最新刊期
期 2 ， 2023
- 摘要：Based on the core pathogenesis of blood stasis due to qi deficiency in post-hepatitis cirrhosis and the main syndrome pathogenesis of yin deficiency of the liver and kidney， and damp-heat brewing internally， a comparative study on the efficacy of multiple models of cirrhosis with different efficacy of traditional Chinese medicine （TCM） formulas， to demonstrate that the kidney and liver nourishing formula Yiguanjian had a prominent effect on hepatocyte damage dominated liver cirrhosis model. Yiguanjian can significantly improve the Child-Pugh score of patients with yin deficiency of the liver and kidney in decompensated hepatitis B cirrhosis. In-depth studies have showed that the main mechanisms of Yiguanjian in the treatment of cirrhosis are to improve the attenuation of hepatic parenchymal cells， regulate stem cell differentiation to promote liver regeneration， improve the hypoxia state of liver tissue， inhibit the damage of hepatic sinusoidal endothelial cells and angiogenesis， and improve the inflammatory microenvironment. Based on the theory of “disease-formula （effect）-syndrome”， it is believed that the key pathological basis of liver and kidney yin deficiency syndrome in cirrhosis is related to hepatic parenchymal cell attenuation， liver regeneration disorder， liver tissue hypoxia， hepatic sinus endothelial injury and angiogenesis， as well as macrophage-dominated inflammatory microenvironment lesions. It is suggested that strengthening the basic research of pathobiology of formula and syndrome may be the breakthrough of TCM treatment of chronic refractory diseases.关键词：syndrome pathogenesis;pathology of formula and syndrome;liver cirrhosis;Yiguanjian;hepatocyte attenuation;liver regeneration;hepatic sinusoidal endothelial cells
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发布时间：2023-03-24
Scholar Forum
- 摘要：Objective： To study the inhibitory effect of Panax quinquefolium saponin from stems and leaves （PQS） on the inflammatory activation of mouse BV-2 microglia induced by oxygen-glucose deprivation/reoxygenation （OGD/R）， and to elucidate its mechanism.MethodsBV-2 cells were divided into the control group， OGD/R group and PQS low， medium， high dose+OGD/R group. The cells in control group were cultured under conventional condition； the cells in OGD/R group were cultured under OGD/R condition； the cells in PQS low， medium， high dose+OGD/R group were pretreated with PQS （30， 60， 90 μg/mL）， then cultured in OGD/R condition. The cells were cultured for 48 h， then the contents of inflammatory factors such as tumor necrosis factor-α （TNF-α）， interleukin-1β（IL-1β） and IL-6 in the cell supernatant were detected by ELISA. The proliferative activity was detected by CCK-8 method， the expression of glial activation marker protein ion calcium-binding adapter molecule 1 （Iba-1） and acid lysozyme glycoprotein （CD68） were detected by flow cytometry， and the phosphorylation of nuclear factor-κB （NF-κB） p65 and its inhibitory factors NF-κB inhibitory protein α （IBK-α） as well as NF-κB inhibitory factor （NKRF） were detected by Western blot.ResultsOGD/R induction could significantly increase the contents of inflammatory factors such as TNF-ɑ， IL-1β and IL-6 in the supernatant of BV-2 cells （P<0.01）， enhance the proliferation activity of BV-2 cells （P<0.01）， up-regulate the expression of CD68 and the phosphorylation of NF-κB-p65 （P<0.01）， and down-regulate the expression of Iba-1 and NKRF （P<0.01）. PQS pretreatment could effectively reverse the change trend of the above indexes caused by OGD/R in BV-2 cells， and the effects were concentration-gradient dependent （P<0.05，P<0.01）. In addition， there was no significant difference in the expression of IκB-α protein in BV-2 cells among all groups （P>0.05）.ConclusionPQS can inhibit the inflammatory activation of BV-2 cells induced by OGD/R， and its mechanism may be related to the up-regulation of NKRF protein expression.关键词：Panax quinquefolius saponin from stems and leaves;OGD/R;microglia;inflammatory activation;NKRF
