最新刊期
卷 38 ， 期 4 ， 2024
- 摘要：With the development of traditional Chinese medicine （TCM） in the new era， colleges and universities of TCM are facing new opportunities and challenges in the high-quality development of innovation and entrepreneurship education （hereinafter referred to as "dual innovation" education in universities of TCM）. The value connotation of high-quality development of "dual innovation" education in universities of TCM is mainly reflected in inheriting the spirit of innovation， promoting the interdisciplinary integration， and enhancing the competitiveness of TCM industry. Facing the bottlenecks and challenges of integration of "dual innovation" education and professional curriculum, teaching staff construction and instructional mode innovation, and the construction of "dual innovation" practice platform and university-enterprise integration mechanism in universities of TCM, path optimization of "dual innovation" education in universities of TCM needs to be accelerated， in order to help "dual innovation" education in universities of TCM move towards a new stage and inject new vitality and impetus for the prosperity and innovation of TCM.关键词：colleges and universities of traditional Chinese medicine;"dual innovation" education;high-quality development;value connotation;optimization path
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发布时间：2024-08-13 - 摘要：Bioeconomy has become an important means and strategic resource for re-industrialization and wealth creation in countries around the world. "Biomedicine for people's life and health" as one of the four key fields of bioeconomy， it is significant to sort out its publication trends， literature characteristics， research fields， academic influence and research hotspots for subsequent theoretical research and practical exploration. VOSviewer was used in this study to conduct visual analysis on 5 370 papers published worldwide from 2000 to 2023 in WOS core collection database， including 383 papers published by China in the field of bioeconomy， revealing the output and influence of research in the field of China's bioeconomy. The study shows that： ①The global bioeconomy research shows a continuous upward trend， which can be roughly divided into the exploration stage between 2000 and 2010 and the rapid growth stage between 2011 and 2023. ②The main publishing countries are concentrated in the developed countries of the United States and the European Union， among which Germany performs outstandingly， which is closely related to policy support， large amounts of funds and personnel investment. ③Although China's related research is slightly later than that of Europe and the United States， with the significant improvement in the strategic position of strategic emerging industries such as biomedicine， biomedical engineering， bio-agriculture， bio-manufacturing， bio-energy， bio-environmental protection， and biotechnology services in the national economic and social development， the number of papers published has increased rapidly， and the global influence has continued to increase. ④China's research is mainly focused on circular economy related to bioenergy， bioproducts， bioremediation and resource recovery， as well as circular economy related to biofuels， biomass， biochar and biodiesel. In addition， the research characteristics of biomedicine in China's bioeconomy mainly involve green synthesis， energy， environment， and biomedical applications， as well as research on medicinal plants， ethnic medicinal plants and marine algae medicinal use related to bioeconomy， and the equilibrium and non-equilibrium models of Yin-Yang and Five Elements theory for decision support in traditional Chinese medicine diagnosis. With the support of national policies， the scale of the bioeconomy industry has grown rapidly， becoming one of the core pillar industries for the development of the bioeconomy during the "14th Five-Year Plan" period（2021-2025）.关键词：bioeconomy;biomedicine;bibliometrics;knowledge graph;VOSviewer
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发布时间：2024-08-13
Scholar Forum
