Comparison of effects of external application of Sihuang Powder with different formulas in treatment of infusion phlebitis in mice
- Academic Journal of Shanghai University of Traditional Chinese Medicine Vol. 37, Issue 1, Pages: 70-74(2023)
- 作者机构：
1.广州中医药大学深圳医院（福田）药学部（广东 深圳 518000）
2.山西省汾阳医院健康体检中心（山西 吕梁 032200）
- 作者简介：
- 基金信息：
DOI：10.16306/j.1008-861x.2023.01.010
CLC：
扫 描 看 全 文
肖秋元,雷雨禾,陈蕾等.不同组方的四黄散外用治疗小鼠输液性静脉炎的作用比较[J].上海中医药大学学报,2023,37(01):70-74.
XIAO Qiuyuan,LEI Yuhe,CHEN Lei,et al.Comparison of effects of external application of Sihuang Powder with different formulas in treatment of infusion phlebitis in mice[J].Academic Journal of Shanghai University of Traditional Chinese Medicine,2023,37(01):70-74.
肖秋元,雷雨禾,陈蕾等.不同组方的四黄散外用治疗小鼠输液性静脉炎的作用比较[J].上海中医药大学学报,2023,37(01):70-74. DOI： 10.16306/j.1008-861x.2023.01.010.
XIAO Qiuyuan,LEI Yuhe,CHEN Lei,et al.Comparison of effects of external application of Sihuang Powder with different formulas in treatment of infusion phlebitis in mice[J].Academic Journal of Shanghai University of Traditional Chinese Medicine,2023,37(01):70-74. DOI： 10.16306/j.1008-861x.2023.01.010.
摘要
目的,2,观察不同组方四黄散软膏外用对氟尿嘧啶相关性静脉炎小鼠的作用效果，优选出治疗静脉炎的最佳组方。,方法,2,制备不同组方的四黄散A、B、C、D软膏，将49只小鼠随机分成7组：空白组、模型组、阳性对照组及四黄散A、B、C、D软膏组。除空白组外，其余6组均连续3 d尾静脉注射氟尿嘧啶建立静脉炎模型，四黄散各软膏组分别外涂四黄散A、B、C、D软膏，阳性对照组外涂多磺酸粘多糖乳膏，空白组和模型组外涂空白赋形剂，观察各组小鼠静脉炎炎症程度、鼠尾肿胀度、静脉血炎性因子水平和鼠尾病理形态学变化。,结果,2,与空白组比较，模型组静脉炎分级、鼠尾肿胀度、静脉血炎性因子水平均升高（,P,<,0.05，,P,<,0.001），提示造模成功；四黄散各软膏组外涂5 d后，与治疗前比较，静脉炎分级、鼠尾肿胀度均降低（,P,<,0.05，,P,<,0.001），与模型组比较， CRP、IL-6和TNF-α水平均降低（,P,<,0.001）；与阳性对照组比较，四黄散C组治疗后，CRP和IL-6的水平降低（,P,<,0.05，,P,<,0.001）；病理切片形态学观察显示四黄散各软膏组均能降低静脉炎炎症程度。,结论,2,不同组方四黄散外用均能有效减轻氟尿嘧啶静脉注射导致的小鼠静脉炎，其中以四黄散组方C效果最优。
Abstract
Objective： To observe the therapeutic effects of different formulas of Sihuang Powder Ointment topically applied on mice with fluorouracil-associated phlebitis， and to select the optimal formula for the treatment of phlebitis.,Methods,2,Different formulas of Sihuang Powder Ointment A， B， C， D were prepared. Forty-nine mice were randomly divided into 7 groups： blank group， model group， positive control group and Sihuang Powder Ointment A， B， C， D groups. Except for the blank group， the mice in other 6 groups were injected with fluorouracil through tail vein for 3 consecutive days to establish phlebitis model. The Sihuang Powder Ointment groups were treated topically with Sihuang Powder Ointment A， B， C， and D correspondingly， the positive control group was treated topically with mucopolysaccharide polysulfate cream， and the blank and model groups were treated topically with blank excipient. The degree of phlebitis， the swelling degree of rat tail， the levels of inflammatory factors in venous blood， and the rat tail pathomorphological changes were observed in each group.,Results,2,Compared with the blank group， the grade of phlebitis， swelling degree of tail， and levels of inflammatory factors in venous blood in the model group were increased （,P,<,0.05， ,P,<,0.001）， indicating successful molding. After external treatment with Sihuang Powder Ointment A， B， C， D for 5 d correspondingly， the grade of phlebitis and swelling degree of tail in each Sihuang Powder Ointment group were decreased compared with those before treatment （,P,<,0.05， ,P,<,0.001）， the levels of CRP， IL-6 and TNF-α were decreased compared with the model group （,P,<,0.001）. The levels of CRP and IL-6 were decreased in Sihuang Powder C group after treatment compared with the positive control group （,P,<,0.05， ,P,<,0.001）. The degree of phlebitis inflammation in each Sihuang Powder Ointment group was reduced based on morphological observation of pathological sections.,Conclusion,2,External application of different formulas of Sihuang Powder can effectively reduce the phlebitis in mice induced by intravenous injection of fluorouracil， among which Sihuang Powder C has the best effect.