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发布时间：2023-03-24 - 摘要：Objective： To observe the intervention effect and possible mechanism of berbamine （BBM） on ulcerative colitis （UC） mice induced by dextran sulfate sodium （DSS）.Methods①RAW264.7 macrophage inflammation model was used to investigate the effect of BBM on its cell viability， nitric oxide （NO） release， and the expression of tumor necrosis factor-α （TNF-α）， interleukin-1β （IL-1β）， IL-6 and inducible NO synthase （iNOS） inflammatory genes. ②Male C57BL/6 mice were randomly divided into normal group， model group， BBM group （50 mg/kg） and sulfasalazine （SASP） positive group （250 mg/kg）， with 8 mice in each group. DSS induced UC mouse model was established， and corresponding drugs were given by gavage for 9 d consecutively. The body mass， spleen coefficient， colon length and appearance of the mice were recorded， disease activity index was evaluated， and pathological injury of colon was observed by HE staining. The expression of inflammatory genes TNF-α， IL-1 β， IL-6 and iNOS in the colon of mice were detected by RT-qPCR and the expression of tight junction proteins Claudin-4 and Occludin as well as JAK2/STAT3 pathway proteins were detected by Western blot.Results①BBM had no effect on RAW264.7 cells viability， but could reduce the NO release （P<0.05，P<0.01） and the expression of inflammatory genes TNF-α， IL-1β， IL-6 and iNOS in a dose-dependent manner （P<0.05，P<0.01）. ②BBM could improve the body mass loss and spleen coefficient increase of UC mice （P<0.05）， inhibit the shortening of the colon （P<0.05）， decrease the score of disease activity index and improve the pathological injury of colon in mice （P<0.05）. ③BBM could reduce the expression of inflammatory genes TNF-α， IL-1 β， IL-6 and iNOS in the colon of mice （P<0.05，P<0.01）. ④BBM could increase the expression of Claudin-4 and Occludin， and reduce the phosphorylation of JAK2 and STAT3 in the colon of mice （P<0.05，P<0.01）.ConclusionBBM can improve UC in mice induced by DSS， its mechanism may be related to the inhibition of JAK2/STAT3 signal pathway and the reduction of inflammatory genes expression， thus enhancing the intestinal mucosal barrier function.关键词：berbamine;ulcerative colitis;JAK2/STAT3 signal pathway
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发布时间：2023-03-24 - 摘要：Acupuncture is one of the commonly used methods to prevent and treat asthma， and its efficacy is definite， but its biological mechanism is very complicated. In order to elucidate the specific mechanism of acupuncture treatment of asthma， the effects of acupuncture on airway inflammation， lung histopathology and respiratory function in asthma models and their possible mechanisms were collated and summarized， and it was found that acupuncture could significantly improve the number of inflammatory cells， lung histopathological changes and elevated airway resistance in asthma models. However， the existing animal models and research tools of acupuncture asthma are relatively single， suggesting that future basic research on acupuncture asthma should construct animal model matching syndromes of traditional Chinese medicine， and the mechanism research methods should be diversified.关键词：acupuncture;bronchial asthma;animal models;inflammation;airway resistance
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发布时间：2023-03-24
Special column on anti-inflammatory of traditional Chinese medicine
- 摘要：Objective： To analyze the characteristics of traditional Chinese medicine （TCM） symptoms in patients of mild novel coronavirus omicron variant infection combined with type 2 diabetes mellitus who met the discharge criteria and observe the intervention effect of Jingyin Gubiao Formula.MethodsA total of 790 patients with corona virus disease 2019 （COVID-19） who met the criteria when discharged from the hospital were randomly divided into the treatment group and the control group at a ratio of 1∶1， 395 cases in each group. In the treatment group， 146 patients who met the diagnostic criteria of type 2 diabetes mellitus were enrolled in the diabetic treatment group， and the other 249 patients were enrolled in the non-diabetic treatment group. In the control group， 129 patients who met the diagnostic criteria of type 2 diabetes mellitus were enrolled in the diabetic control group， and the other 266 patients were enrolled in the non-diabetic control group. When discharged from the hospital， the patients in the treatment group were given Jingyin Gubiao Formula orally with a course of 1 week， while the patients in the control group were not given any medicine. The TCM symptom scores of the patients when discharged from the hospital were compared between the diabetic treatment group and the non-diabetic treatment group. Before and after treatment of Jingyin Gubiao Decoction ， the