-861x.2022.S1.055

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中药活性成分百秋李醇在疾病防治中的实验研究进展

综　　述 | 更新时间：2022-08-29

- 中药活性成分百秋李醇在疾病防治中的实验研究进展
- Progress in experimental research of traditional Chinese medicine active ingredient patchouli alcohol on prevention and treatment of diseases
- 上海中医药大学学报 2022年36卷第S1期页码：272-276
- 作者机构：
  
  1.上海中医药大学附属曙光医院宝山分院肿瘤一科（上海　201999）
- 作者简介：
  
  畅立圣，男，硕士，主治医师，主要从事中西医结合肿瘤防治临床研究
  杨柳，副主任医师；E-mail：bsyykyc@shutcm.edu.cn
- 基金信息：
  
  国家自然科学基金资助项目(81904013);上海市自然科学基金资助项目(19ZR1438000);上海市科委医学创新研究专项项目(21Y11922200);上海市科委中医引导类项目(19401933100);上海中医药大学附属曙光医院宝山分院国家自然科学培育项目(GZRPYJJ-201801)
- DOI：10.16306/j.1008-861x.2022.S1.055
  中图分类号：
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畅立圣,陈红宇,张莹瑄等.中药活性成分百秋李醇在疾病防治中的实验研究进展[J].上海中医药大学学报,2022,36(S1):272-276.

CHANG Lisheng,CHEN Hongyu,ZHANG Yingxuan,et al.Progress in experimental research of traditional Chinese medicine active ingredient patchouli alcohol on prevention and treatment of diseases[J].Academic Journal of Shanghai University of Traditional Chinese Medicine,2022,36(S1):272-276.
畅立圣,陈红宇,张莹瑄等.中药活性成分百秋李醇在疾病防治中的实验研究进展[J].上海中医药大学学报,2022,36(S1):272-276. DOI： 10.16306/j.1008-861x.2022.S1.055.

CHANG Lisheng,CHEN Hongyu,ZHANG Yingxuan,et al.Progress in experimental research of traditional Chinese medicine active ingredient patchouli alcohol on prevention and treatment of diseases[J].Academic Journal of Shanghai University of Traditional Chinese Medicine,2022,36(S1):272-276. DOI： 10.16306/j.1008-861x.2022.S1.055.

摘要

百秋李醇是传统中草药广藿香的重要药效成分。近年百秋李醇已经报道了多种有应用前景的药用活性，包括抗流感病毒、抗炎、调节肠道菌群治疗慢性肠病、抗抑郁、镇痛、改善急性脑损伤、抗肿瘤、抗代谢相关疾病等。本综述将对百秋李醇在疾病中的实验研究进展总结，并试就当前研究中存在的问题进行分析，为进一步开展后续研究提供一定参考。

Abstract

Patchouli alcohol is an important active ingredient of traditional Chinese medicine Pogostemonis Herba. In recent years， a variety of promising medicinal activities of patchouli alcohol have been reported， including influenza virus treatment， anti-inflammatory， regulating intestinal flora treatment of chronic intestinal diseases， anti-depression， analgesia， improving acute brain injury， antitumor， resisting metabolic related diseases， etc. This review will summarize the progress of the experimental research on patchouli alcohol in diseases， and try to analyze the existing problems in the current research， to provide a reference for further research.

关键词

百秋李醇广藿香活性成分实验研究

Keywords

patchouli alcoholPogostemonis Herbaactive ingredientsexperimental research

references

WU Z N，ZENG H R，ZHANG L L，et al. Patchouli alcohol：a natural sesquiterpene against both inflammation and intestinal barrier damage of ulcerative colitis［J］. Inflammation，2020，43（4）：1423-1435.

徐雯，吴艳清，丁浩然，等.广藿香的药理作用及机制研究进展［J］.上海中医药杂志，2017， 51（10）： 103-106.

VAN BEEK T A，JOULAIN D. The essential oil of patchouli，Pogostemon Cablin：a review［J］. Flavour Fragr J，2018， 33（1）：6-51.

