Research progress on intervention of active components of traditional Chinese medicine on epithelial⁃mesenchymal transition of cervical cancer

QI Ding; LI Hongmei; LIANG Mingge; ZHANG Mingshu; MEN Hao; AI Wenxia; HAN Buwei; LIU Li

doi:10.16306/j.1008-861x.2023.04.013

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Research progress on intervention of active components of traditional Chinese medicine on epithelial⁃mesenchymal transition of cervical cancer

Review | 更新时间：2023-08-04

- Research progress on intervention of active components of traditional Chinese medicine on epithelial⁃mesenchymal transition of cervical cancer
- Academic Journal of Shanghai University of Traditional Chinese Medicine Vol. 37, Issue 4, Pages: 102-108(2023)
- 作者机构：
  
  1.黑龙江中医药大学（黑龙江　哈尔滨　150036）
  2.黑龙江中医药大学附属第二医院（黑龙江　哈尔滨　150000）
  3.黑龙江中医药大学附属第一医院（黑龙江　哈尔滨　150036）
- 作者简介：
- 基金信息：
- DOI：10.16306/j.1008-861x.2023.04.013
  CLC：
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亓丁,李红梅,梁铭阁等.中药活性成分对宫颈癌上皮间充质转化干预作用的研究进展[J].上海中医药大学学报,2023,37(04):102-108.

QI Ding,LI Hongmei,LIANG Mingge,et al.Research progress on intervention of active components of traditional Chinese medicine on epithelial⁃mesenchymal transition of cervical cancer[J].Academic Journal of Shanghai University of Traditional Chinese Medicine,2023,37(04):102-108.
亓丁,李红梅,梁铭阁等.中药活性成分对宫颈癌上皮间充质转化干预作用的研究进展[J].上海中医药大学学报,2023,37(04):102-108. DOI： 10.16306/j.1008-861x.2023.04.013.

QI Ding,LI Hongmei,LIANG Mingge,et al.Research progress on intervention of active components of traditional Chinese medicine on epithelial⁃mesenchymal transition of cervical cancer[J].Academic Journal of Shanghai University of Traditional Chinese Medicine,2023,37(04):102-108. DOI： 10.16306/j.1008-861x.2023.04.013.

摘要

宫颈癌（CC）为女性常见恶性肿瘤，上皮间充质转化（EMT）与CC的发生、发展和转移、播散密切相关，抑制EMT过程对降低CC患者的复发率及病死率具有重要意义。通过总结不同种类的中药活性成分对CC EMT的影响，阐明中药活性成分对CC EMT的逆转作用，并发现清热药、补虚药、活血化瘀药及补益肝肾、通调下焦法在CC EMT干预中存在潜在治疗作用，后续应进一步通过相关实验予以验证，以对中药防治CC EMT的精准研究提供思路，并对防治CC转移及丰富现存治疗手段提供新的参考。

Abstract

Cervical cancer （CC） is a common female malignant tumor. Epithelial-mesenchymal transition （EMT） is closely related to the occurrence， development， metastasis and dissemination of CC， and inhibiting EMT course is of great significance in reducing the recurrence and mortality rates of CC. By summing up the effect of different kinds of active components of traditional Chinese medicine on EMT of CC， this paper clarifies the reverse effect of active components of traditional Chinese medicine on EMT of CC， and finds that the clearing heat Chinese medicine， tonifying deficiency Chinese medicine， promoting blood circulation and removing blood stasis Chinese medicine， and the methods of tonifying liver and kidney， and dredging and regulating down Jiao has potential therapeutic effects in the intervention of EMT of CC， which should be further verified by relevant experiments， in order to provide a new idea for the precise study of Chinese medicine in the prevention and treatment of EMT of CC， and to provide a new reference for the prevention and treatment of CC metastasis and the enrichment of existing treatment methods.

