最新刊期
期 5 ， 2023
- 摘要：Brain glioma is an intracranial malignant tumor originating from glial cells. The conventional therapeutic regimen is surgical resection within the maximum safe range， postoperative radiotherapy combined with temozolomide and adjuvant temozolomide for chemotherapy， or adjuvant electric field therapy. However， the clinical effect is still not ideal. In order to fully play the role of traditional Chinese medicine in the treatment of brain glioma and prolong the survival period of patients， Neurosurgery Professional Committee of Shanghai Association of Chinese Integrative Medicine organized relevant domestic experts to reach an expert consensus on the diagnosis and classification of western medicine， differentiation and treatment of traditional Chinese medicine， and western medical treatment of brain glioma by consulting relevant literatures and referring to the clinical experiences of famous doctors of traditional Chinese medicine. The aim is to provide a reference for the clinical diagnosis and treatment of brain glioma.关键词：brain glioma;integrated traditional Chinese and western medicine;diagnosis and treatment;expert consensus;Shanghai
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发布时间：2023-12-02
Expert Consensus
- 摘要：Professor Wang Qingqi has devoted his career to the study of Neijing （Internal Canon of Medicine）. For forty years， he has been consistently studying， teaching， elucidating， practicing and developing Neijing （Internal Canon of Medicine）. His achievements can be summarized as follows： establishing the three-system theory of Neijing （Internal Canon of Medicine）， proposing the cultural genetic theory of Neijing （Internal Canon of Medicine）， pioneering a new field of clinical medicine based on Neijing （Internal Canon of Medicine）， innovating the theory when interpreting Neijing （Internal Canon of Medicine）， and planning for the future development of the academic study of Neijing （Internal Canon of Medicine）.关键词：Neijing （Internal Canon of Medicine）;Wang Qingqi;theory of traditional Chinese medicine
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发布时间：2023-12-02
Scholar Forum
- 摘要：Objective： To systematically and comprehensively evaluate the difference and quality of patchouli oils from different sources， in order to provide a scientific and reliable experimental basis for subsequent studies on the application of patchouli oil.MethodsSteam distillation and supercritical extraction were chosen to prepare patchouli oil， gas chromatography-flame ionization detection （GC-FID） and gas chromatography-mass spectrometry （GC-MS） were used to quantitatively and qualitatively analyze the differences between the two lab-made volatile oils and marketed patchouli oil. The ultra-high performance liquid chromatography-mass spectrometry （UPLC-MS） technique was also applied to perform a non-targeted metabolomics study on three different sources of patchouli oils.ResultsThere approximately 15 chemical components of the three patchouli oils， mainly including sesquiterpenoids and flavonoids and other compounds. There were 184 differential metabolites in three groups. There were significant difference between the supercritical and steam distillation extracted volatile oils， and less difference between the supercritical and the marketed steam distillation extracted volatile oils， and no significant difference in the metabolite content of different batches of commercially available patchouli oils.ConclusionThe chemical composition of lab-made patchouli oil is essentially the same as marketed. Marketed patchouli oil is more stable， so as to provide scientific basis for its subsequent drug development and application.关键词：patchouli oil;GC-MS;non-targeted metabolomics;chemical composition;differential metabolites