TCM symptom scores were compared between the diabetic treatment group and the diabetic control group. If the baseline data were not balanced between the two groups， the indicators with differences were taken as the covariates to perform the propensity score matching in order to obtain the balanced data between the two groups， and then the TCM symptom scores were compared between the two groups.Results①When the patients were discharged from the hospital， except for wheezing symptom， the other TCM symptoms in the non-diabetic treatment group were milder than those in the diabetic treatment group （P<0.01， P<0.05）. ②After treatment， all the TCM symptoms in the diabetic treatment group were significantly improved compared with those before treatment （P<0.01， P<0.05）， the symptoms including aversion to cold， sweating， headache， cough and sore throat in the diabetic control group were also significantly improved compared with those before treatment （P<0.01， P<0.05）， and the improvement of the symptoms including aversion to cold， sweating， cough and expectoration in the diabetic treatment group were better than those in the diabetic control group （P<0.01， P<0.05）.ConclusionCompared with the non-diabetic patients， the patients of mild novel coronavirus omicron variant infection combined with type 2 diabetes mellitus still have more severe pulmonary symptoms even when they met the discharge criteria， and Jingyin Gubiao Formula has a certain effect on improving these symptoms.关键词：type 2 diabetes mellitus;COVID-19;omicron variant;traditional Chinese medicine symptoms;Jingyin Gubiao Formula;Shanghai
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发布时间：2023-03-24 - 摘要：Objective： To evaluate the efficacy of moxibustion on Du meridian in the treatment of cerebral infarction （CI） in recovery period by multicenter randomized controlled study.MethodsA total of 212 patients with CI in recovery period were included and randomly divided into the control group and treatment group， 106 cases in each group. The patients in both groups were treated with conventional therapy. Based on above， the patients in the treatment group were treated with moxibustion on Du meridian. The treatment course was 12 weeks. The clinical efficacy of the two groups was evaluated and compared. Before and after treatment， the scores of National Institutes of Health Stroke Scale （NIHSS） and Barthel Index （BI） were evaluated， and the levels of Neuron-specific enolase （NSE）， immunoglobulin （Ig）A， IgG， IgM， interleukin （IL）-6 and tumor necrosis factor-α （TNF-α） were detected.ResultsDuring the treatment， 7 patients in the control group and 7 patients in the treatment group were excluded or dropped out. Finally， 99 cases in the control group and 99 cases in the treatment group were included in the statistical analysis. ①After treatment， the clinical total effective rate was 79.8% in the treatment group and 61.6% in the control group， and the efficacy of the treatment group was better than that of the control group （P<0.05）. ②After treatment， the NIHSS scores in the two groups were significantly decreased compared with those before treatment （P<0.05）， and the BI scores were significantly increased compared with those before treatment （P<0.05）. Additionally， the NIHSS score of the treatment group was lower than that of the control group and the BI score was higher than that of the control group （P<0.05）. ③After treatment， the levels of NSE and TNF-α in the treatment group were significantly decreased compared with those before treatment （P<0.05）， and were lower than those in the control group （P<0.05）. The level of IgG in the treatment group was increased compared with that before treatment （P<0.05）， and were higher than that in the control group （P<0.05）.ConclusionMoxibustion on Du meridian can improve the neurological deficits and enhance the activity of daily living in treating patients with CI in recovery period. Its mechanisms may be related to regulating the immune function， reducing the levels of inflammatory factors and alleviating brain injury.关键词：cerebral infarction;recovery period;moxibustion;Du meridian;immune index;inflammatory factor;nerve function injury