SWAMY M K，SINNIAH U R. A Comprehensive Review on the Phytochemical Constituents and Pharmacological Activities of Pogostemoncablin Benth.：An Aromatic Medicinal Plant of Industrial Importance［J］. Molecules， 2015， 20（5）： 8521-8547.

LEE H S，LEE J，SMOLENSKY D，et al. Potential benefits of patchouli alcohol in prevention of human diseases： A mechanistic review［J］. Int Immunopharmacol， 2020， 89（Pt A）： 107056.

WU H X，LI B L， WANG X，et al. Inhibitory effect and possible mechanism of action of patchouli alcohol against influenza A （H2N2） virus［J］. Molecules， 2011， 16（8）： 6489-6501.

YU Y J，ZHANG Y，WANG S Y，et al. Inhibition effects of patchouli alcohol against influenza a virus through targeting cellular PI3K/Akt and ERK/MAPK signaling pathways［J］. Virol J，2019， 16（1）： 163.

LI Y C，PENG S Z，CHEN H M，et al. Oral administration of patchouli alcohol isolated from Pogostemonis Herba augments protection against influenza viral infection in mice［J］. Int Immunopharmacol，2012， 12（1）： 294-301.

WU X L，JU D H，CHEN J，et al. Immunologic mechanism of Patchouli alcohol anti-H1N1 influenza virus may through regulation of the RLH signal pathway in vitro［J］. Curr Microbiol，2013， 67（4）： 431-436.

XIAN Y F，LI Y C，IP S P，et al. Anti-inflammatory effect of patchouli alcohol isolated from Pogostemonis Herba in LPS-stimulated RAW264.7 macrophages［J］. Exp Ther Med， 2011， 2（3）： 545-550.

JEONG J B，SHIN Y K，LEE S H. Anti-inflammatory activity of patchouli alcohol in RAW264.7 and HT-29 cells［J］. Food Chem Toxicol， 2013， 55： 229-233.

LIAO J B，WU D W，PENG S Z，et al.Immunomodulatory potential of patchouli alcohol isolated from Pogostemoncablin （Blanco） Benth （Lamiaceae） in mice［J］. Trop J Pharm Res， 2013， 12（4）： 559-565.

YU J L，ZHANG X S，XUE X，et al.Patchouli alcohol protects against lipopolysaccharide-induced acute lung injury in mice［J］. J Surg Res， 2015， 194（2）： 537-543.

ZHANG G，LIU M，SONG M，et al.Patchouli alcohol activates PXR and suppresses the NF-κB-mediated intestinal inflammatory［J］. J Ethnopharmacol， 2020， 248： 112302.

ZHENG Y F，XIE J H，XU Y F，et al.Gastroprotective effect and mechanism of patchouli alcohol against ethanol， indomethacin and stress-induced ulcer in rats［J］.Chem Biol Interact， 2014， 222： 27-36.

XIE J，LIN Z，XIAN Y，et al. （-）-Patchouli alcohol protects against Helicobacter pylori urease-induced apoptosis， oxidative stress and inflammatory response in human gastric epithelial cells［J］. Int Immunopharmacol， 2016， 35： 43-52.

LIAN D W， XU Y F， REN W K，et al.Unraveling the Novel Protective Effect of Patchouli Alcohol Against Helicobacter pylori-Induced Gastritis： Insights Into the Molecular Mechanism in vitro and in vivo［J］. Front Pharmacol，2018， 9： 1347.

刘培文，陆敏强，何占坤，等.百秋李醇对幽门螺杆菌致小鼠胃炎的保护作用［J］.中国医院药学杂志，2022， 42（1）： 19-23.

KAPLAN G G， NG S C. Understanding and Preventing the Global Increase of Inflammatory Bowel Disease［J］. Gastroenterology，2017， 152（2）： 313-321.

LIU X， JIANG L， LIU F， et al.Effect of patchouli alcohol on the regulation of heat shock-induced oxidative stress in IEC-6 cells［J］. Int J Hyperthermia，2016， 32（5）： 474-482.

