The optimized granulation parameters were as follows： initial material temperature （38±1）℃， air inlet temperature 70℃， concentrated liquid density was 1.24~1.26 g/cm3 （25 ℃）. The drug loading of the obtained granules was 72%， which was about 50% higher than that before optimization. The contents of calycosin-7-O-β-D-glucoside and rosmarinic acid in the obtained preparation were 0.298 3 mg/g and 0.989 5 mg/g， respectively. Meanwhile， its moisture， particle size and solubility and other inspection items all met the requirements of Chinese Pharmacopoeia.