WANG Zhixin,LU Hao,YAO Zhen,et al.Research progress on type 2 diabetes mellitus and related complications based on metabonomics[J].Academic Journal of Shanghai University of Traditional Chinese Medicine,2022,36(S1):296-300.
WANG Zhixin,LU Hao,YAO Zhen,et al.Research progress on type 2 diabetes mellitus and related complications based on metabonomics[J].Academic Journal of Shanghai University of Traditional Chinese Medicine,2022,36(S1):296-300. DOI: 10.16306/j.1008-861x.2022.S1.060.
Research progress on type 2 diabetes mellitus and related complications based on metabonomics
This paper reviews the research progress of metabonomics on type 2 diabetes mellitus and its associated complications, and analyzes the role of metabonomics in diabetic nephropathy, diabetic retinopathy, diabetic neuropathy and diabetic vasculopathy. It is believed that traditional Chinese medicine has unique advantages in the treatment of diabetes and the delaying the occurrence and development of complications. And through metabolomics, it has realized the early diagnosis of diabetes and related complications, which provides a possibility for delaying the occurrence and development of complications.
关键词
代谢组学2型糖尿病糖尿病并发症中医药疗法
Keywords
metabolomicstype 2 diabetes diabeticcomplicationstraditional Chinese medicine therapy
NICHOLSON J K, LINDON J C, HOLMES E. 'Metabonomics': understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data[J]. Xenobiotica, 1999, 29(11): 1181-1189.
FALL T, SALIHOVIC S, BRANDMAIER S, et al. Non-targeted metabolomics combined with genetic analyses identifies bile acid synthesis and phospholipid metabolism as being associated with incident type 2 diabetes[J]. Diabetologia, 2016, 59(10): 2114-2124.
FLORES-GUERRERO J L, OSTÉ M C J, KIENEKER L M, et al. Plasma branched-chain Amino Acids and risk of incident type 2 diabetes: results from the PREVEND prospective cohort study[J]. J Clin Med, 2018, 7(12): 513.
LIBERT D M, NOWACKI A S, NATOWICZ M R. Metabolomic analysis of obesity, metabolic syndrome, and type 2 diabetes: amino acid and acylcarnitine levels change along a spectrum of metabolic wellness[J]. Peerj, 2018, 6: e5410.
ARA B , GMB E , MS B, et al. 1H NMR based serum metabolic profiling reveals differentiating biomarkers in patients with diabetes and diabetes-related complication-Science Direct[J]. Diabetes & Metabolic Syndrome: Clinical Research & Reviews, 2019, 13(1): 290-298.
DU Y, XU B J, DENG X, et al. Predictive metabolic signatures for the occurrence and development of diabetic nephropathy and the intervention of ginkgo biloba leaves extract based on gas or liquid chromatography with mass spectrometry[J]. J Pharm Biomed Anal, 2019(166): 30-39.
DAI X, SU S, CAI H, et al. Protective effects of total glycoside from rehmannia glutinosa leaves on diabetic nephropathy rats via regulating the metabolic profiling and modulating the TGF-β1 and Wnt/β-Catenin signaling pathway.front pharmacol[J]. Front Pharmacol, 2018(9): 1012.
ZIYADEH F N, SIMMONS D A, SNIPES E R, et al. Effect of myo-inositol on cell proliferation and collagen transcription and secretion in tubule cells cultured in elevated glucose[J]. J Am Soc Nephrol, 1991, 1(11): 1220-1229
YOUL R S , SUNG J E , MIN P H, et al. Plasma glutamine and glutamic acid are potential biomarkers for predicting diabetic retinopathy[J]. Metabolomics, 2018, 14(7): 89.
ROJAS D R, KUNER R, AGARWAL N. Metabolomic signature of type 1 diabetes-induced sensory loss and nerve damage in diabetic neuropathy[J]. J Mol Med, 2018(1): 1-17.
ZHENG L Q, ZHANG H L. Elevated serum homocysteine level in the development of diabetic peripheral neuropathy[J]. Genet Mol Res, 2015, 14(4): 15365-15375.
CHEN M, ZHENG H, WEI T. High Glucose-Induced PC12 Cell Death by Increasing Glutamate Production and Decreasing Methyl Group Metabolism[J]. Biomed Res Int, 2016(2016): 1-9.
LÓPEZ-DÍEZ R, SHEKHTMAN A, RAMASAMY R, et al. Cellular mechanisms and consequences of glycation in atherosclerosis and obesity[J]. Biochim Biophys Acta, 2016(1): 2244-2252.
YUAN W , ZHANG J , LI S, et al. Amine metabolomics of hyperglycemic endothelial cells using capillary LC-MS with isobaric tagging[J]. J Proteome Res, 2011, 10(11): 5242-5250.
MAGNUSSON M, LEWIS G D, ERICSON U, et al. A diabetes-predictive amino acid score and future cardiovascular disease[J]. Eur Heart J, 2012, 34(26): 1982-1989.
YUNOSUKE M, ATSUSHI Y, YAN Z, et al. Altered glucose metabolism and hypoxic response in alloxan-induced diabetic atherosclerosis in rabbits[J]. PLos One, 2017, 12(4): e0175976.
Effect of Jianpi Qinghua Formula on TIR and skeletal muscle of extremities in patients of initial type 2 diabetes with type of qi and yin deficiency
Clinical effect of Yajia Formula on severe subacute thyroiditis with heat⁃toxic congestion and blood⁃heat stagnation type
Exploring mechanism of celastrol in improving glycolipid metabolism disorders based on 1H⁃NMR metabolomics
Clinical effect of Tiaogan Jieyu Decoction in treating patients of perimenopausal emotional disorder with syndrome of blood deficiency and liver depression
Clinical observation of Tiaozhong Baoyuan Decoction in treatment of delayed healing of long bone fracture after operation
Related Author
No data
Related Institution
Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine
Department of Endocrinology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine
Department of Pharmacy,The Frist Affiliated Hospital of Zhengzhou University
Henan Key Laboratory of Precision Clinical Pharmacy, Zhengzhou University
Department of Scientific Research, The Frist Affiliated Hospital of Zhengzhou University