徐长卿散剂联合布地奈德治疗激素敏感性咳嗽的临床疗效
Clinical effect of Cynanchi Paniculati Radix Et Rhizoma powder combined with budesonide in treatment of corticosteroid⁃responsive cough
- 上海中医药大学学报 2022年36卷第4期 页码：26-30
- 作者机构：
1.广西骨伤医院综合内科（广西 南宁 530012）
- 作者简介：
龙胜泽，男，硕士，主任医师，主要从事中医药防治呼吸系统疾病的临床研究
黄少东，主治医师；E-mail： 1933058547@qq.com
- 基金信息：广西中医药适宜技术开发与推广项目(GZSY21-06)
DOI：10.16306/j.1008-861x.2022.04.004
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龙胜泽,黄少东,陈艳等.徐长卿散剂联合布地奈德治疗激素敏感性咳嗽的临床疗效[J].上海中医药大学学报,2022,36(04):26-30.
LONG Shengze,HUANG Shaodong,CHEN Yan,et al.Clinical effect of Cynanchi Paniculati Radix Et Rhizoma powder combined with budesonide in treatment of corticosteroid⁃responsive cough[J].Academic Journal of Shanghai University of Traditional Chinese Medicine,2022,36(04):26-30.
龙胜泽,黄少东,陈艳等.徐长卿散剂联合布地奈德治疗激素敏感性咳嗽的临床疗效[J].上海中医药大学学报,2022,36(04):26-30. DOI： 10.16306/j.1008-861x.2022.04.004.
LONG Shengze,HUANG Shaodong,CHEN Yan,et al.Clinical effect of Cynanchi Paniculati Radix Et Rhizoma powder combined with budesonide in treatment of corticosteroid⁃responsive cough[J].Academic Journal of Shanghai University of Traditional Chinese Medicine,2022,36(04):26-30. DOI： 10.16306/j.1008-861x.2022.04.004.
摘要
目的,2,探讨徐长卿散剂联合布地奈德吸入治疗激素敏感性咳嗽（CRC）的疗效及对患者肺功能、诱导痰炎性递质、呼出气一氧化氮（FeNO）的影响。,方法,2,纳入106例CRC患者，随机分为对照组和治疗组，每组各53例。对照组患者给予布地奈德吸入气雾剂吸入治疗，治疗组患者在对照组治疗基础上给予徐长卿散剂口服，两组疗程均为8周。评价两组患者的临床疗效；比较两组患者的咳嗽症状积分；检测所有患者的肺功能指标［包括用力肺活量（FVC）、第1秒用力呼气容积（FEV,1,）、FEV,1,/FVC及呼气峰流速（PEFR）］，诱导痰中白介素（IL）-5、IL-8水平及嗜酸性粒细胞（EOS）比率，FeNO水平；评价治疗的安全性。,结果,2,①治疗后，对照组、治疗组的临床总有效率分别为71.70%、90.57%，治疗组患者的临床疗效优于对照组（,P,<,0.05）。②治疗后，两组患者的咳嗽症状积分较治疗前均降低（,P,<,0.05），且治疗组患者的积分均低于对照组（,P,<,0.05）。③治疗后，两组患者的FVC、FEV,1,、FEV,1,/FVC、PEFR水平较治疗前均升高（,P,<,0.05），且治疗组患者的FVC、FEV,1,、FEV,1,/FVC、PEFR水平高于对照组（,P,<,0.05）。④治疗后，两组患者的诱导痰中IL-5、IL-8水平和EOS比率及FeNO水平较治疗前均明显降低（,P,<,0.05），且治疗组患者的上述指标水平均低于对照组（,P,<,0.05）。⑤治疗过程中，对照组患者的不良反应发生率为24.53%，治疗组患者的不良反应发生率为7.55%，治疗组患者的不良反应发生率低于对照组（,P,<,0.05）。,结论,2,徐长卿散剂联合布地奈德吸入治疗CRC，能显著提高临床疗效，改善患者的咳嗽症状、肺功能，降低诱导痰中IL-5、IL-8水平及EOS比率，降低FeNO水平，且安全性较好。
Abstract
Objective： To explore the effects of Cynanchi Paniculati Radix Et Rhizoma powder combined with budesonide in the treatment of corticosteroid-responsive cough （CRC） and its influence on the pulmonary function， inflammatory mediators in induced sputum and fractional exhaled nitric oxide （FeNO）.,Methods,2,A total of 106 patients with CRC were included and randomly divided into the control group and the treatment group， 53 cases in each group. The patients in the control group were treated with budesonide aerosol through inhalation treatment， and the patients in the treatment group were orally treated with Cynanchi Paniculati Radix Et Rhizoma powder based on the treatment of the control group， with a course of 8 weeks. The clinical effect of the two groups was evaluated. The cough symptom score between the two groups was compared. The indexes of pulmonary function including forced vital capacity （FVC）， forced expiratory volume in one second （FEV,1,）， FEV,1,/FVC and peak expiratory flow rate （PEFR）， the levels of interleukin （IL）-5 and IL-8， and eosinophil （EOS） ratio in induced sputum， and the level of FeNO were detected. The safety of the treatment was evaluated.,Results,2,①After treatment， the total clinical effective rates of the control group and the treatment group were 71.70% and 90.57% respectively， and the clinical effect of the treatment group was better than that of the control group （,P,<,0.05）. ②After treatment， the cough symptom scores in the two groups were decreased compared with those before treatment （,P,<,0.05）， and the score of the treatment group was lower than that of the control group （,P,<,0.05）. ③After treatment， the levels of FVC， FEV,1,， FEV,1,/FVC and PEFR in the two groups were increased compared with those before treatment， and the levels of FVC， FEV,1,， FEV,1,/FVC and PEFR in the treatment group were higher than those in the control group （,P,<,0.05）. ④After treatment， the levels of IL-5， IL-8 and EOS ratio in induced sputum and FeNO in the two groups were significantly decreased compared with those before treatment （,P,<,0.05）， and the levels of above indexes in the treatment group were lower than those in the control group （,P,<,0.05）. ⑤In the course of treatment， the incidence of adverse reaction was 24.53% in the control group and 7.55% in the treatment group， and the incidence of adverse reaction in the treatment group was lower than that in the control group （,P,<,0.05）.,Conclusion,2,Cynanchi Paniculati Radix Et Rhizoma powder combined with budesonide can obviously enhance the clinical efficacy， improve the cough symptom and pulmonary function， reduce the levels of IL-5 and IL-8 and EOS ratio in induced sputum， decrease the level of FeNO， with better safety in the treatment of CRC.