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发布时间：2023-12-02 - 摘要：Objective： To establish high performance Liquid chromatography（HPLC） fingerprints of wild and cultivated Paeoniae Radix Rubra from different origins and to evaluate its quality by grey correlation-technique for order preference by similarity to an ideal solutiow（TOPSIS） analysis.MethodsHPLC analysis was performed on Agilent ZORBAX SB-C18 column （4.6 mm×250 mm， 5 μm）， and the mobile phase was acetonitrile （A） - 0.1% phosphate acid （B） for gradient elution. The detection wavelength was 254 nm.ResultsHPLC fingerprints of 30 batches of wild and cultivated Paeoniae Radix Rubra from different origins were obtained， with similarity ranging from 0.821 to 0.989， from which 15 common peaks were calibrated and 11 components were identified， including gallic acid， hydroxypaeoniflorin， catechin， albiflorin， paeoniflorin， ethyl gallate， galloyl paeoniflorin， benzoic acid， 1,2,3,4,6-pentagaloglucose， lactiflorin， benzoyl paeoniflorin. Cluster heatmap analysis showed that the 30 batches of wild and cultivated Paeoniae Radix Rubra from different origins were clustered into three categories. The quality analysis of wild and cultivated Paeoniae Radix Rubra from different origins was performed by grey correlation-TOPSIS. Overall， Hebei wild sample ranked the first and had the best quality， the quality of Hebei cultivated sample and Sichuan cultivated sample is better than that of the left samples， Heilongjiang wild sample， Nei Mongol wild sample， Jilin cultivated sample， Shandong cultivated sample and Anhui cultivated sample ranked behind， Heilongjiang cultivated sample and Nei Mongol cultivated sample had lower ranking with the poor quality. It indicated the regions such as Hebei and Sichuan can be suitable cultivation areas for Paeoniae Radix Rubra.ConclusionThis result can provide reference for quality evaluation of Paeoniae Radix Rubra and also provide the basis for market circulation and planting site selection of Paeoniae Radix Rubra.关键词：Paeoniae Radix Rubra;wild sample;cultivated sample;HPLC fingerprint;grey correlation-TOPSIS;quality evaluation
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发布时间：2023-12-02 -
Specific identification of
Dendrobium huoshanense based on TLC and TLC⁃EFISI⁃MSn combined technology摘要：Objective： To establish a quality control method for qualitative identification thin-layer chromatograph （TLC） of Dendrobium huoshanense C. Z. Tang et S. J. Cheng by thin-layer chromatography （TLC）， and to rapidly identify the specific components of D. huoshanense.MethodsUsing water-saturated n-butanol as the developing agent， TLC was developed at a low temperature of 4 ℃. Using a 2% aluminum chloride-ethanol solution as the chromogenic reagent， the developed TLC plate was heated at 105 ℃ for 5 min， then the specific spots of D. huoshanense were observed under ultraviolet light （365 nm） for authenticity identification. In situ thin-layer chromatography-electrostatic field induced spray ionization-mass spectrometry （TLC-EFISI-MSn） technology was used for rapid structural analysis.ResultsThe specific TLC identification method of D. huoshanense was established. It was found that there was a specific spot in D. huoshanense， which could be used to distinguish D. huoshanense from 13 species of Dendrobium， such as D. officinale and D. devonianum. Furthermore， this method was able to identify more than 20% adulterated D. officinale powder in D. huoshanense powder. According to the relative molecular weight and multi-stage mass spectrometry fragmentation of the compound， the spot was preliminarily identified as the flavonoid compound apigenin‑6‑C‑α‑L‑rhamnosyl‑（1→2）‑β‑D‑glucoside‑8‑C‑α‑L‑arabinose， which is the specific component of D. huoshanense.ConclusionThe established TLC identification method is simple， sensitive， accurate and reliable， with good reproducibility and strong specificity. It provides an experimental basis for improving the quality control method of D. huoshanense， and is of great significance for ensuring its quality and clinical efficacy.关键词：D. huoshanense;thin-layer chromatography （TLC）;thin-layer chromatography-electrostatic field induced spray ionization-mass spectrometry （TLC-EFISI-MSn）;flavonol glycosides;apigenin-6-C-α-L-rhamnosyl-（1→2）-β -D-glucoside-8-C-α-L-arabinose- 6
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发布时间：2023-12-02 - 摘要：Objective： A high performance liquid chromatography （HPLC） method was developed for simultaneous determination of neohesperidin dihydrochalcone（NHDC） and neotame in Kang'erling Granules.MethodsThe Agilent Zorbax SB-Aq （4.6 mm×250 mm） was used for separation and detection， and the mobile phase consisted of acetonitrile-water（21∶79）at a flow rate of 1 mL/min. The detective wavelength was 218 nm and the column temperature was 30 ℃.ResultsNHDC and neotame had good linear relationships （r=0. 999 9） within the range of 1.89~189.00 μg/mL and 4.86~485.60 μg/mL respectively， whose average recovery rates were 97.59% and 102.41% respectively， and RSD<3.00%.ConclusionThis method has good repeatability， high accuracy and simple operation， and can be used for the quality control of NHDC and neotame in food and pharmaceuticals industry.关键词：high performance liquid chromatography;neohesperidin dihydrochalcone;neotame