- 摘要：Objective： To observe the cortical specific activation response characteristics induced by limb acupuncture in stroke hemiplegic patients based on functional near-infrared spectroscopy （fNIRS）， and preliminarily explore the possible neural mechanisms of acupuncture therapy.MethodsNineteen stroke hemiplegic patients were included， who were divided into the relatively mildly impaired group （MI group， 10 cases） and relatively severely impaired group （SI group， 9 cases） according to the severity of motor dysfunction. All the patients were intervened by acupuncture on the affected side limb. In the resting state before acupuncture and during the acupuncture course， the cerebral blood oxygen parameters in the bilateral prefrontal and motor-related cortex of the patients were detected by 32-channel fNIRS system， and the interested oscillation amplitude in the fNIRS signal was calculated by time-frequency analysis method， in order to analyze the response characteristics of brain activation induced by limb acupuncture. Through intra-group and inter-group comparisons， the specific response characteristics of brain function induced by acupuncture in patients with different severity of movement disorders were focused on.ResultsThe results of intra-group analysis showed that， compared with the resting state， the activation response of Channel （Ch）26 in the motor cortex of non-affected side was significantly increased in the MI group in the acupuncture state （P<0.05）； in the acupuncture state， the activation responses of Ch1， Ch3， Ch5， Ch14 and Ch15 in the frontal lobe and motor area of affected side were significantly increased in SI group （P<0.05）， and the activation responses of Ch11 and Ch23 in the frontal lobe and motor area of non-affected side were also significantly increased （P<0.05）. The results of inter-group analysis showed that， the cortical activation responses of Ch11， Ch13， Ch24 and Ch25 induced by acupuncture in the SI group were significantly higher than those in the MI group. The results of correlation analysis showed that， the activation changes in the frontal lobe and motor area cortex induced by acupuncture in the MI group were significantly negatively correlated with the upper and lower limb motor function performance of the patients.ConclusionAcupuncture can induce a bilateral brain activation response in stroke hemiplegic patients， and the cortical activation responses in the acupuncture state of the patients with severely impaired motor function were more significant than those of the patients with mildly impaired motor function， especially in the affected hemisphere.关键词：stroke hemiplegia;acupuncture;brain function imaging;activation response;rehabilitation of traditional Chinese medicine
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发布时间：2024-08-13 - 摘要：Atrial fibrillation （AF） is a common arrhythmia disease， and its treatment focuses on rhythm control as a key goal. Acupuncture at Neiguan point （PC6） can convert AF into sinus rhythm， shorten the duration of AF， alleviate clinical symptoms， and has a positive effect on the treatment of AF in various aspects. Its mechanisms may be related to benign regulation of cardiac autonomic nervous system， bidirectional regulation of heart rate， improvement of myocardial structural remodeling and electrophysiological remodeling. This paper reviews the clinical and mechanistic researches on the treatment of AF with acupuncture at Neiguan point （PC6）， in order to provide a basis for the effectiveness of acupuncture at Neiguan point （PC6） on AF rhythm control， and to provide ideas for future related research directions.关键词：atrial fibrillation;rhythmic control;acupuncture;Neiguan point （PC6）
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发布时间：2024-08-13 - 摘要：Objective： To observe the effect of perioperative acupuncture on gastrointestinal function recovery in patients after laparoscopic cholecystectomy （LC）， in order to verify the effect of acupuncture in reducing postoperative gastrointestinal complications and improving prognosis.MethodsA total of 70 patients who underwent elective LC were randomly divided into the treatment group and control group， 35 cases in each group. The patients in the control group received enhanced recovery after surgery （ERAS） management based on the routine therapy， and the patients in the treatment group received perioperative acupuncture based on the intervention of the control group. The clinical efficacy after surgery of the two groups was evaluated. The postoperative first exhaust and defecation time， and the Visual Analogue Scale （VAS） scores of postoperative pain were compared between the two groups. At 6， 24， 48 and 72 h after surgery， the incidences of abdominal distension， nausea， and vomiting were recorded and compared. The time of drain removal， number of days of