Objective： To summarize and analyze the literatures of randomized controlled trials of acupuncture and moxibustion in the treatment of infertility， and to summarize the laws of acupoints selection， treatment methods， clinical efficacy and effective indexes of acupuncture and moxibustion in the treatment of infertility so as to provide scientific evidence for the advantages of acupuncture and moxibustion in the treatment.,Methods,2,The literatures on acupuncture and moxibustion treatment of infertility from January 1， 2015 to April 30， 2022 in TCM Acupuncture Information Database， China national knowledge infrastructure （CNKI）， Wanfang academic journal full-text database （Wanfang） and Chongqing VIP database （CQVIP） databases were retrieved by computer， and the acupoints and treatment methods in the literatures met the inclusion criteria were analyzed and summarized. The total effective rate， pregnancy rate， ovulation rate， endometrial thickness， and serum sex hormone levels of infertility of different etiologies and different treatment methods were compared.,Results,2,A total of 407 literatures were included， most of which were ovulatory dysfunction infertility. Acupuncture and moxibustion treatment of infertility involved 129 acupoints， with high-frequency acupoints being Guanyuan， Sanyinjiao， Zigong， Zusanli， Zhongji， Qihai， Shenshu and Taichong. Cluster analysis showed that the effective clustering of high-frequency acupoints are Xuehai-Taichong-Shenshu， Qihai-Zhongji-Zusanli-Zigong and Sanyinjiao-Guanyuan. The frequency of acupoint distribution was highest on Ren Channel and abdominal acupoints. Acupuncture and moxibustion combined with traditional Chinese medicine or western medicine were often used for treatment. After acupuncture and moxibustion treatment， the pregnancy rate and ovulation rate of infertility of different etiologies were different. For patients with ovulatory dysfunction infertility， the total effective rate， pregnancy rate and ovulation rate of acupuncture + western medicine group and acupuncture + traditional Chinese medicine group were higher than those of acupuncture group， western medicine group and traditional Chinese medicine group. The increase of endometrial thickness of acupuncture + western medicine group was higher than that of acupuncture group and acupuncture + traditional Chinese medicine group， and different treatments could all regulate the level of sex hormones.,Conclusions,2,Acupuncture and moxibustion treatment of infertility are mainly based on local acupoints， and to determine acupoints per meridians dominated the disease， Guanyuan and Sanyinjiao can be treated as the main acupoints. Acupuncture and moxibustion therapy alone or combined with drugs can both effectively improve pregnancy rate and ovulation rate， increase endometrial thickness， regulate the level of sex hormones in patients. Acupuncture and moxibustion has the superior advantages in the treatment of infertility.