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发布时间：2023-03-24 - 摘要：Objective： To evaluate the clinical efficacy of Jiedu Tongluo Huashi Formula combined with hydroxychloroquine tablet in treating patients with primary Sjögren’s syndrome （pSS） without visceral involvement of damp-heat type， in order to seek a new method for the treatment of pSS.MethodsA randomized double-blind controlled study was applied. A total of 86 patients with pSS without visceral involvement of damp-heat type were included and divided into the treatment group （43 cases） and control group （43 cases）. The patients in the treatment group were treated with Jiedu Tongluo Huashi Formula combined with hydroxychloroquine tablet orally， and the patients in the control group were treated with placebo combined with hydroxychloroquine tablet orally， with a course of 12 weeks. The clinical efficacy of the two groups was evaluated， and patient-acceptable symptom state （PASS） and minimal clinically important improvement （MCII） compliance rates were used to further determine the clinical efficacy. Before and after treatment， the total score of Chinese medical syndrome， the EULAR Sjögren’s syndrome patient reported index （ESSPRI） score， EULAR Sjögren’s syndrome disease activity index （ESSDAI） score in the two groups were evaluated and compared. The salivary flow rate in the unstimulated state was applied to estimate the dry mouth status of the patients， and the Schirmer’s test and BUT test were applied to estimate the dry eye status of the patients. Before and after treatment， the levels of serum immunoglobulin （Ig） G， complement C3， complement C4 and peripheral blood CXC-chemokine ligand 13（CXCL13） expression were detected and compared.ResultsDuring the study， 2 patients in the treatment group and 3 patients in the control group were excluded or shed off. Finally， 41 cases in the treatment group and 40 cases in the control group were included in the statistical analysis. ①After treatment， the total clinical effective rate was 82.93% in the treatment group and 60.00% in the control group， and the effect of the treatment group was significantly better than that of the control group （P<0.01）. ②After treatment， the ratio of the patients achieving PASS in the two groups was significantly increased compared with that before treatment （P<0.05， P<0.01）， while there was no statistically significant difference between the two groups （P>0.05）. After treatment， the ratio of the patients achieving MCII according to ESSPRI in the treatment group was significantly increased compared with that in the control group （P<0.05）. ③After treatment， the total scores of Chinese medical syndrome in the two groups were significantly decreased compared with those before treatment （P<0.05， P<0.01）， and the reduction degree of the score in the treatment group was superior to the control group （P<0.05）. ④After treatment， the ESSPRI score and the scores of dry， fatigue and pain dimensions in the treatment group were significantly decreased compared with those before treatment （P<0.05， P<0.01）， the ESSPRI score and the score of pain dimension in the control group were also significantly decreased compared with those before treatment （P<0.05）， and the reduction degree of ESSPRI score and the scores of dry and fatigue dimensions in the treatment group were superior to the control group （P<0.05）. ⑤After treatment， the scores of ESSDAI in the two groups were significantly decreased compared with those before treatment （P<0.05， P<0.01）， while there was no statistically significant difference on the reduction degree of the score between the two groups （P>0.05）. ⑥After treatment， the salivary flow rate in the unstimulated state of the two groups was increased compared with that before treatment （P<0.05， P<0.01）， while there was no statistically significant difference on the elevation degree between the two groups （P>0.05）.⑦After treatment， the levels of IgG and CXCL13 in the treatment group were significantly decreased compared with those before treatment （P<0.01）， and the reduction degree of CXCL13 level in the treatment group was superior to the control group （P<0.05）.ConclusionJiedu Tongluo Huashi Formula combined with hydroxychloroquine tablet can effectively improve the subjective symptoms and objective indicators in treating patients with pSS， and its effect may be related to inhibiting CXCL13 to improve gland function and reducing the disease activity of pSS.关键词：primary Sjogren’s syndrome;damp-heat type;Jiedu Tongluo Huashi Formula;randomized double-blind controlled trial
