Objective： To observe the syndrome characteristics of traditional Chinese medicine （TCM） in patients with amyotrophic lateral sclerosis （ALS） of different clinical types and stages.,Methods,2,A retrospective study was applied. The clinical data of 530 patients with ALS were collected， and the TCM syndrome distribution characteristics of the patients with different clinical types and stages were analyzed.,Results,2,The patients with ALS were mainly classical type and bulbar type， and the TCM syndromes of the patients mainly include deficiency of spleen and kidney， deficiency of liver and kidney， and deficiency of spleen and stomach. Among the ALS patients of classical type， bulbar type and flail leg syndrome， the proportion of the patients with syndrome of spleen and kidney deficiency was more than 50%. In early stage of ALS （stages Ⅰ and Ⅱa）， the proportion of the patients with syndromes of phlegm-dampness stagnation， qi deficiency and blood stasis， and dampness-heat in middle jiao was higher. In the middle and advanced stages of ALS （after stage Ⅱb）， the proportion of the patients with syndromes of spleen and kidney deficiency， liver and kidney deficiency， and spleen and stomach deficiency gradually increased.,Conclusion,2,Syndromes of spleen and kidney deficiency or liver and kidney deficiency run through the whole process of ALS， the disease is often accompanied by the pathological factors such as phlegm-dampness， blood stasis， dampness-heat based on deficiency syndrome in the early stage. And liver， spleen and kidney deficiency is more serious in the advanced stage. Warmingthe kidney and fortifying the spleen is the basic treatment for ALS， meanwhile， syndrome differentiation and treatment should be adopted according to the clinical types and stages of the patients.