Objective:,2,To observe the clinical efficacy of improved TCM respiratory guidance technology based on comprehensive pulmonary rehabilitation management in treating patients with chronic obstructive pulmonary disease(COPD) at stable stage in southern Xinjiang.,Methods:,2,A total of 100 patients with COPD at stable stage in southern Xinjiang were selected and randomly divided into the treatment group and control group, 50 cases in each group.The patients in both groups were treated with conventional western medicine, meanwhile combined with comprehensive pulmonary rehabilitation management.In comprehensive pulmonary rehabilitation management, the contracted lip-abdominal breathing training was applied for patients in the control group, and the improved TCM respiratory guidance technology training was applied for patients in the treatment group.The treatment course of both groups was 6 months, and the follow-up course was 6 months.Before and after treatment, the score of main symptoms was evaluated in both groups, and the main indexes of pulmonary ventilation function were detected, including forced expiratory volume in one second as a percentage of predicted volume(FEV,1,%), ratio of forced expiratory volume in one second(FEV,1,) to forced vital capacity(FVC) and peak expiratory flow as a percentage of predicted volume(PEF%) .The quality of life was evaluated by the score of COPD assessment test(CAT) .The motor ability and the dyspnea degree were evaluated by 6-minute walking distance(6MWD) and Borg score.The mental health was evaluated by Hamilton depression scale(HAMD) and Hamilton anxiety scale(HAMA) .Within one year of intervention, the number of acute attack hospitalization, the average hospitalization days and the total hospitalization cost were calculated and compared in both groups.,Results:,2,In the course of trial, one patient in the treatment group and one patient in the control group were excluded, finally 49 cases in the treatment group and 49 cases in the control group were included for statistical analysis.①After treatment, the score of main symptoms in both groups was significantly decreased compared with that before treatment(,P,<,0.05,P,<,0.01), and the score of the treatment group was lower than that of the control group(,P,<,0.05) .②After treatment, the levels of FEV,1,% and PEF% in the treatment group were increased compared with those before treatment(,P,<,0.05), and the levels of FEV,1,% and PEF% in the treatment group were higher than those in the control group(,P,<,0.05) .③After treatment, the CAT score in both groups was significantly decreased compared with that before treatment(,P,<,0.05,P,<,0.01), and the score of the treatment group was lower than that of the control group(,P,<,0.05) .④After treatment, the 6MWD was significantly prolonged and the Borg score was significantly decreased in the treatment group compared with those before treatment(,P,<,0.05,P,<,0.01), and the 6MWD of the treatment group was longer than that of the control group and the Borg score was lower than that of the control group(,P,<,0.05) .⑤After treatment, the scores of HAMD and HAMA in the treatment group were significantly decreased compared with those before treatment(,P,<,0.01), the score of HAMA in the control group was also decreased compared with that before treatment(,P,<,0.05), and the scores of HAMD and HAMA in the treatment group were lower than those in the control group(,P,<,0.05) .⑥During the one-year observation period, compared with the control group, the number of acute attack hospitalization was significantly reduced in the treatment group, the average hospitalization days were significantly shortened, and the total hospitalization cost was significantly decreased(,P,<,0.05,P,<,0.01) .,Conclusion:,2,The improved TCM respiratory guidance technology based on comprehensive pulmonary rehabilitation management can effectively improve the clinical symptoms of COPD patients at stable stage in southern Xinjiang, enhance the pulmonary function, improve the quality of life, meanwhile reduce the economic burden.