Objective： To observe the clinical efficacy of Ningshen Ankun Formula in the treatment of climacteric syndrome.,Methods,2,Eighty patients with climacteric syndrome were randomly divided into the control group and observation group， 40 cases in each group. The control group was treated with Kunbao Pill， and the observation group was treated with Ningshen Ankun Formula， with a course of 1 month. The clinical efficacy was observed， the changes of Kuppenrman score， menopausal quality of life （MENQOL） scale， sex hormone levels and related laboratory indexes were compared， and the safety was evaluated.,Results,2,①The clinical efficacy of the observation group was better than that of the control group （,P,<,0.05）. ②The improvement of Kuppenrman score， MENQOL score， sex hormones and related laboratory indexes in the observation group were better than those in the control group （,P,<,0.05）. ③There were no significant adverse reaction in both groups.,Conclusion,2,Compared with Kunbao Pill， Ningshen Ankun Formula can better improve the clinical symptoms of patients with climacteric syndrome， regulate the levels of luteinizing hormone， estradiol and follicle stimulating hormone， and has good safety.