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发布时间：2023-12-02
Special column on Analysis of traditional Chinese medicine
- 摘要：Objective： To observe the clinical efficacy of Wuling Capsule in the treatment of Parkinson's disease （PD） with sleep disorder.MethodsA total of 168 patients with PD complicated with sleep disorder were collected. On the basis of standard diagnosis and treatment， Wuling Capsule was added for a course of 4 weeks. Before treatment and after 4 weeks of treatment， the scores of PD sleep scale-2 （PDSS2） and the short-form 8-item PD questionnaire （PDQ-8） of all patients were assessed in order to evaluate the clinical efficacy. Meanwhile， the efficacy differences of patients with different sexes， whether taking hypnotic or not， and with different number of chronic diseases were compared.Results①After 4 weeks of treatment， the scores of PDSS2 and PDQ-8 were decreased （P<0.05）. Through the classification and evaluation of sleep disorders， the study found that Wuling Capsule improved sleep related symptoms more significantly （Cohen's d>0.8）. ②After taking Wuling Capsule， the scores of PD related symptoms at night and sleep related symptoms and the total score of PDSS2 were decreased more significantly among patients who took hypnotic； the score of motor related symptoms at night of PDSS2 were decreased the most significantly among patients with ≥3 chronic diseases， and the total score of PDSS2 were decreased the most significantly among patients with 2 chronic diseases.ConclusionWuling Capsule has improvement effect on the sleep related symptoms in patients of PD with sleep disorder， meanwhile Wuling Capsule combined with hypnotic has more significant effect than Wuling Capsule alone.关键词：Parkinson's disease;sleep disorder;Wuling Capsule;multicenter;observational study
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发布时间：2023-12-02 - 摘要：Objective： To observe the effects of Renal Failure Ⅱ Prescription combined with empagliflozin on proteinuria and renal function in patients with chronic kidney disease （CKD） at stages 2-3.MethodsSixty patients of CKD at stages 2-3 with spleen-kidney deficiency and dampness-turbidity-stasis syndrome were included， and randomly divided into the control group （30 cases） and treatment group （30 cases）. The patients in both groups were treated with conventional western medicine. Based on above， the patients in the control group were treated with placebo granule combined with empagliflozin， and the patients in the treatment group were treated with Renal Failure Ⅱ Prescription granule combined with empagliflozin. The treatment course was 3 months. After treatment， the clinical efficacy and the efficacy of traditional Chinese medical syndrome were evaluated and compared between the two groups. Before and after treatment， the levels of serum creatinine （Scr）， uric acid （UA）， blood urine nitrogen （BUN）， estimated glomerular filtration rate （eGFR） and 24 h urinary protein quantification （24 h UPro） in the two groups were detected and compared.Results①After treatment， the total clinical effective rate was 56.67% in the control group and 86.67% in the treatment group， and the curative effect of the treatment group was significantly better than that of the control group （P<0.05）. ②After treatment， the total effective rate of traditional Chinese medical syndrome was 56.67% in the control group and 83.33% in the treatment group， and the curative effect of traditional Chinese medical syndrome in the treatment group was significantly better than that in the control group （P<0.05）. ③After treatment， the levels of Scr， UA and 24 h UPro in the two groups were significantly decreased compared with those before treatment （P<0.05）， the level of eGFR was significantly increased （P<0.05）， the level of BUN in the treatment group was also significantly decreased （P<0.05）， and the level of Scr in the treatment group was significantly lower than that in the control group （P<0.05）， the level of eGFR was significantly higher than that in the control group （P<0.05）.ConclusionRenal Failure Ⅱ Prescription granule combined with empagliflozin can better improve the traditional Chinese medical syndrome and renal function in patients of CKD at stages 2-3 with spleen-kidney deficiency and dampness-turbidity-stasis syndrome， and enhance the clinical efficacy， which has better renal protection effect.关键词：chronic kidney disease;Renal Failure Ⅱ Prescription;empagliflozin;proteinuria;renal function;integrated traditional Chinese and western medicine