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发布时间：2023-03-24 - 摘要：Objective： To observe the clinical efficacy of Chuanhuang Formula in treating patients with chronic kidney disease （CKD） at stages 3-4， and explore its influence on the levels of urinary interleukin-18 （IL-18） and γ-glutamyl transferase （γ-GT）.MethodsA total of 70 patients with CKD at stages 3-4 who met the criteria were randomly divided into the treatment group and control group according to 1∶1 ratio， 35 cases in each group. The patients in the control group were treated with conventional western medicine. The patients in the treatment group were treated with Chuanhuang Formula orally based on the treatment of the control group. The treatment course was 12 weeks. The clinical efficacy of the two groups was evaluated. The total scores of Chinese medical syndrome in the two groups were evaluated and compared before and after treatment. The levels of renal function indexes ［including serum creatinine （Scr）， blood urea nitrogen （BUN）， uric acid （UA） and estimated glomerular filtration rate （eGFR）］， acute kidney injury （AKI） markers （including urinary IL-18 and γ-GT） and 24-hour urinary protein quantification （24 h U-Pro） were detected.Results①After treatment， the total clinical effective rate was 68.5% in the treatment group and 42.8% in the control group， and the effect of the treatment group was better than that of the control group （P˂0.01）. ②After treatment， the total scores of Chinese medical syndrome in the two groups were significantly decreased compared with those before treatment （P<0.01）， and the score of the treatment group was lower than that of the control group （P<0.05）. ③After treatment， the level of eGFR in the two groups was increased compared with that before treatment （P˂0.01）， the levels of Scr and BUN were decreased compared with those before treatment （P˂0.01）， and the level of eGFR in the treatment group was higher than that in the control group （P˂0.05）， the levels of Scr and BUN were lower than those in the control group （P˂0.05）. ④After treatment， the level of 24 h U-Pro in the treatment group was significantly decreased compared with that before treatment （P<0.01）， and was lower than that in the control group （P<0.05）， while there was no statistically significant difference on the level of 24 h U-Pro in the control group between before and after treatment （P>0.05）. ⑤After treatment， the levels of urinary IL-18 and γ-GT in the treatment group were decreased compared with those before treatment （P<0.01）， the level of urinary IL-18 in the control group was also decreased compared with that before treatment （P<0.01）， and the levels of urinary IL-18 and γ-GT in the treatment group were lower than those in the control group （P<0.05）.ConclusionCompared with conventional western medicine only， Chuanhuang Formula combined with conventional western medicine could better protect the renal function， promote the recovery of the renal function， improve the Chinese medical syndrome， and reduce the levels of urinary IL-18 and γ-GT in patients with CKD at stages 3-4.关键词：chronic kidney disease;Chuanhuang Formula;interleukin-18;γ-glutamyl transferase;markers of acute kidney injury
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发布时间：2023-03-24
Clinical Research
- 摘要：Objective： To establish high performance liquid chromatography（HPLC） fingerprint and content determination method of Gleditsiae Spina Dispensing Granules， and to provide reference for their quality control and evaluation.MethodsThe HPLC fingerprint of Gleditsiae Spina Dispensing Granules was established and the content of the index component protocatechuic acid was determined by HPLC. The chromatographic separation was performed on a Shiseido MG C18 column（4.6 mm×250 mm， 5 μm） with acetonitrile-0.2% phosphoric acid aqueous solution as the mobile phase for a gradient elution. The detection wavelength was set at 260 nm with a flow rate of 1.0 mL/min and a column temperature at 35 ℃.ResultsThere were 5 common peaks in all fingerprint spectra of Gleditsiae Spina Dispensing Granules， and the peaks 2， 4 and 5 were identified as protocatechuic acid， p-hydroxybenzoic acid and vanillic acid respectively. The similarity of 10 batches of Gleditsiae Spina Dispensing Granules from the same manufacturer was ranged from 0.814 to 1.000， with the contents of protocatechuic acid from 2.28 to 2.60 mg/g. However， the similarity of Gleditsiae Spina Dispensing Granules from different manufacturers varied greatly with the similarity ranged from 0.580 to 0.956， and the contents of protocatechuic acid from 0.26 to 2.60 mg/g.ConclusionThe established HPLC fingerprint and content determination method are simple， feasible and reproducible， and can be used for the quality evaluation and control of Gleditsiae Spina Dispensing Granules.关键词：Gleditsiae Spina;dispensing granules;HPLC fingerprint;content determination;protocatechuic acid