关键词
四黄散静脉炎氟尿嘧啶
Keywords
Sihuang Powderphlebitisfluorouracil
references
WEBSTER J， MCGRAIL M， MARSH N， et al. Postinfusion Phlebitis： Incidence and Risk Factors［J］. Nurs Res Pract， 2015： 691934. doi： 10.1155/2015/691934http://dx.doi.org/10.1155/2015/691934.
郭永福，张莉，刘汉斌，等.马铃薯喷雾剂对化疗性静脉炎小鼠的抗炎消肿作用［J］. 西部中医药，2020， 33（1）： 29-32.
GUO Y F， ZHANG L， LIU H B， et al. Anti inflammatory and detumescent effects of potato spray on chemotherapeutic phlebitis mice ［J］. Western Journal of Traditional Chinese Medicine， 2020，33 （1）： 29-32.
庞雪，刘明，孙庆，等.基于中医传承辅助平台的治疗血栓性浅静脉炎方剂组方规律分析［J］. 中药新药与临床药理，2019， 30（3）： 375-378.
PANG X， LIU M， SUN Q， et al. Analysis on the regularity of prescriptions for treating thrombophlebitis based on the auxiliary platform of traditional Chinese medicine inheritance ［J］. Traditional Chinese Drug Research and Clinical Pharmacology， 2019， 30（3）： 375-378.
付常庚，樊炜静，陈泽吉，等.中医外治法在血栓性浅静脉炎防治中的应用［J］.现代中西医结合杂志，2019， 28（35）： 3977-3981.
FU C G， FAN W J， CHEN Z J， et al. Application of external treatment of traditional Chinese medicine in the prevention and treatment of thrombophlebitis［J］. Modern Journal of Integrated Traditional and Western Medicine， 2019， 28（35）： 3977-3981.
危椠罡. 四黄散预防机械性静脉炎有效贴敷时间的临床观察［J］. 中国卫生标准管理，2017， 8（23）：180-182.
WEI J G. Clinical observation on the effective application time of Sihuang Powder to prevent mechanical phlebitis［J］. China Health Standard Management， 2017， 8（23）： 180-182.
宋丹，张黎芳，蒋元品，等.古医籍四黄散方药记载及现代临床应用概况［J］.国医论坛，2016， 31（2）： 52-53.
SONG D， ZHANG L F， JIANG Y P， et al. Records of Sihuang Powder in Ancient Medical Books and Overview of Modern Clinical Application［J］. Forum on Traditional Chinese Medicine， 2016， 31（2）： 52-53.
张蕻，泰刚，闫磊，等.化疗性静脉炎小鼠模型的建立［J］.实验动物科学，2010， 27（5）： 5-8.
ZHANG H， TAI G， YAN L， et al. Establishment of a mouse model of chemotherapeutic phlebitis［J］. Laboratory Animal Science， 2010， 27 （5）： 5-8.
胡杏平，林杏，钟滢，等.四黄水蜜与喜辽妥预防静脉滴注七叶皂苷钠所致静脉炎的效果对比［J］.广州中医药大学学报，2018， 35（3）： 419-422.
HU X P， LIN X， ZONG Y， et al. Comparison of Sihuang Shuimi and Xiliaotou in preventing phlebitis caused by intravenous infusion of sodium aescinat ［J］. Journal of Guangzhou University of Traditional Chinese Medicine， 2018， 35（3）： 419-422.
邱敏，李晓清，邹文娟，等.护脉散不同给药方式对长春瑞滨致静脉炎小鼠疗效观察［J］.世界中医药，2017， 12（10）： 2434-2437.
QIU M， LI X Q， ZOU W J， et al. Observation on the effect of different administration methods of Humei Powder on mice with phlebitis caused by Changchun Ruibin ［J］. World Chinese Medicine， 2017， 12（10）： 2434-2437.
李建鹏，王志彬，王壮壮，等.舒脉活化丸结合地奥司明对血栓性浅静脉炎临床疗效、血清炎症因子水平影响研究［J］.中华中医药学刊，2021， 39（11）： 221-224.
LI J P， WANG Z B， WANG Z Z， et al. Study on the clinical efficacy of Shumai Activating Pill combined with Diosmin on thrombophlebitis and the level of serum inflammatory factors ［J］. Chinese Archives of Traditional Chinese Medicine， 2021， 39 （11）： 221-224.
童翠玲，周红，耿敬.化学性静脉炎动物模型观察指标的研究现状［J］.护理学杂志，2019， 34（6）： 110-113.
TONG C L， ZHOU H， GENG J. Research status of observation indicators of chemical phlebitis animal models ［J］. Journal of Nursing Science， 2019， 34 （6）： 110-113.
0
Views
184
下载量
0
CSCD
0
CNKI被引量
- L-PDFDownload
- BibTeXDownload
- EndnoteDownload
- RefMan Download
- NoteExpressDownload
- NoteFirstDownload
Publicity Resources
Related Articles
Related Author
Related Institution
- Technical support is provided by Beijing Founder electronics co., LTD 京ICP备09064830号-19
京公网安备11010802024621 - It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
- Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.
- Total Visits：10154 Visits Today：17