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发布时间：2023-12-02 - 摘要：Objective： To analyze the characteristics of pulse graph parameters and its correlation with pain degree in patients of cervical spondylosis with type of qi stagnation and blood stasis， in order to provide the experimental basis for traditional pulse diagnosis theory and modern clinical application.MethodsEighty patients of cervical spondylosis with type of qi stagnation and blood stasis and seventy-six healthy volunteers were included as the patient group and the health group， respectively. The ZM-300 pulse condition instrument was used to collect the pulse graphs of all the subjects， the time-domain parameter values including h1， h3， h4， h5， h3/h1， h4/h1， h5/h1， w， w/t， t1， t4， t5， t， Ad and As were extracted， and the differences between the two groups were analyzed. The visual analogue scale （VAS） score was used to assess the cervical pain degree of the patients， and the correlation between pulse graph parameters and VAS scores of pain was analyzed.ResultsTwo cases in the health group were excluded， finally 74 cases in the health group and 80 cases in the patient group were included in the statistical analysis. ①The values of h1， h3， h4， t5， t and As in the patient group were significantly lower than those in the health group （P<0.05， P<0.01）， and the values of h3/h1 and w/t were significantly higher than those in the health group （P<0.05）. ②The pulse graph parameters h1 and As values of the patient group were negatively correlated with the VAS score （P<0.05， P<0.01）， and the values of w， w/t， h3/h1 and h4/h1 were positively correlated with the VAS score （P<0.05）.ConclusionThe pulse graph parameters of cervical spondylosis patients with type of qi stagnation and blood stasis are altered to a certain extent， reflecting the pulse characteristics of weakened pulse force and increased tension， which is in line with the characteristics of string and thin pulse. It indicates that such patients have weakened cardiac ejection function and low cardiac output， decreased vascular compliance， and increased peripheral resistance. In addition， there is a certain correlation between the pulse graph parameters and the pain degree of the patients.关键词：cervical spondylosis;type of qi stagnation and blood stasis;pulse graph;time-domain parameter;pain degree
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发布时间：2023-12-02
Clinical Research
- 摘要：“Xuxue” can be found in No.237 of “Yangming Disease Chapter” in “Treatise on Febrile Diseases”. In interpreting “Treatise on Febrile Diseases” in later generations， “Xuxue” was classified as a term of syndrome， deriving “TaiyangXuxue” and “YangmingXuxue”. The traditional Chinese medicine planning teaching material “Selected Readings of Treatise on Febrile Diseases” defines “Xuxue” as “blood stagnation”， and in “Dictionary of Treatise on Febrile and Miscellaneous Diseases”， “Xuxue” was interpreted as “blood stasis”， but two explanations can't embody the characteristic of “Xuxue”， which may have the drawback of too broad interpretation. In order to explore the original meaning of “Xuxue” in “Treatise on Febrile Diseases”， from the perspective of Western hermeneutics theory， this paper uses the methods of textual research on the origin and development of versions， textual research on exegetics， homologous literature comparison， deduction fromsyndrome description， reverse testing ontherapy and prescription， and theoretical synthesis of each period to study. After discussion， the original meaning of “Xuxue” should be “long-term blood stasis”， and “blood stasis” should be a derivative meaning.关键词：Xuxue;Treatise on Febrile Diseases;hermeneutics
