Objective： To evaluate the clinical efficacy of acupoint injection of astragalus injection combined with seretide on chronic obstructive pulmonary disease （COPD） at stable stage.,Methods,2,Ninety-five patients with stable COPD were enrolled in a randomized double-blind controlled study， and randomly divided into the treatment group （,n,=48） and the control group （,n,=47）. The patients in the treatment group were given acupoint injection of astragalus injection combined with seretide， and the patients in the control group were given normal saline injection combined with seretide for 3 months. The clinical symptoms and the occurrence of adverse reactions during treatment were recorded weekly with COPD clinical symptom grading quantification table. EpiData3.0 software was used for data management， and SPSS 26.0 statistical software was used for data analysis.,Results,2,There was statistically significant difference between the two groups in the clinical efficacy of patients with stable COPD （,P,<,0.05）. And there was a linear correlation between the clinical efficacy and treatment time （,P,<,0.05）. Group was the main factor affecting the clinical efficacy evaluation of the two groups， and the clinical efficacy of the treatment group was better than that of the control group.,Conclusion,2,The clinical efficacy of astragalus injection combined with seretide in the treatment of stable COPD is better than that of seretide group， and the clinical efficacy increases with the extension of treatment time. This treatment method is safe and effective. In clinic， patients can benefit more by appropriately prolonging the treatment course.