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Issue 6 ， 2022
- Abstract：The evaluation of innovation ability （EIA） is the basic function and effective guarantee of the scientific and technological innovation （STI） system of traditional Chinese medicine （TCM）. Based on synthesizing the research results in relevant fields， this paper briefly discussed the purpose， significance， principles， methods and system framework of the evaluation of STI ability of TCM （ESTIA-TCM）， and proposed that a scientific and reasonable system of ESTIA-TCM should be established as soon as possible to promote the development of TCM inheritance and innovation.Keywords：traditional Chinese medicine;scientific and technological innovation;evaluation
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Published：2022-11-26
Scholar Forum
- Abstract：Objective： Based on the third-generation PacBio sequencing technology， to establish a full-length sequence database of Ganoderma and edible fungi rRNA 18S-ITS-28S， and to identify species quickly and accurately at the molecular level.MethodsDNA was extracted from 8 kinds of edible fungi and 1 kind of Ganoderma lucidum which previously collected， and used primers to amplify the full-length sequence of 18S-ITS-28S. The full-length sequence of 18S-ITS-28S included continuous and complete 18S rRNA， 5.8S rRNA and partial 28S rRNA sequence， the total length is longer than 3.3 kb， the PacBio third-generation sequenceing was used to measure the full-length sequence of each sample 18S-ITS-28S samples and construct library.ResultsThe 18S rRNA， 5.8S rRNA， and partial 28S rRNA genes of edible fungi and medicinal Ganoderma lucidum were highly similar and conserved. The rRNA genes （ITS1 and ITS2） were significantly different.ConclusionThe results of this study suggest that the analysis of rRNA intergenic （ITSs） regions， instead of only the analysis of rRNA genes， is helpful for the identification and research of fungal Chinese medicinal materials.Keywords：Ganoderma;edible fungus;rRNA gene;sequencing analysis;identification
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Published：2022-11-26 - Abstract：Objective： To conduct the pharmacognosy research on Sinomenii Caulis， and its four adulterants from the aspects of morphological identification and microscopic identification to provide reference for solving the problem of variety confusion of Sinomenii Caulis.MethodOptical microscope， stereoscope and other equipments were used to systematically observe and compare the traits， micro traits， normal light microscopic identification and polarized light microscopic identification of 25 batches Caulis Sinomenii and its four adulterants. Holographic color image data were collected by large image stitching technology and real-time depth of field expansion technology， and the morphological identification characteristics of Sinomenii Caulis and its adulterants were studied entirely from marcocosm to microcosm.ResultThe traits of Sinomenii Caulis and its adulterants and the holographic color images of their tissue cross-sections and powders under normal light microscope and polarized light microscope were obtained. An identification key was created for rapid identification on traits， microscopic cross-sections and powders of Sinomenii Caulis and its adulterants. Sinomenii Caulis and its adulterants can be quickly distinguished by the types and distribution patterns of calcium oxalate crystals in their cross-sectional cortex and phloem tissue.ConclusionThe holographic color images of the cross-section of Sinomenii Caulis can clearly identify Sinomenii Caulis and its adulterants under polarized light. Whether calcium oxalate crystals exist and their existence forms， and whether sclereid exists under polarized light can be used to quickly distinguish powder of Caulis Sinomenii and its adulterants.Keywords：Sinomenii Caulis;pharmacognosy;trait;microscope;polarized light