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发布时间：2023-03-24 - 摘要：Objective： To evaluate the pre-clinical safety of the prepared Yiqi Huoxue Gel Patch and to investigate its therapeutic effect on diabetic peripheral neuropathy rats.MethodsHealthy rabbits， guinea pigs and normal Wistar rats were selected to investigate the effect of Yiqi Huoxue Gel Patch on skin irritation in rabbits， skin irritability in guinea pigs and acute toxicity in rats after administration， and to evaluate the safety of Yiqi Tongluo Gel Patch on skin. Adult male Wistar rats were divided into normal group and model group. The rats in model group were induced by high-fat diet and streptozotocin to establish a model of diabetic peripheral neuropathy. The rats in model group were randomly divided into 3 groups： model group， Yiqi Huoxue Gel Patch low-dose and high-dose groups. The normal group was used as the blank control group， and the rats in the blank control group and model control group were given gel matrix， the rats in the Yiqi Huoxue Gel Patch groups were treated with low-dose and high-dose Yiqi Huoxue Gel Patch， once a day for 14 consecutive days. After the last intervention， the sensory nerve and motor nerve conduction of rats in each group were tested to investigate the effect of Yiqi Huoxue Gel Patch on the latency and conduction velocity of motor nerve and sensory nerve in rats with diabetic peripheral neuropathy.ResultsYiqi Huoxue Gel Patch had no irritation to the skin of healthy rabbits， no allergy to the skin of healthy guinea pigs and no acute toxicity to rats. Compared with the model group， the latencies of sensory nerve and motor nerve in Yiqi Huoxue Gel Patch low-dose and high-dose group were significantly shortened， and the conduction velocities were significantly increased.ConclusionYiqi Huoxue Gel Patch is safe for skin use and can improve diabetic peripheral neuropathy in rats. The research results provided an important foundation for the application and development of this patch.关键词：method of Yiqi Huoxue;gel patch;safety evaluation;diabetic peripheral neuropathy
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发布时间：2023-03-24
Experiment Research
- 摘要：Ulcerative colitis （UC） is a chronic inflammatory disease occurring in the colorectal， and its specific pathogenesis is unknown. UC is one of the intractable diseases worldwide. Modern medicine believes that the pathogenesis of UC is related to family inheritance， living habits， inflammatory immune factors， intestinal microbial environment and intestinal mucosal barrier， etc. The main treatments of UC include medication to control inflammation， promote mucosal healing and surgery. Traditional Chinese medicine believes that its pathogenesis is based on the weakness of the spleen and stomach， and various treatments such as orad administration of traditional Chinese medicine， acupuncture and moxibustion， and enemas are adopted. In recent years， traditional Chinese medicine， Western medicine and the combination of both in the treatment of UC has a remarkable clinical effect， which can significantly reduce intestinal inflammation and relieve symptoms. It is necessary to further explore the treatment mechanism， effectively combine traditional Chinese and Western medicine treatment measures， and improve the phased treatment of UC.关键词：ulcerative colitis;pathogenesis;treatment method;combination of Chinese and western medicine
