Objective： The fluidized bed granulation process of anti-Hashimoto’s thyroiditis Formula Granules was optimized to improve the drug loading capacity of the formulation， and then the quality evaluation of the obtained granules was carried out accordingly.,Methods,2,Taking preparation feasibility， forming rate， particle size and fluidity of granules as evaluation indexes， the initial material temperature， inlet air temperature and concentrated solution density of fluidized bed granulation were investigated by single factor experiment. HPLC method was established for content determination of calycosin-7-,O,-β-,D,-glucoside and rosmarinic acid in the granules， and the moisture， particle size and solubility of the granules were examined by ,Chinese Pharmacopoeia’s, methods.,Results,2,The optimized granulation parameters were as follows： initial material temperature （38±1）℃， air inlet temperature 70℃， concentrated liquid density was 1.24~1.26 g/cm,3, （25 ℃）. The drug loading of the obtained granules was 72%， which was about 50% higher than that before optimization. The contents of calycosin-7-,O,-β-,D,-glucoside and rosmarinic acid in the obtained preparation were 0.298 3 mg/g and 0.989 5 mg/g， respectively. Meanwhile， its moisture， particle size and solubility and other inspection items all met the requirements of ,Chinese Pharmacopoeia,.,Conclusion,2,The preparation process obtained in this study is stable and feasible， and the drug loading capacity is high. The related quality research can lay a foundation for further formulation of quality standard of the preparation.