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Published：2022-11-26 - Abstract：ObjectiveTo investigate the mainstream varieties of Tibetan medicine “Jieji Gaobao” from Sichuan and Gansu in China， and study the method of molecular pharmacognosy identification based on DNA barcoding.MethodsAn ethnobotanical survey of “Jieji Gabao” in Sichuan and Gansu was carried out and 55 samples from 11 populations were collected. The origin， medicinal material morphological and microscopic identification as well as quality evaluation of Jieji Gaobao were carried out. Based on our previous work， the DNA molecular markers were further screened. The sequences of chloroplast genome psbA⁃trnH， rpl20⁃rps12 and mitochondrial genome nad1 b/c in each sample and 9 related species of Gentiana Sect. Cruciata. The phylogenetic tree was constructed by neighbor-joining method with Halenia elliptica （Gentianaceae） and Gentiana erecto⁃sepala （Gentiana Sect. Frigidat） as the outgroups. Then the phylogenetic significances of each fragment were evaluated and DNA barcodes were constructed.Results①Gentiana straminea （Gentianaceae Gentiana） from Sichuan and Gansu is the mainstream variety of Tibetan medicine Jieji Gabao. ②The total content of gentiopicroside and loganic acid in each sample meets the standard of Chinese Pharmacopoeia. ③The chloroplast psbA⁃trnH sequence could divide the 10 species into two groups， with Gentiana straminea and Gentiana robusta in one group and the other 8 related species in another group； the mitochondrial nad1 b/c sequence could further distinguish Gentiana straminea and Gentiana robusta； the chloroplast rpl20⁃rps12 sequence had the resolution between different origin. Therefore， the combinational DNA barcodes based on chloroplast psbA⁃trnH， mitochondrial nad1 b/c， and chloroplast rpl20⁃rps12 were constructed for Gentiana straminea， the mainstream Tibetan medicine “Jieji Gabao” from Sichuan and Gansu.ConclusionIn this study， the origin of the mainstream varieties of Tibetan medicine Jieji Gabao from Sichuan and Gansu were clarified， and its identification method based on DNA barcoding was constructed. This study could provide basic data for identifying the original plants of Tibetan medicine Jieji Gabao， improving the quality standard of Tibetan genuine medicinal materials and studying the phylogeny of Gentianaceae plants.Keywords：Jieji Gabao;Tibetan medicine;Gentiana straminea;molecular pharmacognosy;DNA barcoding
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Published：2022-11-26
Special column on Identification of traditional Chinese medicine
- Abstract：Objective： To observe the clinical effects of modified Xiaochaihu Decoction in the treatment of cancer related insomnia （CRI） with Shaoyang syndrome.MethodsA total of 86 patients of CRI with Shaoyang syndrome were included and randomly divided into the treatment group and control group， 43 cases in each group. The patients in the treatment group were orally treated with modified Xiaochaihu Decoction and the patients in the control group were orally treated with estazolam tablet， with a course of 4 weeks. Before and after treatment， the score of Pittsburgh sleep quality index （PSQI）， the total score of traditional Chinese medical syndrome and the scores of three main symptoms including difficulty falling asleep， light sleep with easy awakening， night sleep with many dreams in the two groups were evaluated and compared. After treatment， the curative effects of traditional Chinese medical syndrome in the two groups were evaluated.ResultsIn the course of treatment， 3 patients in the treatment group were removed or dropped off and 3 patients in the control group dropped off， finally 40 patients in the treatment group and 40 patients in the control group were included in the statistical analysis. After treatment， the PSQI score， the total score of traditional Chinese medical syndrome and the scores of three main symptoms in the two groups were significantly decreased compared with those before treatment （P<0.05）， and the PSQI score， the total score of traditional Chinese medical syndrome and the symptom scores of light sleep with easy awakening and night sleep with many dreams in the treatment group were lower than those in the control group （P<0.05）. After treatment， the total effective rates of traditional Chinese medical syndrome was 87.5% in the treatment group and 70.0% in the control group， and the curative effect of traditional Chinese medical syndrome in the treatment group was significantly better than that in the control group （P<0.05）.ConclusionModified Xiaochaihu Decoction has better curative effects in the treatment of CRI with Shaoyang syndrome， and can improve the sleep quality and the traditional Chinese medical syndrome of the patients， which is worth further popularizing in the clinic.Keywords：cancer related insomnia;Shaoyang syndrome;Xiaochaihu Decoction;Pittsburgh sleep quality index