关键词
激素敏感性咳嗽徐长卿散剂布地奈德肺功能诱导痰炎性递质呼出气一氧化氮
Keywords
corticosteroid-responsive coughCynanchi Paniculati Radix Et Rhizoma powderbudesonidepulmonary functioninflammatory mediators in induced sputumfractional exhaled nitric oxide
references
MORICE A H， JAKES A D， FARUQI S， et al. A worldwide survey of chronic cough： a manifestation of enhanced somatosensory response［J］. Eur Respir J， 2014， 44（5）： 1149-1155.
YI F， CHEN R， LUO W， et al. Validity of Fractional Exhaled Nitric Oxide in Diagnosis of Corticosteroid-Responsive Cough［J］. Chest， 2016， 149（4）： 1042-1051.
WATANABE H， SHIRAI T， AKAMATSU T， et al. Forced oscillatory parameters in reversibility testing as predictors for chronic cough responsive to inhaled corticosteroid/long-acting β2 agonist［J］. Ann Allergy Asthma Immunol， 2019， 122（3）： 345-346.
FUJI S， BYRNE M， NAGLER A， et al. How we can mitigate the side effects associated with systemic glucocorticoid after allogeneic hematopoietic cell transplantation［J］. Bone Marrow Transplant， 2021， 56（6）： 1248-1256.
胡晓阳， 田宇诗， 穆滨， 等. 中医药治疗慢性咳嗽的研究进展［J］. 中医药学报， 2021， 49（5）： 111-116.
中华医学会呼吸病学分会哮喘学组. 咳嗽的诊断与治疗指南（2015）［J］. 中华结核和呼吸杂志， 2016， 39（5）： 323-354.
郑筱萸. 中药新药临床研究指导原则（试行）［M］. 北京： 中国医药科技出版社， 2002： 54-58.
杨鹏， 邵发林， 王贵洁. 通过雾化诱导排痰提高新型冠状病毒核酸检测阳性二例［J］. 中华结核和呼吸杂志， 2020， 43（4）： 335-336.
GAO J， WU F， WU S， et al. Inflammatory Subtypes in Classic Asthma and Cough Variant Asthma［J］. J Inflamm Res， 2020， 13： 1167-1173.
PONTICELLI C， LOCATELLI F. Glucocorticoids in the Treatment of Glomerular Diseases： Pitfalls and Pearls［J］. Clin J Am Soc Nephrol， 2018， 13（5）： 815-822.
杨晓. 中医药治疗寒冷诱发慢性咳嗽研究进展［J］. 社区医学杂志， 2020， 18（21）： 1492-1496.
SACRE-HAZOURI J A， SACRE L. Chronic cough. Cough reflex hypersensitivity syndrome［J］. Rev Alerg Mex， 2019， 66（2）： 217-231.
ROSSIOS C， PAVLIDIS S， GIBEON D， et al. Impaired innate immune gene profiling in airway smooth muscle cells from chronic cough patients［J］. Biosci Rep， 2017， 37（6）： BSR20171090.
张雷. 咳嗽变异性哮喘（CVA）患者支气管肺泡灌洗液中炎症因子IL-5、IL-13水平的研究［J］. 中国现代医生， 2020， 58（20）： 18-22.
王岚萱， 罗海伶， 阮和球. 小五味子汤加减配合推拿手法治疗小儿慢性感染后咳嗽的临床观察［J］. 中国实验方剂学杂志， 2019， 25（16）： 85-90.
XIANG J， LIU X， ZHONG S， et al. Fructus mume Protects Against Cigarette Smoke Induced Chronic Cough Guinea Pig［J］. J Med Food， 2020， 23（2）： 191-197.
MATSUNAGA K， KUWAHIRA I， HANAOKA M， et al. An official JRS statement： The principles of fractional exhaled nitric oxide （FeNO） measurement and interpretation of the results in clinical practice［J］. Respir Investig， 2021， 59（1）： 34-52.
刘阳欣， 赵锋， 康秉涛， 等. 丹皮酚药理学研究进展［J］. 陕西中医， 2020， 41（4）： 550-552.
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