antibiotic use after surgery， number of days of postoperative hospitalization， and the total hospitalization cost were compared between the two groups， in order to evaluate the prognosis of the patients.Results①The total clinical effective rates of the two groups were 100%， and the effect of the treatment group was superior to the control group （P<0.05）. ②The postoperative first exhaust and defecation time of the treatment group was shorter than that of the control group （P<0.05）. ③At 24 h after surgery， the incidences of abdominal distension and vomiting in the treatment group were lower than those in the control group （P<0.05）. At 48 h after surgery， the incidences of nausea and vomiting in the treatment group were also lower than those in the control group （P<0.05）. ④At 6， 24， 48 and 72 h after surgery， the pain VAS score of the treatment group was lower than that of the control group （P<0.05）. ⑤The time of drain removal， number of days of antibiotic use after surgery， and number of days of postoperative hospitalization in the treatment group were shorter than those in the control group （P<0.05）， and the total hospitalization cost of the treatment group was less than that of the control group （P<0.05）.ConclusionAcupuncture in perioperative period of LC can reduce the incidences of postoperative complications， relieve the postoperative pain， and promote the recovery of gastrointestinal function after LC.关键词：laparoscopic cholecystectomy;gastrointestinal function;acupuncture;perioperative period
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发布时间：2024-08-13
Special column on acupuncture research
- 摘要：Objective： A data-driven medicinal materials recommendation method helps traditional Chinese medicine （TCM） physicians to make scientific treatment prescriptions more accurately and intelligently in real clinical practice， and can also provide a scientific basis for the development of TCM diagnosis and treatment.Methods24 127 TCM prescription records were analyzed by text mining method， and the process of generating prescriptions was simulated based on TCM theory， and the knowledge of the rich information of symptoms and medicinal materials and their interrelationships was taken into account. A TCM recommendation method based on Latent Dirichlet Allocation （LDA） topic model embedded with attribute knowledge network was proposed， and the attribute knowledge network of TCM contains rich attribute information of medicinal materials and pharmacological effects， which enhanced the topic model.ResultsThe experimental results showed that the prediction perplexity， accuracy and average Area Under Curve （AUC） of the model performed better compared with those of the baseline topic model under the optimal embedding coefficients.ConclusionThe proposed method is beneficial in improving model stability and accuracy of medicinal materials recommendation， and better undertaks tasks such as diagnosis and treatment pattern mining.关键词：traditional Chinese medicine;data mining;topic model;attribute knowledge network;herb recommendation
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发布时间：2024-08-13
Discipline Frontiers
- 摘要：Objective： To explore the clinical efficacy of Yantiao Formula （YTF） in treating elderly patients with acute cholecystitis （AC） after percutaneous transhepatic gallbladder drainage （PTGD）.MethodsA randomized， single-blind， placebo-controlled clinical study was conducted. A total of 72 elderly patients with AC undergoing PTGD were included and randomly divided into a control group and a treatment group， 36 cases in each group. All the patients were given routine intervention after PTGD. Based on above， the patients in the control group were treated with YTF placebo orally， and the patients in the treatment group were treated with YTF orally， with a treatment course of 4 weeks. Before and after treatment， the levels of inflammatory response indicators ［including white blood cell count （WBC）， neutrophil percentage （N%）， C-reactive protein （CRP）， procalcitonin （PCT）， interleukin （IL）-6］， and liver function indicators ［including total bilirubin （TBIL）， alanine aminotransferase （ALT）， aspartate aminotransferase （AST）， alkaline phosphatase （ALP）， gamma-glutamyl transpeptidase （GGT）， prothrombin time （PT）］ were detected and compared， and the total scores of traditional Chinese medicine clinical symptoms were compared between the two groups.ResultsDuring the trial， 4 patients in the control group and 6 