关键词

宫颈癌中药活性成分上皮间充质转化转化生长因子-β1综述

Keywords

cervical canceractive ingredients of traditional Chinese medicineepithelial-mesenchymal transitiontransforming growth factor-β1review

references

TORNESELLO M L， BUONAGURO L， GIORGI-ROSSI P， et al. Viral and cellular biomarkers in the diagnosis of cervical intraepithelial neoplasia and cancer［J］. Biomed Res Int， 2013， 2013： 519619.

NAGELHOUT G， EBISCH R M， VAN DER HEL O， et al. Is smoking an independent risk factor for developing cervical intra-epithelial neoplasia and cervical cancer？ A systematic review and meta-analysis［J］. Expert Rev Anticancer Ther， 2021， 21（7）： 781-794.

LOOPIK D L， INTHOUT J， MELCHERS W J G， et al. Oral contraceptive and intrauterine device use and the risk of cervical intraepithelial neoplasia grade Ⅲ or worse： a population-based study［J］. Eur J Cancer， 2020， 124： 102-109.

BARILLARI G， BEI R， MANZARI V， et al. Infection by High-Risk Human Papillomaviruses， Epithelial-to-Mesenchymal Transition and Squamous Pre-Malignant or Malignant Lesions of the Uterine Cervix： A Series of Chained Events？［J］. Int J Mol Sci， 2021， 22（24）： 13543.

SHIBUE T， WEINBERG R A. EMT， CSCs， and drug resistance： the mechanistic link and clinical implications［J］. Nat Rev Clin Oncol， 2017， 14（10）： 611-629.

LI Y J， LEI Y H， YAO N， et al. Autophagy and multidrug resistance in cancer［J］. Chin J Cancer， 2017， 36（1）： 52.

赵延华. 周仲瑛辨治宫颈癌与卵巢癌学术传承及创新研究［D］. 南京：南京中医药大学， 2019.

ZHAO Y H. Academic inheritance and innovation of Zhou Zhongying’s syndrome differentiation and treatment of cervical cancer and ovarian cancer ［D］. Nanjing： Nanjing University of Traditional Chinese Medicine， 2019.

HONG M， TAN H Y， LI S， et al. Cancer Stem Cells： The Potential Targets of Chinese Medicines and Their Active Compounds［J］. Int J Mol Sci， 2016， 17（6）： 893.

DE STREEL G， LUCAS S. Targeting immunosuppression by TGF-β1 for cancer immunotherapy［J］. Biochem Pharmacol， 2021， 192： 114697.

KIM K K， SHEPPARD D， CHAPMAN H A. TGF-β1 Signaling and Tissue Fibrosis［J］. Cold Spring Harb Perspect Biol， 2018， 10（4）： a022293.

LAMOUILLE S， XU J， DERYNCK R. Molecular mechanisms of epithelial-mesenchymal transition［J］. Nat Rev Mol Cell Biol， 2014，15（3）： 178-196.

LIAO T T， YANG M H. Revisiting epithelial-mesenchymal transition in cancer metastasis： the connection between epithelial plasticity and stemness［J］. Mol Oncol， 2017， 11（7）： 792-804.

LI G， DING K， QIAO Y， et al. Flavonoids Regulate Inflammation and Oxidative Stress in Cancer［J］. Molecules， 2020， 25（23）： 5628.

XIA J， CHEN J， ZHANG Z， et al. A map describing the association between effective components of traditional Chinese medicine and signaling pathways in cancer cells in vitro and in vivo［J］. Drug Discov Ther， 2014， 8（4）： 139-153.

AEDO-AGUILERA V， CARRILLO-BELTRÁN D， CALAF G M， et al. Curcumin decreases epithelial-mesenchymal transition by a Pirin-dependent mechanism in cervical cancer cells［J］. Oncol Rep， 2019， 42（5）： 2139-2148.