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Published：2022-11-26 - Abstract：Objective： To observe the clinical effect of Qingshu Decoction in the treatment of summer dermatitis with type of heat and dampness resistance.MethodsA total of 108 patients of summer dermatitis with type of heat and dampness resistance were included and randomly divided into the treatment group and control group， 54 cases in each group. The patients in the treatment group were treated with Qingshu Decoction orally combined with calamine lotion externally， and the patients in the control group were treated with cetirizine hydrochloride tablets orally combined with calamine lotion externally. The treatment course was 14 days. Before treatment and after 1 week and 2 weeks of treatment， the scores of traditional Chinese medical syndrome， eczema area and severity index （EASI） and pruritus were evaluated. After 2 weeks of treatment， the clinical efficacy and the traditional Chinese medical syndrome efficacy of the two groups were evaluated and compared.ResultsAfter 2 weeks of treatment， the total clinical effective rate was 100.00% in the treatment group and 77.78% in the control group， and the therapeutic effect of the treatment group was significantly better than that of the control group （P<0.01）； the total effective rate of traditional Chinese medical syndrome was 88.89% in the treatment group and 79.63% in the control group， and the curative effect on traditional Chinese medical syndrome in the treatment group was significantly better than that in the control group （P<0.01）. After 1 week of treatment， the traditional Chinese medical syndrome score and EASI score of the two groups were significantly decreased compared with those before treatment （P<0.05， P<0.01）， and the EASI score of the treatment group was significantly lower than that of the control group （P<0.01）； after 2 weeks of treatment， the scores of traditional Chinese medical syndrome， EASI and pruritus symptom in the two groups were significantly decreased compared with those before treatment （P<0.01）， and the above scores of the treatment group were significantly lower than those of the control group （P<0.01）.ConclusionQingshu Decoction combined with calamine lotion can significantly relieve the skin lesions， pruritus symptom and traditional Chinese medical syndrome in patients of summer dermatitis with type of heat and dampness resistance， which is an effective treatment regimen for summer dermatitis.Keywords：summer dermatitis;Qingshu Decoction;type of heat and dampness resistance;traditional Chinese medical therapy
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Published：2022-11-26 - Abstract：Objective： To compare the efficacy， safety and health economic indicators between intersphincteric drainage and simple incision drainage in the treatment of perianal abscess.MethodsA total of 90 patients with perianal abscess were included and randomly divided into the study group and the control group， 45 cases in each group. The patients in the study group were treated with intersphincter drainage， and the patients in the control group were treated with simple incision drainage. Follow-up for 3 months after surgery， the formation rate of anal fistula， recurrence rate of perianal abscess and wound healing time were compared between the two groups. After surgery， the scores of anal pain， wound secretion exudation， fever and the first urination were evaluated. Three months after surgery， the scores of anal function assessment scale （Wexner） and anal appearance in the two groups were evaluated. The hospitalization time and cost were compared between the two groups.Results①The recurrence rate of perianal abscess was 0% in the study group and 6.67% in the control group， and there was no statistically significant difference on the recurrence rate between the two groups （P>0.05）. The formation rate of anal fistula was 22.2% in the study group and 48.9% in the control group， and the formation rate of anal fistula in the study group was lower than that in the control group （P<0.01）. The wound healing time of the study group was significantly shorter than that of the control group （P<0.01）. ②On the 3rd and 7th days after surgery， there was statistically significant difference on the visual analogue scale （VAS） score of anal pain between the two groups （P<0.05， P<0.01）， and