石氏熏洗方药浴对膝骨关节炎家兔股动脉血流动力学的影响及温度探索
Effect of Shi’s Fumigation and Bath Formula medicinal bath on femoral artery hemodynamics and temperature exploration in rabbits with knee osteoarthritis
- 上海中医药大学学报 2022年36卷第3期 页码：78-83
- 作者机构：
1.上海中医药大学附属曙光医院（上海 201203）
2.上海市中医药研究院骨伤科研究所（上海 201203）
- 作者简介：
张燕，女，学士，副主任医师，主要从事超声诊断临床常见疾病的研究
陈博，副研究员，硕士生导师；E-mail：cbm818@126.com
- 基金信息：国家自然科学基金资助项目(81774340;81973875);上海市科技创新行动计划医学创新研究专项(21Y11921600;20MC1920600)
DOI：10.16306/j.1008-861x.2022.03.013
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张燕,田飚,陈博等.石氏熏洗方药浴对膝骨关节炎家兔股动脉血流动力学的影响及温度探索[J].上海中医药大学学报,2022,36(03):78-83.
ZHANG Yan,TIAN Biao,CHEN Bo,et al.Effect of Shi’s Fumigation and Bath Formula medicinal bath on femoral artery hemodynamics and temperature exploration in rabbits with knee osteoarthritis[J].Academic Journal of Shanghai University of Traditional Chinese Medicine,2022,36(03):78-83.
张燕,田飚,陈博等.石氏熏洗方药浴对膝骨关节炎家兔股动脉血流动力学的影响及温度探索[J].上海中医药大学学报,2022,36(03):78-83. DOI： 10.16306/j.1008-861x.2022.03.013.
ZHANG Yan,TIAN Biao,CHEN Bo,et al.Effect of Shi’s Fumigation and Bath Formula medicinal bath on femoral artery hemodynamics and temperature exploration in rabbits with knee osteoarthritis[J].Academic Journal of Shanghai University of Traditional Chinese Medicine,2022,36(03):78-83. DOI： 10.16306/j.1008-861x.2022.03.013.
摘要
目的,2,研究石氏熏洗方药浴对膝骨关节炎（KOA）家兔股动脉血流动力学的影响并探索合适的治疗温度。,方法,2,①60只新西兰兔随机分为高温组、中温组、低温组、假手术组和模型组，分别采用右膝关节注射木瓜蛋白酶和左旋半胱氨酸建立KOA模型。造模4周后，对各组家兔膝关节进行水浴温度梯度干预，共治疗4周。研究不同温度下纯净水浴对KOA家兔股动脉血流动力学的影响，探索得出水浴治疗的最佳干预温度。②将50只新西兰兔随机分为石氏熏洗方药浴组、纯净水浴组、扶他林治疗组和模型组，在上述水浴最佳干预温度基础上，进一步研究不同温度下药浴对KOA家兔股动脉血流动力学的影响。,结果,2,①40 ℃时纯净水浴对股动脉内径、收缩期峰值流速、舒张期峰值流速和血管阻力指数等血流动力学指标的干预效果最优（,P,<,0.05）；②与其他温度药浴和扶他林治疗相比，40 ℃时石氏熏洗方药浴对KOA家兔血流动力学指标的改善最为明显（,P,<,0.05）。,结论,2,石氏熏洗方药浴可加快KOA家兔股动脉的血流速度，减轻血管阻力，改善局部血液循环；40 ℃为石氏熏洗方药浴治疗KOA的最佳温度。
Abstract
Objective： To study the effect of Shi’s Fumigation and Bath Formula （SFBF） medicinal bath on the hemodynamics of femoral artery in rabbits with knee osteoarthritis （KOA） and explore the appropriate treatment temperature.,Methods,2,①Sixty New Zealand rabbits were randomly divided into high-temperature group， medium-temperature group， low-temperature group， sham-operated group and model group. The KOA model was established by injecting papain and levocysteine into the right knee respectively. Four weeks after modeling， the knees of rabbits in each group were treated with pure water bath temperature gradient intervention for a total of 4 weeks to explore the appropriate treatment temperature. ②Fifty rabbits were randomly divided into SFBF medicinal bath group， pure water bath group， votalin treatment group and model group to further study the effect of traditional Chinese medicine medicinal bath on the hemodynamics of femoral artery in KOA rabbits at different temperatures based on above optimal water bath intervention temperature.,Results,2,①The intervention effect of pure water bath at 40 ℃ was optimal （,P,<,0.05） on hemodynamic indexes such as femoral artery internal diameter， systolic peak flow rate， diastolic peak flow rate and vascular resistance index. ②Compared with medicinal bath at other temperatures and votalin treatment， the improvement of hemodynamic indexes on KOA rabbits of the SFBF medicinal bath at 40 ℃ was most significant （,P,<,0.05）.,Conclusion,2,SFBF medicinal bath can accelerate the blood flow rate of the femoral artery in KOA rabbits， reduce vascular resistance and improve local blood circulation. And 40 ℃ is the optimal temperature for the treatment of KOA with the SFBF medicinal bath.