patients in the treatment group were excluded. Finally， 32 cases in the control group and 30 cases in the treatment group were included in the statistical analysis. ①After treatment， the levels of WBC， N%， CRP， PCT and IL-6 in both groups were significantly decreased compared with those before treatment （P<0.05）， and the levels of CRP， PCT and IL-6 in the treatment group were lower than those in the control group （P<0.05）. ②After treatment， the levels of TBIL and PT in both groups were significantly decreased compared with those before treatment （P<0.05）， but there were no statistically significant differences between the two groups （P>0.05）. ③After treatment， the total scores of traditional Chinese medicine clinical symptoms in both groups were significantly decreased compared with those before treatment （P<0.01）， and the total score of the treatment group was lower than that of the control group （P<0.05）.ConclusionOral administration of YTF can further alleviate the inflammation response after gallbladder puncture and improve the clinical symptoms in elderly patients with AC after PTGD， which is worthy of clinical promotion and application.关键词：acute cholecystitis;percutaneous transhepatic gallbladder drainage;Yantiao Formula;inflammatory indicators;integrated traditional Chinese and western medicine
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发布时间：2024-08-13
Clinical Research
- 摘要：Objective： To investigate the positioning method of "Ciliao （BL32）" acupoint in mice， and provide a precise and feasible approach for Ciliao （BL32） acupoint location in mice.Methods①Healthy adult C57BL mice were taken， and the coordinate point of Ciliao （BL32） was determined by dissection. ②Adult C57BL mice were selected and randomly divided into the experimental group and control group， and the coordinate positioning method and the acupoint positioning method with "L6 spinous process" as the bony sign were respectively applied for acupiont selection. The accuracy of the two acupoint selection methods were compared. ③Adult C57BL mice were selected and the interstitial cystitis （IC） model of mouse was copied. The coordinate positioning method was applied for treatment and its functional effect was verified.ResultsThe coordinates of Ciliao （BL32） acupoint of healthy adult mice were （±1 mm， 21 mm， -5 mm）， and the accuracy of the coordinate positioning method was higher than that of the bone sign positioning method. Meanwhile the electroacupuncture treatment applying the coordinate positioning method could improve the related symptoms of IC mice.ConclusionThe accuracy of the coordinate positioning method is higher than that of the bone sign positioning method， and has the function of Ciliao （BL32） acupoint.关键词：Ciliao （BL32） acupoint;mice;acupoint positioning method;coordinate positioning method;interstitial cystitis
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发布时间：2024-08-13 - 摘要：Objective： To evaluate the pharmacodynamic differences of various oral preparations of Panax Notoginseng Saponins （PNS） on acute blood stasis model rats， and to compare them with commercially available Xueshuantong Capsules （XST） and Sanqitongshu Capsules （SQTS）.MethodsBased on the previous studies， five different oral preparations of PNS including PNS phospholipid complex enteric capsules （PNS-PC）， PNS pH-dependent solid dispersions （PNS-SD）， PNS self-double-emulsifying enteric capsules （PNS-SDEDDS）， PNS bioadhesive microsphere enteric capsules （PNS-BMS）， and N-acetyl-L cysteine modified PNS bioadhesive microsphere enteric capsules （PNS-NAC-BMS） were prepared. Eighty SD rats were randomly divided into the Control group， model （AD） group， XST+AD group， SQTS+AD group， PNS+AD group， PNS-PC+AD group， PNS-SD+AD group， PNS-SDEDDS+AD group， PNS‑BMS+AD group， PNS-NAC-BMS+AD group， 8 rats in each group. The rats in drug administration groups were given the appropriate dose of drug by gavage according to the body mass and drug loading capacity， and the rats in Control and AD groups were given blank capsule by gavage. After 7 d of drug administration， the acute blood stasis model was established in rat by injection of epinephrine hydrochloride combined with ice bath. On the following day， the tongue images and sublingual veins of the rats were photographed to evaluate the tongue condition scores； the tail vein blood was collected to record the tail vein coagulation time； the abdominal aorta blood was collected， and the levels of blood rheological