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发布时间：2023-03-24 - 摘要：Through visual analysis of the literatures on acupuncture treatment of breast cancer， to explore the development status， research hotspots， and dynamic frontier of this field in the recent 20 years. Taking the relevant literature collected in the core collection of Web of Science （WOS） from 2002 to 2021 as the object， CiteSpace was used to analyze the distribution of publishing trends， authors， country institutions， literature co-citations and hot spots in the research field， and to draw the relevant visual maps. The results show that acupuncture therapy in breast cancer has good prospects， which is focus on clinical trials. At present， several clinical trials have been carried out to verify the efficacy and safety of acupuncture therapy in the treatment of breast cancer-related symptoms. In the future， more rigorous and well-designed clinical trials can be carried out， and the research on the mechanism of acupuncture in the treatment of breast cancer can be strengthened， which is of great significance to promote the application of acupuncture therapy and improve the life quality of breast cancer patients.关键词：acupuncture therapy;breast cancer;visual analysis;CiteSpace;Web of Science （WOS）
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发布时间：2023-03-24
Theoretical Research
- 摘要：Uridine diphosphate （UDP）-sugar donors are key precursors for glycosylation modification of active ingredients of traditional Chinese medicine， such as triterpenoids， flavonoids， and anthraquinones. In recent years， some progress has been made in the synthesis of glycosides by metabolic engineering strategies， but the low yield of UDP-sugar donors in various chassis cells limits the efficient biosynthesis of traditional Chinese medicine glycosides. In this review， the research progress in the supply of UDP-sugar donors in the synthesis of glycosides were reviewed from the aspects of biosynthesis， recycling and regeneration of UDP-sugar donors as well as the regulation of key genes in the metabolic synthesis pathway and optimization of metabolic modules. Furthermore， research challenges and development directions of UDP-sugar donors in glycosides biosynthesis were discussed， in order to provide a reference for further research on glycoside biosynthesis.关键词：UDP-sugar donors;glycosides;metabolic regulation;biosynthesis
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发布时间：2023-03-24 - 摘要：The “Jingui Yaolue” in the Han Dynasty recorded Zaojiawan Formula was a pellet made from a single Chinese medicine Gleditsia sinensis Lam. by stir-heating with animal butter， and Gleditsia sinensis Lam. is the Gleditsiae Sinensis Fructus. In order to excavate and inherit the processing technology of Gleditsiae Sinensis Fructus and guide the clinical rational application of processed drugs， the evolution tends of the name， processing methods， properties and efficacy of Gleditsiae Sinensis Fructus were intuitively analyzed in this paper through reviewing 180 related ancient Chinese medicine books （including 46 for discourses on prescription， 40 for miscellanies， 23 for herbals， 20 for gynecology and pediatrics， 15 for typhoid fever and Jingui， 3 for diagnosis， 3 for medical cases and so on）， as well as the previous editions of the Chinese Pharmacopoeia and 48 editions of local processing specifications by visual thinking. According to literature research， the historical processing methods of Gleditsiae Sinensis Fructus without auxiliary materials included peeling and deseeding， smashing， filing， hammering， burning， grinding into fine powder， stir-heating， frying with high heat， frying， simmering， baking， calcining， boiling to paste and so on； while the methods adding auxiliary materials included processing with animal butter， wine， salt （including salt soaking and salt frying）， vinegar， honey， children piss， bran frying， oil and so on. The modern processed products are mainly raw products， and the methods of charring or frying of Gleditsiae Sinensis Fructus are recorded in the local processing specifications only in some places. The 2020 edition of the Chinese Pharmacopoeia records Gleditsiae Sinensis Fructus has the efficacy of dissipating phlegm for resuscitation and dissipating nodules and detumescence， which is basically consistent with that recorded in the traditional herbals. This paper analyzed the historical context of the processing of Gleditsiae Sinensis Fructus from the perspective of visualization， sorted and summarized the evolution of properties and efficacy of Gleditsiae Sinensis Fructus from ancient to present， providing reference for the subsequent processing study of Gleditsiae Sinensis Fructus and the rational clinical application of its processed products.关键词：Gleditsiae Sinensis Fructus;name;processing methods;properties and efficacy;historical evolution
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发布时间：2023-03-24
Review
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