WU J，GAN Y，LI M，et al.Patchouli alcohol attenuates 5-fluorouracil-induced intestinal mucositis via TLR2/ MyD88/NF-kB pathway and regulation of microbiota［J］. Biomed Pharmacother， 2020， 124： 109883.

LEONG W，HUANG G，KHAN I，et al.Patchouli Essential Oil and Its Derived Compounds Revealed Prebiotic-Like Effects in C57BL/6J Mice［J］. Front Pharmacol，2019， 10： 1229.

LIBUSOVA L，STEMMLER M P，HIERHOLZER A，et al.N-cadherin can structurally substitute for E-cadherin during intestinal development but leads to polyp formation［J］.Development，2010， 137（14）： 2297-2305.

CHEN M，ZHANG J，LAI Y，et al.Analysis of Pogostemon cablin from pharmaceutical research to market performances［J］. Expert Opin Investig Drugs， 2013， 22（2）： 245-257.

ZHUO J，CHEN B，SUN C，et al.Patchouli alcohol protects against chronic unpredictable mild stress-induced depressant-like behavior through inhibiting excessive autophagy via activation of mTOR signaling pathway［J］. Biomed Pharmacother， 2020， 127： 110115.

SAH S P，MATHELA C S，CHOPRA K. Antidepressant effect of Valeriana wallichii patchouli alcohol chemotype in mice： Behavioural and biochemical evidence［J］. J Ethnopharmacol，2011， 135（1）： 197-200.

YU X，WANG X P，YAN X J，et al.Anti-nociceptive effect of patchouli alcohol： Involving attenuation of cyclooxygenase 2 and modulation of mu-opioid receptor［J］. Chin J Integr Med， 2019， 25（6）： 454-461.

PRADO W A. Involvement of calcium in pain and antinociception［J］. Braz J Med Biol Res， 2001， 34（4）： 449-561.

WEI L L，CHEN Y，YU Q Y，et al.Patchouli alcohol protects against ischemia/reperfusion-induced brain injury via inhibiting neuroinflammation in normal and obese mice［J］. Brain Res，2018， 1682： 61-70.

LU X，YANG L，LU C，et al.Molecular Role of EGFR-MAPK Pathway in Patchouli Alcohol-Induced Apoptosis and Cell Cycle Arrest on A549 Cells In Vitro and In Vivo［J］. Biomed Res Int， 2016， 2016： 4567580.

JEONG J B，CHOI J，LOU Z，et al.Patchouli alcohol， an essential oil of Pogostemon cablin， exhibits anti-tumorigenic activity in human colorectal cancer cells［J］. Int Immunopharmacol， 2013， 16（2）： 184-190.

YANG L，CHEN H，LI R，et al.Mufangji Decoction and Its Active Ingredient Patchouli Alcohol Inhibit Tumor Growth through Regulating Akt/mTOR-Mediated Autophagy in Nonsmall-Cell Lung Cancer［J］. Evid Based Complement Alternat Med， 2021， 2021： 2373865.

SONG Y，CHANG L，WANG X，et al. Regulatory Mechanism and Experimental Verification of Patchouli Alcohol on Gastric Cancer Cell Based on Network Pharmacology［J］.Front Oncol， 2021， 11： 711984.

WANG H T，WANG Z Z，WANG Z C，et al. Patchouli alcohol attenuates experimental atherosclerosis via inhibiting macrophage infiltration and its inflammatory responses［J］. Biomed Pharmacother， 2016， 83： 930-935.

LEE J，KONG B，LEE S H. Patchouli Alcohol， a Compound from Pogostemon cablin， Inhibits Obesity［J］. J Med Food， 2020， 23（3）： 326-334.

WU X，XU N，LI M，et al.Protective Effect of Patchouli Alcohol Against High-Fat Diet Induced Hepatic Steatosis by Alleviating Endoplasmic Reticulum Stress and Regulating VLDL Metabolism in Rats［J］. Front Pharmacol， 2019， 10： 1134.

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