indexes （including whole blood viscosity at different shear rates， Carson’s viscosity， plasma viscosity）， four indexes of coagulation ［including activated partial thromboplastin time （APTT）， prothrombin time （PT）， thrombin time （TT）， fibrinogen （FIB）］， and plasma endothelin （ET）， endothelial-type nitric oxide synthase （eNOS）， 6-keto-prostaglandin F1α （6‑keto-PGF1α） were detected.Results①Compared with the Control group， the rats in AD group had whitish tongue， purple-black sublingual blood vessels， higher tongue condition score （P<0.001）， shorter tail vein coagulation time （P<0.001）， higher levels of whole blood viscosity at different shear rates， Carson's viscosity， and plasma viscosity （P<0.001）， shorter APTT， PT， and TT （P<0.001）， higher levels of FIB and ET （P<0.001）， and lower levels of eNOS and 6-keto-PGF1α （P<0.001）. ②Compared with the AD group， the tongue condition scores of all administration groups were significantly decreased （P<0.001， P<0.01）. Compared with the XST+AD group and the SQTS+AD group， the tongue condition scores of the PNS-PC+AD group， PNS-SDEDDS+AD group， PNS-BMS+AD group and PNS‑NAC-BMS+AD group were also significantly decreased （P<0.05）. ③Compared with the AD group， the tail vein coagulation time of the PNS-PC+AD group， PNS-SDEDDS+AD group， PNS-BMS+AD group， PNS-NAC-BMS+AD group， the PNS+AD group， XST+AD group and SQTS+AD group was obviously prolonged （P<0.001， P<0.01， P<0.05）. Compared with the XST+AD group and SQTS+AD group， the tail vein coagulation time of the PNS-PC+AD group， PNS-SDEDDS+AD group， PNS-BMS+AD group， and PNS-NAC-BMS+AD group was also obviously prolonged （P<0.05）. ④Compared with the AD group， the levels of whole blood viscosity， Carson’s viscosity and plasma viscosity in the five self-prepared PNS oral preparation groups were significantly decreased （P<0.001， P<0.01）， and the levels of whole blood viscosity in the XST+AD group， SQTS+AD group and PNS+AD group， the Carson's viscosity in the XST+AD group， and the plasma viscosity in the PNS+AD group were also decreased （P<0.01， P<0.05）. Compared with the XST+AD group and SQTS+AD group， the whole blood viscosity level of the PNS-PC+AD group was also decreased （P<0.05）. Compared with the SQTS+AD group， the levels of Carson's viscosity in the PNS-PC+AD group， PNS-BMS+AD group and PNS-NAC-BMS+AD group were decreased （P<0.05）. ⑤Compared with the AD group， the APTT and TT were significantly prolonged （P<0.001， P<0.01， P<0.05）， and the FIB levels were significantly reduced （P<0.01） in all administration groups， and the PT was also significantly prolonged in the PNS-PC+AD group， PNS-SDEDDS+AD group， PNS‑BMS+AD group and PNS-NAC-BMS+AD group （P<0.001， P<0.01）. Compared with the XST+AD group and SQTS+AD group， the PT and TT were significantly prolonged （P<0.05） and the levels of FIB were significantly decreased （P<0.01） in the PNS-PC+AD group， PNS‑SDEDDS+AD group， PNS-BMS+AD group and PNS-NAC-BMS+AD group. ⑥Compared with the AD group， the ET levels were significantly decreased （P<0.001， P<0.05） and the levels of eNOS and 6-keto-PGF1α were significantly increased （P<0.001， P<0.01， P<0.05） in all administration groups. Compared with the XST+AD group and the SQTS+AD group， the levels of ET were significantly decreased （P<0.01） and the levels of eNOS were significantly increased （P<0.05） in the PNS-PC+AD group， PNS-SDEDDS+AD group， PNS-BMS+AD group and PNS-NAC-BMS+AD group， the levels of 6-keto-PGF1α were significantly increased in the PNS-PC+AD group， PNS-SD+AD group， PNS-SDEDDS+AD group， PNS-BMS+AD group， and PNS-NAC-BMS+AD group （P<0.01）.ConclusionThe five self-prepared PNS oral preparations， as well as the APIs and XST and SQTS can effectively improve the blood stasis status in rats of acute blood stasis model. While the PNS-PC， PNS-SDEDDS， PNS-BMS and PNS-NAC-BMS are superior to the commercially available two positive medicines and APIs for the improvement of the various indexes related to blood stasis in rats， which have a better prospect for application.关键词：Panax Notoginseng Saponins;oral preparation;model of acute blood stasis;rats;pharmacodynamics