DONG W， CHEN A， CHAO X， et al. Chrysin Inhibits Proinflammatory Factor-Induced EMT Phenotype and Cancer Stem Cell-Like Features in HeLa Cells by Blocking the NF-κB/Twist Axis［J］. Cell Physiol Biochem， 2019， 52（5）： 1236-1250.

WANG J， CHEN H， HU Z， et al. Hesperetin regulates transforming growth factor-β1/Smads pathway to suppress epithelial-mesenchymal transition-mediated invasion and migration in cervical cancer cell［J］. Anticancer Drugs， 2021， 32（9）： 930-938.

IMRAN M， RAUF A， SHAH Z A， et al. Chemo-preventive and therapeutic effect of the dietary flavonoid kaempferol： A comprehensive review［J］. Phytother Res， 2019， 33（2）： 263-275.

IMRAN M， SALEHI B， SHARIFI-RAD J， et al. Kaempferol： A Key Emphasis to Its Anticancer Potential［J］. Molecules， 2019， 24（12）： 2277.

DE SOUZA V R， BRUM M C M， GUIMARÃES I D S， et al. Amazon Fruits Inhibit Growth and Promote Pro-apoptotic Effects on Human Ovarian Carcinoma Cell Lines［J］. Biomolecules， 2019， 9（11）：707.

CHEN X， XU P， ZHANG H， et al. EGFR and ERK activation resists flavonoid quercetin-induced anticancer activities in human cervical cancer cells in vitro［J］. Oncol Lett， 2021， 22（5）： 754.

LIN T H， HSU W H， TSAI P H， et al. Dietary flavonoids， luteolin and quercetin， inhibit invasion of cervical cancer by reduction of UBE2S through epithelial-mesenchymal transition signaling［J］. Food Funct， 2017， 8（4）： 1558-1568.

LEI H， SHI J， TENG Y， et al. Baicalein modulates the radiosensitivity of cervical cancer cells in vitro via miR-183 and the JAK2/STAT3 signaling pathway［J］. Adv Clin Exp Med， 2021， 30（7）： 727-736.

CHEN Y H， WU J X， YANG S F， et al. Anticancer Effects and Molecular Mechanisms of Apigenin in Cervical Cancer Cells［J］. Cancers （Basel）， 2022， 14（7）： 1824.

THACKER P C， KARUNAGARAN D. Curcumin and emodin down-regulate TGF-β signaling pathway in human cervical cancer cells［J］. PLoS One， 2015， 10（3）： e0120045.

CHEN L， LIANG J F. Metabolic monosaccharides altered cell responses to anticancer drugs［J］. Eur J Pharm Biopharm， 2012， 81（2）： 339-345.

JIN H， SONG C， ZHAO Z， et al. Ganoderma Lucidum Polysaccharide， an Extract from Ganoderma Lucidum， Exerts Suppressive Effect on Cervical Cancer Cell Malignancy through Mitigating Epithelial-Mesenchymal and JAK/STAT5 Signaling Pathway［J］. Pharmacology， 2020， 105（7-8）： 461-470.

ZHANG L， ZHOU J， QIN X， et al. Astragaloside Ⅳ inhibits the invasion and metastasis of SiHa cervical cancer cells via the TGF-β1-mediated PI3K and MAPK pathways［J］. Oncol Rep， 2019， 41（5）： 2975-2986.

SHI X， YANG J， WEI G. Ginsenoside 20（S）-Rh2 exerts anti-cancer activity through the Akt/GSK3β signaling pathway in human cervical cancer cells［J］. Mol Med Rep， 2018， 17（3）： 4811-4816.

ZOU Y， SAREM M， XIANG S， et al. Autophagy inhibition enhances Matrine derivative MASM induced apoptosis in cancer cells via a mechanism involving reactive oxygen species-mediated PI3K/Akt/mTOR and Erk/p38 signaling［J］. BMC Cancer， 2019， 19（1）： 949.