the anal pain condition of the study group was superior to the control group. On the 3rd day after surgery， there was statistically significant difference on the score of wound secretion exudation between the two groups （P<0.05）， and the wound secretion exudation condition of the study group was superior to the control group. After surgery， there was no statistically significant difference on the score of fever between the two groups （P>0.05）. There was statistically significant difference on the score of postoperative first urination between the two groups （P<0.05）， and the postoperative first urination condition of the study group was superior to the control group. ③Three months after surgery， there were no statistically significant differences on the Wexner score and the anal appearance score between the two groups （P>0.05）. ④The hospitalization time of the study group was significantly shorter than that of the control group （P<0.05）， and the hospitalization cost of the study group was significantly less than that of the control group （P<0.01）.ConclusionCompared with simple incision drainage， intersphincter drainage has better therapeutic effect and safety in the treatment of perianal abscess， and its postoperative complications is mild， the health economic benefits are better.Keywords：perianal abscess;intersphincter drainage;sphincter preservation;clinical efficacy
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Published：2022-11-26 - Abstract：ObjectivesBy assessing the characteristics of grip strength， gait speed， short physical performance and traditional Chinese medicine （TCM） constitution of the elderly living in Pudong community of Shanghai， we can understand the correlation between fall risk and TCM constitution of the elderly living in the community， and clarify the characteristics of easy fall constituion， which can provide reference for health intervention.MethodsThe subjects who lived in the community and were over 50 years old were selected to voluntarily sign the informed consent form. Indicators of grip strength， 6 m pace， short physical performance battery （SPPB）， and TCM physical questionnaire were observed. Fall risk of subjects of different genders and difference age groups was analyzed， and its correlation with grip strength， 6 m pace， short physical performance， and TCM constitution was analyzed.Results①A total of 403 subjects who signed informed consent form were included in this study， including 92 males and 311 females. The average grip strength of males was （36.12±7.11） kg， and the average grip strength of females was （22.48± 4.64） kg. The average 6m pace of males was （1.15±0.21） m/s， and the average 6m pace of females was （1.10±0.20） m/s. ②The average fall risk of males was （6.53±3.85） years， and the average fall risk of femals was （6.13±3.79） years. The male SPPB score was （10.85±1.28）， and the female SPPB score was （10.75±1.49）. There was no statistical difference between the two groups for fall risk and SPPB score. Among all the TCM constitutions， yang deficiency constitution showed the highest frequency， accounting for 28.98%， followed by balanced constitution （21.14%）， yin deficiency constitution， qi stagnation constitution， qi deficiency constitution， phlegm dampness constitution， blood stasis constitution， inherited special constitution， and damp heat constitution. Fall risk was positively correlated with age and five times of sitting-up time； and negatively correlated with grip strength， 6m pace， tandem standing score， and SPPB score. ③Fall risk was negatively correlated with balanced constitution and positively correlated with biased constitutions.ConclusionAge is an independent risk factor for the increased risk of falls in the elderly with normal community activities， and the elderly with a biased constitution have higher risk of falls.Keywords：fall risk;traditional Chinese medicine constitution;grip strength;gait speed;short physical performance
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Published：2022-11-26
Clinical Research