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发布时间：2024-08-13 - 摘要：Objective： To investigate the mechanisms of Cassiae Semen in treating hyperlipidemia based on network pharmacology and be validated through zebrafish experiments.MethodsThe active ingredients and related targets of Cassiae Semen were searched and screened in the Bioinformatics Analysis Tool for Molecular Mechanisms of Traditional Chinese Medicine （BATMAN-TCM） and the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform （TCMSP）. Hyperlipidemia-related target genes were obtained through searching GeneCards， DisGeNET and Online Mendelian Inheritance in man （OMIM）. The common targets of drugs and diseases were obtained by Venny 2.1.0 platform. The Cassiae Semen-active ingredients-potential target network diagram was drawn by Cytoscape3.8.2， the protein-protein interaction （PPI） network diagram was constructed by String database， and the Cassiae Semen-hyperlipidemia common targets were subjected to Gene Ontology （GO） enrichment analysis and Kyoto Encyclopedia of Genes and Genomes （KEGG） pathway enrichment analysis through the Database for Annotation， Visualization and Integrated Discovery （DAVID）. According to the results of the network pharmacology study， aurantio-obtusin （AO） was hypothesized to be the effective acting component of Cassiae Semen in lowering blood lipids， and then the zebrafish experiments were carried out to verify based on above. The zebrafish hyperlipidemia model was induced by high-fat diet with egg yolk liquid， and was treated by AO after modeling， in order to verify the effect and mechanisms of AO in treating hyperlipidemia. Firstly， the toxicity experiment of AO on hyperlipidemic zebrafish was performed to determine the maximum administration concentration of AO. Subsequently， the effects of AO on total cholesterol （TC） and triglyceride （TG） contents and liver histomorphometry of hyperlipidemic zebrafish were observed. Quantitative real-time PCR was used to detect the expressions of core target mRNAs in hyperlipidemic zebrafish.ResultsThirteen active components of Cassiae Semen including AO were obtained. A total of 109 potential targets of Cassiae Semen acting on hyperlipidemia were obtained， including the core targets tumor necrosis factor （TNF）， interleukin （IL）-1β， prostaglandin-endoperoxide synthase 2 （PTGS2） ， Caspase 3 （CASP3）， peroxisome proliferator activated receptor-γ （PPAR-γ）， etc.， which were mainly involved in IL-17 signaling pathway， TNF signaling pathway， as well as lipid and atherosclerosis-related pathways. The results of zebrafish validation experiments showed that， the significant lipid accumulation in zebrafish after modeling occurred， and AO could significantly reduce the TG and TC contents in hyperlipidemic zebrafish tissue （P<0.05， P<0.01）， reduce the fat vacuole and lipid droplet in liver， and significantly down-regulate the expressions of core targets TNF-α and IL-1β mRNA （P<0.01）.ConclusionBased on network pharmacology， the core pathways and targets of Cassiae Semen in the treatment of hyperlipidemia are obtained， and the improvement effect of AO on hyperlipidemia is preliminarily revealed by zebrafish experiments， it may play the therapeutic effect through the core targets such as TNF-α， IL-1β， etc.， in order to provide a reference for the later study of the clinical application of AO in hyperlipidemia.关键词：hyperlipidemia;Cassiae Semen;aurantio-obtusin;network pharmacology;zebrafish
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发布时间：2024-08-13
Experiment Research
- 摘要："Light prescription removing pathogenic factors" belonged to drug classification at the earliest， and later evolved into prescription classification， aiming to use Qingjie Xuansan medicines to treat internal medical diseases. The school of seasonal febrile disease put forward the theory of "reverse transmission into pericardium"， using bamboo leaves， fruit of weeping forsythia， plumule of hindu lotus， rhizome of tatarinowii sweetflag， common trumeric root， stem pith of common rush， etc. to open orifice lightly and clear away heat to promote qi flow， which laid a foundation for light prescriptions in the treatment of heart system diseases. The core pathogenesis of chest blochage and heartache is "weak yang and wiry yin"， wind， cold， heat， poison， wet and other pathogenic factors are related to it， and collaterals are the main disease position. Light prescriptions can disperse yin evil， dispel external evil， and dredge meridians. The light prescriptions contain wind medicine， can open the upper jiao， relieve superficial pathogenic factors to induce sweat， regulate yingqi and weiqi， replenish initial qi， from many aspects to achieve the effects of nourishing heart to expel evil， and dreging meridians to disperse obstruction， in order to treat chest blochage and heartache.关键词：chest blochage and heartache;light prescription removing pathogenic factors;light prescription;wind medicine
