1.上海市浦东新区中医医院心内科(上海 201299)
贺卫,男,硕士,主治医师,主要从事中西医结合治疗心血管疾病的临床研究
秦莹,主任医师;E-mail: qinying73@sina. com
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贺卫,朱慧英,丁嘉怡等.中药联合针刺治疗气虚血瘀证慢性心力衰竭(心功能分级Ⅱ级)的临床疗效[J].上海中医药大学学报,2022,36(S1):76-79.
HE Wei,ZHU Huiying,DING Jiayi,et al.Clinical efficacy of traditional Chinese medicine combined with acupuncture on chronic heart failure (cardiac function grade Ⅱ) with Qi deficiency and blood stasis syndrome[J].Academic Journal of Shanghai University of Traditional Chinese Medicine,2022,36(S1):76-79.
贺卫,朱慧英,丁嘉怡等.中药联合针刺治疗气虚血瘀证慢性心力衰竭(心功能分级Ⅱ级)的临床疗效[J].上海中医药大学学报,2022,36(S1):76-79. DOI: 10.16306/j.1008-861x.2022.S1.019.
HE Wei,ZHU Huiying,DING Jiayi,et al.Clinical efficacy of traditional Chinese medicine combined with acupuncture on chronic heart failure (cardiac function grade Ⅱ) with Qi deficiency and blood stasis syndrome[J].Academic Journal of Shanghai University of Traditional Chinese Medicine,2022,36(S1):76-79. DOI: 10.16306/j.1008-861x.2022.S1.019.
目的,2,观察中药联合针刺结合西医常规疗法治疗气虚血瘀证慢性心力衰竭(心功能Ⅱ级)的临床疗效。,方法,2,纳入72 例慢性心力衰竭(心功能Ⅱ级)患者,随机分为治疗组与对照组,每组各36例。对照组患者予西医基础治疗,治疗组患者在对照组基础上加用中药内服联合针刺治疗,两组疗程均为4周。评价两组的临床疗效;治疗前后,计算两组患者的左室射血分数(LVEF),检测并比较两组患者的血清N末端脑钠肽前体(NT-proBNP)、转化生长因子- β,1,(TGF- β,1,)、结缔组织生长因子(CTGF)、Ⅰ型前胶原(PCⅠ)、Ⅲ型前胶原(PC Ⅲ)水平。,结果,2,试验期间,治疗组5例患者剔除或脱落,对照组6例患者剔除或脱落,最终纳入统计分析者治疗组31 例、对照组 30 例。①治疗后,治疗组、对照组的临床总有效率分别为74.19%、63.33%,治疗组的疗效明显优于对照组(,P,<,0.05)。②治疗后,两组患者的LVEF水平均明显升高(,P,<,0.05),血清NT-proBNP、TGF-β,1,、CTGF、PCⅠ、PC Ⅲ水平均明显降低(,P,<,0.05),且治疗组患者的LVEF水平高于对照组(,P,<,0.05)。,结论,2,与单纯西医常规疗法相比,中药联合针刺结合西医常规疗法治疗气虚血瘀证慢性心力衰竭(心功能Ⅱ级)患者,可有效改善患者的心衰指标,提高临床疗效。
Objective: To observe the clinical efficacy of traditional Chinese medicine combined with acupuncture and conventional western medicine treatment in the treatment of chronic heart failure (cardiac function grade Ⅱ) with Qi deficiency and blood stasis syndrome.,Methods,2,Seventy-two patients with chronic heart failure (cardiac function grade Ⅱ) were randomly divided into treatment group and control group, 36 cases in each group. The control group was treated with basic western medicine. On the basis of the control group, the treatment group was treated with traditional Chinese medicine combined with acupuncture. The treatment course of both groups was 4 weeks. The clinical efficacy was observed. Before and after treatment, the left ventricular ejection fraction (LVEF) was calculated, and the serum levels of N-terminal pro-brain natriuretic peptide (NT- ProBNP), transforming growth factor-β,1, (TGF-β,1,), connective tissue growth factor (CTGF), procollagen Ⅰ (PC Ⅰ) and procollagen Ⅲ (PC Ⅲ) in patients of both groups were detected and compared.,Results,2,During the experiment, 5 patients in the treatment group and 6 patients in the control group were excluded or dropped out. Finally, 31 patients in the treatment group and 30 patients in the control group were included in the statistical analysis. ①After treatment, The total clinical effective rate of the treatment group and the control group was 74.19% and 63.33%, respectively. And the clinical curative effect of the treatment group was significantly better than that in the control group (,P<,0.05). ②After the treatment, the LVEF level in both groups was significantly increased (,P,<,0.05). The serum levels of NT-ProBNP, TGF-β,1,, CTGF, PCⅠ, PC Ⅲ were significantly decreased, and the level of LVEF in the treatment group was higher than that in the control group (,P<,0.05).,Conclusion,2,Compared with the conventional treatment of western medicine, traditional Chinese medicine combined with acupuncture and conventional western medicine treatment can effectively improve the index of heart failure in patients suffering from chronic heart failure (cardiac function grade Ⅱ) with Qi deficiency and blood stasis syndrome and improve the clinical efficacy.
慢性心力衰竭气虚血瘀证针刺中药
chronic heart failureQi deficiency and blood stasis syndromeacupuncturetraditional Chinese medicine
中华医学会心血管病学分会,中华心血管病杂志编辑委员会. 中国心力衰竭诊断和治疗指南(2014) [J]. 中华心血管病杂志,2014, 42(2): 98-122.
张健,张宇辉. 多中心、前瞻性中国心力衰竭注册登记研究——病因、临床特点和治疗情况初步分析[J]. 中国循环杂志,2015, 30(5): 413-416.
曾学寨,刘德平. 2016年欧洲心脏病协会心力衰竭指南解读[J]. 中国心血管杂志,2016, 21(5): 355-358.
许顶立,白煜佳. 2017ACC/AHA/HFSA心力衰竭管理指南更新解读[J]. 中国全科医学,2017, 20(10): 3579-3583.
中国中西医结合学会心血管疾病专业委员会,中国医师协会中西医结合医师分会心血管病学专家委员会. 慢性心力衰竭中西医结合诊疗专家共识(2016)[J]. 中西医结合心脑血管病杂志,2016, 14(3): 225-232.
潘光明,邹旭. 邓铁涛“暖心胶囊”对慢性心衰患者血浆脑钠肽水平及心功能的影响[J]. 江苏中医药,2006, 27(9): 19-21.
刘建平. 临床试验样本含量的计算[J]. 中国中西医结合杂志,2003, 23(7): 536-538.
国家药品监督管理局. 中药新药临床研究指导原则(试行)[M]. 北京: 中国医药科技出版社,2002: 77-85.
冠心病中医临床研究联盟,中国中西医结合学会心血管疾病专业委员会,中华中医药学会心病分会,中国医师协会中西医结合医师分会心血管病学专家委员会. 慢性心力衰竭中医诊疗专家共识[J]. 中医杂志,2014, 55(14): 1258-1260.
KANNEL W B,HO K,THOM T. Changing epidemiological features of cardiac failure[J]. Br Heart J, 1994, 72(suppl): 3-9.
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