Objective： To explore the potential active components and mechanism of ,Fructus Arctii, on diabetic nephropathy.,Methods,2,The active components， targets and two-dimensional structure diagram of ,Fructus Arctii, were collected through the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform （TCMSP）. The related targets of diabetic nephropathy were obtained from TTD database， Drugbank database， GeneCards database and OMIM database， the repeated targets were eliminated， and then the Uniprot ID of each target was determined in combination with Uniprot database. On the basis of data from String database， the topological value of PPI network is calculated by the Network Analyzer and cytoHubba plugin of Cytoscape 3.7.0 software， and the topological network diagram for important targets is constructed. The network diagram of “active ingredient-target-pathway” is drawn. The core targets were imported into Metascape database for GO biological process enrichment analysis and KEGG analysis. The crystal structure of key target protein was downloaded from RSCB database， docked by AutoDock， and visualized by Pymol software.,Results,2,Fructus Arctii, has 8 active components and 80 main targets， and 34 targets were obtained after intersection with diabetic nephropathy targets. The core targets include transcription factor AP-1 （,JUN,）， tumor necrosis factor （,TNF,）， serine-threonine kinase （,AKT1,）， catenin protein beta 1 （,CT,-,NNB1,）， vascular endothelial growth factor A （,VEGFA,）， mitogen-activated protein kinase （,MAPK8,）， vascular cell adhesion molecule-1 （,VCAM1,）， nitric oxide synthase 2 （,NOS2,）， intercellular adhesion molecule-1 （,ICAM1,） and E-selectin （,SELE,）. Thirty GO items were obtained by GO enrichment analysis， and the top 10 main pathways were selected by KEGG pathway enrichment including fluid shear stress and atherosclerosis， advanced glycosylation end products （AGEs）-receptor of AGEs （RAGE） signaling pathway in diabetic complications， cancer pathway， tumor necrosis factor signaling pathway， Kaposi’s sarcoma-associated herpes virus infection， non-alcoholic fatty liver disease， Interleukin-17 signaling pathway， C-type lectin receptor signaling pathway， toxoplasmosis， proteoglycan in cancer， etc. It is speculated that AGE-RAGE signaling pathway in diabetic complications is the most closely related to diabetic nephropathy. The results of molecular docking showed that the active components of, Fructus Arctii, docked with multiple targets， and the binding energy between β-sitosterol and AKT1， kaempferol and TNF was low.,Conclusion,2,Fructus Arctii, may treat diabetic nephropathy through multiple components， multiple targets and multiple pathways.