- Abstract：Objective： To explore the effect and mechanism of Jiangzhi Granule on nonalcoholic steatohepatitis （NASH） based on adipose tissue dysfunction.MethodsC57BL/6J mice were fed with high-fat and calorie diet plus high-fructose/glucose drinking water for 10 weeks to establish NASH mode， while 8 normal mice were randomly selected as the control group and given ordinary diet. After modeling， the model mice were randomly divided into model group， rosiglitazone group， low and high dose Jiangzhi Granule group （JZG-L and JZG-H group）， with 8 mice in each group. Mice in the control group were given ordinary diet， mice in the other groups were given high-fat diet， and mice in the treating groups were given corresponding drugs by gavage every day. After continuous intervention for 8 weeks， the body weight， liver weight and epididymis fat weight of mice were measured. The serum levels of alanine aminotransferase （ALT） and total cholesterol （TC） were measured by commercial kits. Histopathological changes of liver and adipose tissue were observed by HE staining. The number of macrophages and M1/M2 typing ratio in epididymal adipose tissue of mice were detected by flow cytometry. RT-qPCR was used to analyze the mRNA expression levels of inflammatory cytokines such as tumor necrosis factor （TNF）-α， interleukin （IL）-6， IL-10 and monocyte chemotactic protein 1 （MCP⁃1） in epididymal adipose tissue. The expression levels of lipid metabolism related genes including adiponectin （ADIPOQ）， glucose transporter 4 （GLUT4）， fatty acid binding protein 4 （FABP4） and phosphoenolpyruvate carboxykinase 1 （PCK1） were also analyzed.Results① Compared with the control group， the body weight， liver weight and epididymal fat weight of mice in the model group significantly increased （P<0.01）. Compared with the model group， the body weight of mice in the JZG-L and JZG-H group significantly decreased （P<0.05）， the liver weight of mice in the JZG-H group significantly decreased （P<0.05）， epididymal fat weight showed a downward trend； the serum levels of ALT and TC of mice in JZG-L and JZG-H groups significantly decreased （P<0.01）. ②In the model group， extensive hepatic steatosis was found in mice liver tissues with hepatic lobule inflammation and a lot of ballooning degeneration， which were improved by Jiangzhi Granule treatment， and the NAS scores were significantly decreased as well （P<0.01）. ③Compared with the model group， the size of adipocyte and the inflammatory infiltration in epididymal adipose tissue of mice in JZG-H group reduced. ④After intervention with Jiangzhi Granule， the number of macrophages and the proportion of M1/M2 macrophages in mice epididymal adipose tissues decreased （P<0.05）； the mRNA levels of pro-inflammatory cytokines IL-6， MCP-1 and TNF-α significantly decreased （P<0.05， P<0.01） and the mRNA level of anti-inflammatory cytokine IL-10 increased （P<0.05）； the mRNA levels of ADIPOQ and GLUT4 increased（P<0.05） and the mRNA expressions of FABP4 and PCK1 decreased （P<0.05）.ConclusionJiangzhi Granule can effectively improve NASH in mice， which may play a role in the treatment of NASH by alleviating the pathology and dysfunction of adipose tissue.Keywords：Jiangzhi Granule;nonalcoholic steatohepatitis;adipose tissue dysfunction;adipose-liver crosstalk
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Published：2022-11-26 - Abstract：Objective： To explore the mechanism of Shaoyao Gancao Decoction （SYGCD）in the treatment of ulcerative colitis（UC）based on network pharmacology， differential gene analysis， molecular docking technology and in vitro cell experiments.MethodsTraditional Chinese Medicine Systems Pharmacology Database and Analysis Platform（TCMSP）and literature retrieval were used to obtain the active ingredients and targets of SYGCD. GSE47908 microarray data were obtained from GEO database， and differential gene heatmaps and volcano plots were drawn. The molecular gene network map of SYGCD against UC was constructed by Cytoscape software， and the core target topology network was drawn by Bisogenet and CytoNCA. GO functional enrichment analysis and KEGG pathway enrichment analysis of differential genes were performed by R 3.6.3 software. Molecular docking was used to analyze the interaction between active ingredients and key targets. RAW264.7 macrophages were used to preliminarily verify the anti-inflammatory effect of SYGCD by MTT assay and RT-qPCR assay in vitro.Results①102 active ingredients of SYGCD for UC treatment were obtained， mainly including quercetin， kaempferol， isorhamnetin， etc. The key candidate genes such as peroxisome proliferator-activated receptor-γ （PPARγ） and inducible nitric oxide synthase （NOS2） were selected by topological network. Enrichment analysis showed that UC treatment was mainly