Objective： To optimize the preparation process of Baoyuan Granules.,Methods,2,An ultra-high performance liquid chromatography-evaporative light scattering detection （UPLC-ELSD） method was established for the simultaneous determination of ginsenoside Rb,1, and astragaloside Ⅳ. Taking the transfer rates of ginsenoside Rb,1, and astragaloside Ⅳ as evaluation indexes， the effects of extraction time， extraction times and solvent volume on the extraction process of Baoyuan decoction were investigated by orthogonal test， and the effect of relative density of extractum on the drying process was observed. Based on wet granulation， taking the molding rate， angle of repose， moisture absorption rate， bulk density and solubility as evaluation indexes， the effects of excipients and wetting agents on the granulation were investigated， and the molding process of Baoyuan Granules was optimized.,Results,2,The optimum extraction process was as follows： the amount of water was 10 times， twice extraction and one hour each time. The relative density of the extractum was determined to be 1.05 to 1.15 during spray drying. The optimum molding process was wet granulation with maltodextrin as excipient and 90% ethanol as wetting agent， the dosage ratio of maltodextrin to dry paste powder was 1∶1.,Conclusion,2,The optimized preparation process of Baoyuan Granules is stable and feasible， which can provide reference for the production of Baoyuan Granules.