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发布时间：2024-08-13 - 摘要：Premature ovarian insufficiency （POI） is a clinical syndrome caused by the decline or even loss of ovarian function in women before the age of 40， and its incidence is rising. At present， there are no curative drugs for treating POI， and hormone replacement therapy is prone to relapse after drug withdrawal and has certain side effects. Acupuncture therapy has unique advantages in treating POI with less adverse reactions. The "kidney-tiangui-chongren-uterus" reproductive axis and xuanfu theory play a key role in the prevention and treatment of gynecological diseases. Starting from the basic theory of traditional Chinese medicine gynecology， taking the reproductive axis as the main line and basing on the xuanfu theory， the treatment attaches attention to regulating the functions of the organs and opening the depression of xuanfu， in order to provide a novel thinking of syndrome differentiation for acupuncture in the treatment of POI.关键词：premature ovarian insufficiency;kidney-tiangui-chongren-uterus;xuanfu theory;acupuncture
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发布时间：2024-08-13
Theoretical Research
- 摘要：Coronary heart disease （CHD） is a heart condition triggered by myocardial ischemia， hypoxia or necrosis due to lumen stenosis， spasm or blockage caused by coronary atherosclerosis. With the change of people's living habits， the incidence of CHD is increasing year by year， seriously endangering human health. According to Chinese traditional medicine， CHD is deficiency in interior and excess in exterior， which belongs to the category of "chest impediment" and "heartache"， and "Yang weakness and Yin excess " is the classic interpretation of CHD. Studies have shown that phlegm and blood stasis are not only the important pathogenic factors of CHD， but also the pathological products. Intermingled phlegm and blood stasis， as the basic pathogenesis throughout the disease， is the main syndrome of CHD. Clinical studies have confirmed that Chinese herbal compound has definite efficacy on CHD with sydrome of intermingled phlegm and blood stasis. This paper consulted the relevant literatures in recent years and summarized and analyzed， it reviewed the research progress of Chinese herbal compound on the treatment of CHD with syndrome of intermingled phlegm and blood stasis from the aspects of classical prescriptions， empirical prescriptions， Chinese herbal compound preparation， combination of Chinese herbal compound and western medicine， and Chinese herbal compound combined with other traditional Chinese medicine therapies， in order to provide some new ideas and beneficial references for the clinical selection of prescription and medication in the treatment of CHD with syndrome of intermingled phlegm and blood stasis.关键词：coronary heart disease;intermingled phlegm and blood stasis;classical prescriptions;empirical prescriptions;Chinese herbal compound preparations
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发布时间：2024-08-13 - 摘要：It is to review the differences in chemical constituents between Lei Fang Kai-Xin-San （KXS） and Ding-Zhi-Xiao-Wan （DZXW）， and the research progress in pharmacological activities such as enhancing learning and memory， anti-oxidation， anti-depression and anti-Alzheimer disease （AD）. The chemical constituents and pharmacological activities of KXS and DZXW were summerized by consulting the related literature. The results showed that the compatibility ratio of medicinal materials of DZXW was changed based on KXS， which led to the change of pharmacological activity. Both KXS and DZXW are widely used in anti-depression， anti-AD， improving learning and memory abilities， anti-aging and anti-fatigue， but their mechanisms are different. Some progress has been made in the study of chemical constituents and pharmacological activities of KXS and DZXW， however， scholars mostly conduct experiments based on basic models to prove the pharmacological effects of KXS and DZXW， but there is few research on the material basis of the efficacy and the mechanism of action， which needs further in-depth study.关键词：Kai-Xin-San;Ding-Zhi-Xiao-Wan;chemical constituents;pharmacological effects;differences
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发布时间：2024-08-13
Review
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