related to interleukin （IL）-17 signaling pathway and tumor necrosis factor （TNF） signaling pathway， etc. ②Molecular docking results showed that the core components of SYGCD could bind to the key targets stably by hydrogen bonding. ③MTT assay results showed that SYGCD was almost not toxic to RAW264.7 cells. RT-qPCR results showed that SYGCD could reduce the mRNA expression levels of TNF-α， IL-1β and IL-6 cytokines in RAW264.7 cell inflammation model.ConclusionSYGCD has the characteristics of multi-component， multi-target and multi-pathway in treating UC， the mechanism of which may be that the active components of SYGCD， such as quercetin， kaempferol， formononetin， and isorhamnetin， act on the targets of PPARγ， NOS2， and IL-1β to regulate the signaling pathway of IL-17， TNF， and NF-κB to play a role in treating UC. SYGCD can exert anti-inflammatory effects by regulating pro-inflammatory cytokines TNF-α， IL-1β and IL-6.Keywords：Shaoyao Gancao Decoction;ulcerative colitis;network pharmacology;GEO chip;molecular docking;in vitro cell experiments
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Published：2022-11-26 - Abstract：Objective： To investigate the related mechanism of modified Wuzi Yanzong Pill on prevention and treatment of osteoporosis in apolipoprotein E knockout（ApoE-/-） mice.MethodsThe 8-week-old ApoE-/- mice were randomly divided into negative control group， model group， treatment group and positive control group， with 6 mice in each group. The mice in negative control group and model group were fed with normal diet. The mice in treatment group and positive control group were fed with high fat diet， supplemented with modified Wuzi Yanzong Pill and alendronate sodium by gavage respectively. After 24 weeks of continuous intervention， femurs of mice in each group were taken for micro computed tomography （Micro CT）， HE staining， Trap staining and immumohistochemical staining to observe the status of osteoporosis， the number of osteoclasts and the expression of retinoid X receptor （RXR） in each group.Results①Compared with the negative control group， femur Micro CT detection indexes of bone mineral density （BMD）， bone volume fraction （BV/TV）， trabecular thickness （Tb.Th） and trabecular number （Tb.N） in model group were significantly decreased （P<0.05）. Compared with the model group， BMD， BV/TV， Tb.Th and Tb.N in treatment group were significantly increased （P<0.05）. ②Compared with the negative control group， the osteoporosis area in the model group was significantly increased （P<0.01）. Compare with the model group， the area of osteoporosis in the treatment group and the positive control group was significantly decreased （P<0.01）. ③The numbers of osteoclasts in the model group were significantly higher than that in the negative control group （P<0.01）， while the number of osteoclasts in the treatment group and positive control group was significantly lower than that in the model group（P<0.01）. ④Compared with the negative control group， the expression of RXRα and RXRβ protein in the model group was significantly increased （P<0.01）； Compared with the model group， the expression of RXRα and RXRβ protein in the treatment group and positive control group was significantly decreased （P<0.01）.ConclusionModified Wuzi Yanzong Pill could inhibit the progression of femur osteoporosis in ApoE-/- mice， and the mechanism may be related to the inhibition of RXR expression and osteoclast proliferation.Keywords：modified Wuzi Yanzong Pill;osteoporosis;ApoE-/- mice;high fat diet;retinoid X receptor
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Published：2022-11-26 - Abstract：Methods48 female Wistar rats were randomly divided into control group， model group， diclofenac sodium group （6.75 mg·kg-1·d-1， i.g.）， low dose （247.5 mg·kg-1·d-1， i.g.）