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发布时间：2023-12-02 - 摘要：The theory “Yang results in Qi， while Yin results in Xing” in The Yellow Emperor's Canon of Internal Medicine contains a profound outlook on life and disease.The dynamic balance between “resulting in Qi” and “resulting in Xing” is the basic guarantee for maintaining normal life activities ofhuman body. Excessive or insufficient of them would lead to diseases. Based on the theory of “Yang results Qi， while Yin results in Xing”， it is believed that unstable angina pectoris is mostly the syndrome of Qi deficiency and blood stasis， and the key pathogenesis is “insufficient Yang resulting in qi and excessive Yin resulting in Xing”. Insufficient “resulting in Qi”prevents the normal generation and distribution of essence and blood， leading toexcessive “resulting in Xing” that shapes stasis， which is angina pectoris. Yiqi Tongmai decoction is a well-known traditional Chinese medicine prescription， commonly used in the treatment of unstable angina pectoris （chest stuffiness and heart pain）.Its purpose oftonifying Qi， warming Yang， promoting blood circulation and dredging meridians tallies with the pathogenesis of “insufficient Yang resulting in qi and excessive Yin resulting in Xing”.关键词：Unstable angina;Yiqi Tongmai decoction;Qi deficiency and blood stasis syndrome;basic theory of traditional Chinese medicine
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发布时间：2023-12-02
Theoretical Research
- 摘要：Melittin （MEL） is the main component of bee venom and has unique advantages in the treatment of cancers and other diseases. However， due to the strong toxic and side effects of MEL， its drug development and clinical application have been hindered. Recent pharmacological studies have shown that MEL not only has strong cell membrane surface activity and hemolytic activity， but also has good biological activity and pharmacological effects， including antibacterial， antiviral， anti-inflammatory， anti-tumor， anti-fibrosis and so on. In addition， many strategies have also been adopted in the MEL drug delivery systems， such as improving MEL and its conjugates， and using nano-delivery vehicles. This article reviews the research progress of MEL's pharmacology and nano-delivery system in order to provide reference for the future research of MEL.关键词：melittin;pharmacology;nano-delivery system;anti-tumor;anti-inflammatory
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发布时间：2023-12-02 - 摘要：Burning mouth syndrome （BMS） is mainly manifested as glossodynia and burning pain in the oral mucosa， with the majority of patients being female， mainly in postmenopausal women. At present， there is a lack of effective and systematic therapeutic regimens to treat BMS. It's more common to adopt methods of symptomatic treatment and anxiolytic treatment combined with psychotherapy in western medicine. Meanwhile， the disease falls into the category of “tongue impediment”， “tongue numbness” and “glossodynia” in traditional Chinese medicine（TCM）. In addition， the tongue is closely related to the internal organs embracing heart， spleen， and small intestine. Apart from Chinese medicine decoction， there are various specific treatments in TCM. However， a large number of clinical observations are required to carry on due to a lack of certain evidence-supported clinical treatments and objective efficacy evaluation indicators.关键词：Burning mouth syndrome;pathogenesis;traditional Chinese medicine and western medicine therapies
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发布时间：2023-12-02 - 摘要：Myofascial trigger points （MTrPs） theory is a new research hotspot and treatment direction. The clinical research of MTrPs is in a period of vigorous development， which is effective in the treatment of pain diseases. In clinical practice， the types of pain related diseases in obstetrics and gynecology are complex， unclear etidogy， long treatment cycle， easy to relapse， and poor prognosis. Therefore， it is urgent to explore multi-angle， multi-dimensional and comprehensive treatment programs. In recent years， it has been found that MTrPs technology has its unique advantages in the treatment of gynecological diseases. This paper reviews the clinical research progress of MTrPs theory combined with muscle stretching exercise in the treatment of primary dysmenorrhea， chronic pelvic pain， ovarian cyst and postpartum related diseases at home and abroad， in order to provide reference for clinical research based on myofascial trigger theory and provide ideas for clinical treatment of related obstetrical and gynecologyical diseases.关键词：myofascial trigger points;obstetrics and gynecology disease
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发布时间：2023-12-02
Review
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