CHU S C， YU C C， HSU L S， et al. Berberine reverses epithelial-to-mesenchymal transition and inhibits metastasis and tumor-induced angiogenesis in human cervical cancer cells［J］. Mol Pharmacol， 2014， 86（6）： 609-623.

REN H， HE G， LU Z， et al. Arecoline induces epithelial-mesenchymal transformation and promotes metastasis of oral cancer by SAA1 expression［J］. Cancer Sci， 2021， 112（6）： 2173-2184.

PIBOONPRAI K， KHUMKHRONG P， KHONGKOW M， et al. Anticancer activity of arborinine from Glycosmis parva leaf extract in human cervical cancer cells［J］. Biochem Biophys Res Commun， 2018， 500（4）： 866-872.

王明明，顾浦中，王晓曼，等. 蒽醌类天然化合物及肿瘤治疗研究进展［J］. 安徽化工， 2019， 45（2）： 4-9.

WANG M M， GU P Z， WANG X M， et al. Progress in anthraquinone natural compounds and cancer therapy［J］. Anhui Chemical Industry， 2019， 45（2）： 4-9.

TANG Q， LIU L， ZHANG H， et al. Regulations of miR-183-5p and Snail-Mediated Shikonin-Reduced Epithelial-Mesenchymal Transition in Cervical Cancer Cells［J］. Drug Des Devel Ther， 2020， 14： 577-589.

BAI L， MA Y， WANG X， et al. Polydatin Inhibits Cell Viability， Migration， and Invasion Through Suppressing the c-Myc Expression in Human Cervical Cancer［J］. Front Cell Dev Biol， 2021， 9： 587218.

SUN X， XU Q， ZENG L， et al. Resveratrol suppresses the growth and metastatic potential of cervical cancer by inhibiting STAT3Tyr705 phosphorylation［J］. Cancer Med， 2020， 9（22）： 8685-8700.

HSIEH Y S， CHU S C， HUANG S C， et al. Gossypol Reduces Metastasis and Epithelial-Mesenchymal Transition by Targeting Protease in Human Cervical Cancer［J］. Am J Chin Med， 2021， 49（1）： 181-198.

PANJI M， BEHMARD V， ZARE Z， et al. Suppressing effects of green tea extract and Epigallocatechin-3-gallate （EGCG） on TGF-β-induced Epithelial-to-mesenchymal transition via ROS/Smad signaling in human cervical cancer cells［J］. Gene， 2021， 794： 145774.

YANG A， LI M Y， ZHANG Z H， et al. Erianin regulates programmed cell death ligand 1 expression and enhances cytotoxic T lymphocyte activity［J］. J Ethnopharmacol， 2021， 273： 113598.

LIN Z， LIN Y， SHEN J， et al. Flavonoids in Ageratum conyzoides L. Exert Potent Antitumor Effects on Human Cervical Adenocarcinoma HeLa Cells In Vitro and In Vivo［J］. Biomed Res Int， 2020， 2020： 2696350.

HSIAO Y H， HSIEH M J， YANG S F， et al. Phloretin suppresses metastasis by targeting protease and inhibits cancer stemness and angiogenesis in human cervical cancer cells［J］. Phytomedicine， 2019， 62：152964.

WANG L， GUO H， YANG L， et al. Morusin inhibits human cervical cancer stem cell growth and migration through attenuation of NF-κB activity and apoptosis induction［J］. Mol Cell Biochem， 2013， 379（1-2）： 7-18.

NAYIM P， MBAVENG A T， SANJUKTA M， et al. CD24 gene inhibition and TIMP-4 gene upregulation by Imperata cylindrica’s root extract prevents metastasis of CaSki cells via inhibiting PI3K/Akt/snail signaling pathway and blocking EMT［J］. J Ethnoph-armacol， 2021， 275： 114111.

LEE M Y， SHEN M R. Epithelial-mesenchymal transition in cervical carcinoma［J］. Am J Transl Res， 2012， 4（1）： 1-13.

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