， medium-dose （742.5 mg·kg-1·d-1， i.g.） and high dose （2 227.5 mg·kg-1·d-1， i.g.） of Wang-Bi Capsule groups. Except for control group， rats in the other groups were given collagen Ⅱ to induce synovitis model. After the successful establishment of synovitis model， rats in diclofenac sodium group and each dose group of Wang-Bi capsule were treated with continous administration for 3 weeks， while rats in control and model group were given equal amount of sodium carboxymethyl cellulose solution. Metatarsal swelling degree and arthritis index of rats in each group were detected by volume measurement method and scoring method. The levels of serum TNF-α， IL-1β， IL-10 in rats were measured by enzyme-linked immunosorbent assay. And the histopathological changes of synovial membrane were detected by hematoxylin-eosin staining.ResultsCompared with the model group， metatarsal swelling and arthritis index scores of rats in diclofenac sodium group and low， medium and high dose of Wang-Bi Capsule groups were decreased to varying degrees， the levels of serum TNF-α， IL-1β were decreased significantly while the level of IL-10 was increased significantly， and inflammation was relieved to varying degrees（P<0.05，P<0.01，P<0.001）.ConclusionWang-Bi Capsule can alleviate synovial inflammation caused by collagen Ⅱ in rats， showing its certain therapeutic effect.ObjectiveTo investigate the therapeutic effect of Wang-Bi Capsule on collagen Ⅱ induced synovitis in rats.Keywords：Wang-Bi Capsule;synovitis;collagen Ⅱ
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Published：2022-11-26
Experiment Research
- Abstract：Objective： To evaluate the efficacy of Compound Danshen Dripping Pill on the major adverse cardiovascular events （MACE） and the improvement of ventricular remodeling in patients with acute myocardial infarction （AMI） after percutaneous coronary intervention （PCI） by Meta-analysis method.MethodsThe randomized controlled trials （RCT） about the effect of Compound Danshen Dropping Pill on MACE and ventricular remodeling improvement in patients with AMI after PCI were searched by computer. RevMan 5.4 software was used for Meta-analysis and bias risk evaluation， and the quality of evidence was evaluated according to GRADE standard.ResultsA total of 12 literatures were included， including 1 390 patients. The results of Meta-analysis showed that， Compound Danshen Dripping Pill could reduce the total incidence of MACE in patients with AMI after PCI （RR=0.43， 95%CI［0.33， 0.55］， P<0.000 01）； in terms of improving ventricular remodeling， Compound Danshen Dripping Pill could increase the left ventricular ejection fraction （LVEF， MD=4.77， 95%CI［4.04，5.50］， P<0.000 01）， and reduce the left ventricular end-diastolic dimension （LVEDD， MD=-3.64， 95%CI［-5.42，-1.86］， P<0.000 1） and left ventricular end-systolic diameter （LVESD， MD=-3.24， 95%CI［-4.88，-1.59］， P=0.000 1） in patients with AMI after PCI； there was no statistically significant difference on the incidence of adverse reactions between the two groups （RR=0.73， 95%CI［0.34， 1.68］， P=0.48）. The results of GRADE evidence quality evaluation showed that， MACE， LVEF and LVEDD were the moderate quality evidence， and the LVESD and the incidence of adverse reactions were the low quality evidence.ConclusionCompound Danshen Dripping Pill has obvious efficacy on the MACE in patients with AMI after PCI， can effectively improve the cardiac function and ventricular remodeling， with no adverse reactions. Since the GRADE evidence quality evaluation results are of medium or low quality， the above conclusions need to be verified by more high quality studies.Keywords：acute myocardial infarction;percutaneous coronary intervention;Compound Danshen Dripping Pill;major adverse cardiovascular events;ventricular remodeling;Meta-analysis;GRADE evaluation
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Published：2022-11-26
Theoretical Research
- Abstract：Coronavirus disease 2019 （COVID-19） is an acute infectious disease caused by severe acute respiratory disease coronavirus 2 （SARS-CoV-2）， which may affect multiple organs and systems throughout the body in addition to lung damage. Among them， one of the notable pathological features is coagulopathy， which is commonly found in patients with severe and critical COVID-19， mainly characterized by the significant increase in D-dimer and fibrinogen. Coagulopathy and the formation of thrombosis could also lead to a significant reduction in the number of platelets and other consequences. Clinical studies have shown that coagulopathy is closely related to the severity and mortality rates of COVID-19 patients. In this review， coagulopathy and its possible mechanisms as well as treatment strategies in patients with COVID-19 were reviewed to provide reference for the treatment of COVID-19 and other similar inflammatory diseases.Keywords：COVID-19;coagulopathy;D-dimer;thrombus;platelet
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Published：2022-11-26
Review
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