Mechanism of electroacupuncture inhibiting microglia activation mediating chronic pain analgesia

LIANG Jiayi; GU Yiming; WANG Gongming; MENG Xiang; XIA Yong; WANG Ke; JU Ziyong

doi:10.16306/j.1008-861x.2024.02.003

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Mechanism of electroacupuncture inhibiting microglia activation mediating chronic pain analgesia

Special column on acupuncture | 更新时间：2024-04-15

- Mechanism of electroacupuncture inhibiting microglia activation mediating chronic pain analgesia
- Academic Journal of Shanghai University of Traditional Chinese Medicine Vol. 38, Issue 2, Pages: 14-20(2024)
- 作者机构：
  
  1.上海中医药大学针灸推拿学院（上海　201203）
  2.上海中医药大学附属岳阳中西医结合医院（上海　200437）
- 作者简介：
- 基金信息：
- DOI：10.16306/j.1008-861x.2024.02.003
  CLC：
- Published：25 March 2024，
  
  Received：27 September 2023，
  
  Revised：16 November 2023，
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梁嘉仪,顾意鸣,王功命等.电针抑制小胶质细胞活化介导慢性疼痛镇痛的作用机制[J].上海中医药大学学报,2024,38(02):14-20.

LIANG Jiayi,GU Yiming,WANG Gongming,et al.Mechanism of electroacupuncture inhibiting microglia activation mediating chronic pain analgesia[J].Academic Journal of Shanghai University of Traditional Chinese Medicine,2024,38(02):14-20.
梁嘉仪,顾意鸣,王功命等.电针抑制小胶质细胞活化介导慢性疼痛镇痛的作用机制[J].上海中医药大学学报,2024,38(02):14-20. DOI： 10.16306/j.1008-861x.2024.02.003.

LIANG Jiayi,GU Yiming,WANG Gongming,et al.Mechanism of electroacupuncture inhibiting microglia activation mediating chronic pain analgesia[J].Academic Journal of Shanghai University of Traditional Chinese Medicine,2024,38(02):14-20. DOI： 10.16306/j.1008-861x.2024.02.003.

摘要

慢性疼痛是目前世界上最难治愈的疾病之一，过往认为其产生仅与神经元的可塑性有关，而现在越来越关注到非神经元细胞特别是小胶质细胞的重要参与作用。电针因其安全有效性已逐渐成为慢性疼痛的一种替代疗法，其镇痛作用可通过抑制小胶质细胞的过度活化实现。以电针对慢性疼痛中小胶质细胞活化的调控作用为基点，探讨电针的镇痛作用机制，以期为临床电针镇痛的有效性提供依据。

Abstract

Chronic pain is one of the most difficult diseases to cure in the world. In the past， it was thought that the appearance of chronic pain was only related to the plasticity of neurons， but now more and more attention has been paid to the important involvement of non-neuronal cells， especially microglia. Electroacupuncture has gradually become an alternative therapy for chronic pain due to its safety and effectiveness， and its analgesic effect can be achieved by inhibiting the overactivation of microglia. Based on the regulation effect of electroacupuncture on the microglia activation in chronic pain， the analgesic mechanism of electroacupuncture is discussed， in order to provide a basis for the effectiveness of clinical electroacupuncture analgesia.

关键词

慢性疼痛电针镇痛小胶质细胞神经胶质反应

Keywords

chronic painelectroacupunctureanalgesiamicrogliaglial reaction

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