1.上海中医药大学交叉科学研究院(上海 201203)
2.中国科学院上海药物研究所(上海 201203)
卞娅,女,硕士,主要从事中药多糖的结构和活性机制研究
葛广波,研究员,博士生导师;E-mail:geguangbo@shutcm.edu.cn
丁侃,研究员,博士生导师;E-mail:dingkan@simm.ac.cn。
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卞娅, 葛广波, 丁侃. 中药多糖抗病毒机制研究进展[J]. 上海中医药大学学报, 2021,35(5):89-96.
BIAN Ya, GE Guangbo, DING Kan. Research advance on antiviral mechanism of herbal polysaccharides[J]. Academic Journal of Shanghai University of Traditional Chinese Medicine, 2021,35(5):89-96.
卞娅, 葛广波, 丁侃. 中药多糖抗病毒机制研究进展[J]. 上海中医药大学学报, 2021,35(5):89-96. DOI: 10.16306/j.1008-861x.2021.05.014.
BIAN Ya, GE Guangbo, DING Kan. Research advance on antiviral mechanism of herbal polysaccharides[J]. Academic Journal of Shanghai University of Traditional Chinese Medicine, 2021,35(5):89-96. DOI: 10.16306/j.1008-861x.2021.05.014.
中药多糖是中药中重要的生物活性大分子,具有抗病毒、抗菌、抗炎、抗氧化、免疫调节、调节肠道菌群等多种药理活性。近年来,研究发现,中药多糖在抗病毒及缓解病毒引发的炎症反应等方面具有较为显著的优势和独特的作用机制,因此引起了国内外学者的广泛关注。系统综述中药多糖在抗病毒及缓解病毒引发相关症状方面的机制研究进展,包括直接杀灭病毒、阻止病毒黏附和侵袭、阻止病毒复制、调节免疫、抗炎、抗氧化以及调节肠道菌群等,以期为科学诠释中药复方抗病毒的作用机制和基于中药多糖的抗病毒药物开发提供参考。
Polysaccharides are important bioactive macromolecules in Chinese medicines, with various pharmacological activities such as anti-viral, anti-bacteria, anti-inflammation, anti-oxidation, immune modulation and gut microbiota regulation.In recent years, studies have found that herbal polysaccharides showed significant advantages and unique mechanisms on anti-viral and alleviation of virus-caused inflammation, which attracted extensive attention at home and abroad.This article systematically reviews the research progress of herbal polysaccharides in anti-viral and relieving related symptoms induced by viruses, including directly killing viruses, preventing virus adhesion and invasion, preventing virus replication, regulating immunity, anti-inflammation, anti-oxidation and regulating gut microbiota, so as to provide reference for scientific interpretation of the anti-viral mechanism of Chinese medicine prescriptions and the anti-viral drugs development based on herbal polysaccharides.
中药多糖抗病毒作用机制新冠病毒综述
herbal polysaccharidesanti-viralmechanismcorona virus disease 2019 (COVID-19)review
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