关键词
石氏熏洗方药浴膝骨关节炎血流动力学中药药浴
Keywords
traditional Chinese medicine medicinal bathknee osteoarthritishemodynamicsShi’s Fumigation and Bath Formula medicinal bath
references
YUE L，WANG J，ENOMOTO H，et al. The clinical relevance of pain severity changes： Is there any difference between Asian and Caucasian patients with osteoarthritis pain？［J］. Pain Pract， 2020， 20（2）： 129-137.
DAVIS J C，BRYAN S，BEST J R，et al. Mobility predicts change in older adults’ health-related quality of life： evidence from a Vancouver falls prevention prospective cohort study［J］. Health Qual Life Outcomes， 2015， 15（13）： 101.
PEAT G，MCCARNEY R，CROFT P. Knee pain and osteoarthritis in older adults： a review of community burden and current use of primary health care［J］. Ann Rheum Dis， 2001， 60（2）： 91-97.
DAWSON J， LINSELL L， ZONDERVAN K， et al. Epidemiology of hip and knee pain and its impact on overall health status in older adults［J］. Rheumatology （Oxford）， 2004， 43（4）： 497-504.
QUINTANA J M， ESCOBAR A， AROSTEGUI I， et al. Prevalence of symptoms of knee or hip joints in older adults from the general population［J］. Aging Clin Exp Res， 2008， 20（4）： 329-336.
TANG X， WANG S，ZHAN S， et al. The prevalence of symptomatic knee osteoarthritis in China： results from the China health and retirement longitudinal study［J］. Arthritis Rheumatol， 2016， 68（3）： 648-653.
中国中医药研究促进会骨伤科分会. 膝骨关节炎中医诊疗指南（2020年版）［J］.中医正骨，2020， 32（10）： 1-14.
LIU R，YUAN X， YU J， et al. An updated meta-analysis of the asporin gene D-repeat in knee osteoarthritis： effects of gender and ethnicity［J］. J Orthop Surg Res， 2017， 12（1）： 148.
陈世益，胡宁，贾岩波，等. 骨关节炎临床药物治疗专家共识［J］. 中国医学前沿杂志（电子版），2021， 7： 32-43.
WANG C， SCHMID C H， IVERSEN M D， et al. Comparative effectiveness of Tai Chi versus physical therapy for knee osteoarthritis： a randomized trial［J］. Ann Intern Med， 2016， 165（2）： 77-86.
曹彭凯，王晓猛，白伟侠，等. 2018年版《骨关节炎诊疗指南》解读［J］. 河北医科大学学报，2018， 39（11）： 1241-1243.
SUN J，ZHAO Y，ZHU R，et al. Acupotomy therapy for knee osteoarthritis pain： systematic review and meta-analysis［J］. Evid Based Complement Alternat Med， 2020， 2020： 2168283.
CHEN B，DUAN J， WEN S， et al. An Updated Systematic Review and Meta-analysis of Duloxetine for Knee Osteoarthritis Pain［J］. Clin J Pain. 2021， 37（11）： 852-862.
KOLASINSKI S L， NEOGI T， HOCHBERG M C， et al. 2019 American College of Rheumatology/Arthritis Foundation Guideline for the management of osteoarthritis of the hand，hip，and knee［J］. Arthritis Rheumatol， 2020， 72（2）： 220-233.
MCALINDON T E， BANNURU R R， SULLIVAN M C， et al. OARSI guidelines for the non-surgical management of knee osteoarthritis［J］. Osteoarthritis Cartilage， 2014， 22（3）： 363-388.
曹思思，史磊，王磊，等. 药浴的中医源流及应用［J］.中华中医药杂志，2020， 35（8）： 4101-4105.
CHEN B， ZHAN H， CHUNG M， et al. Chinese herbal bath therapy for the treatment of knee osteoarthritis： meta-analysis of randomized controlled trials［J］. Evid Based Complement Alternat Med， 2015， 2015： 949172.
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