Exploring the potential mechanism of capsicum against colorectal cancer based on network pharmacology

Lisheng CHANG; Hongyu CHEN; Yingxuan ZHANG; Wenli CHENG

doi:10.16306/j.1008-861x.2022.S1.044

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Exploring the potential mechanism of capsicum against colorectal cancer based on network pharmacology

Experiment Research | 更新时间：2022-08-29

- Exploring the potential mechanism of capsicum against colorectal cancer based on network pharmacology
- Academic Journal of Shanghai University of Traditional Chinese Medicine Vol. 36, Issue S1, Pages: 204-209(2022)
- 作者机构：
  
  1.上海中医药大学附属曙光医院宝山分院肿瘤一科（上海　201999）
- 作者简介：
- 基金信息：
- DOI：10.16306/j.1008-861x.2022.S1.044
  CLC：
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畅立圣,陈红宇,张莹瑄等.基于网络药理学探讨辣椒抗大肠癌的潜在作用机制[J].上海中医药大学学报,2022,36(S1):204-209.

CHANG Lisheng,CHEN Hongyu,ZHANG Yingxuan,et al.Exploring the potential mechanism of capsicum against colorectal cancer based on network pharmacology[J].Academic Journal of Shanghai University of Traditional Chinese Medicine,2022,36(S1):204-209.
畅立圣,陈红宇,张莹瑄等.基于网络药理学探讨辣椒抗大肠癌的潜在作用机制[J].上海中医药大学学报,2022,36(S1):204-209. DOI： 10.16306/j.1008-861x.2022.S1.044.

CHANG Lisheng,CHEN Hongyu,ZHANG Yingxuan,et al.Exploring the potential mechanism of capsicum against colorectal cancer based on network pharmacology[J].Academic Journal of Shanghai University of Traditional Chinese Medicine,2022,36(S1):204-209. DOI： 10.16306/j.1008-861x.2022.S1.044.

摘要

目的,2,基于网络药理学方法分析辣椒抗大肠癌侵袭转移的潜在分子机制。,方法,2,通过TCMSP数据库收集辣椒的主要化学成分及其靶点，通过GeneCards、PharmGkb、OMIM、TTD数据库获取大肠癌相关的疾病靶点，并与活性成分作用靶点取交集即为药物与疾病的共同作用靶点。运用String数据库结合Cytoscape 3.8.2绘制辣椒-大肠癌共同靶点的蛋白相互作用网络图（PPI），筛选核心靶点。用DAVID数据库对关键靶点进行基因本体GO功能富集与KEGG通路分析。,结果,2,辣椒-大肠癌共同靶点260个，核心基因18个。通路分析显示辣椒参与多条大肠癌相关通路的调控，主要涉及PI3K-AKT 信号通路、MAPK信号通路、Ras信号通路等经典肿瘤信号通路。,结论,2,辣椒调控多个靶点，同一个靶点参与多个生物学过程和信号通路，辣椒可能通过多靶点、多通路发挥抗大肠癌侵袭转移作用。

Abstract

Objective： To analyze the potential molecular mechanism of capsicum against colorectal cancer invasion and metastasis based on network pharmacology.,Methods,2,The main chemical components and their targets of capsicum were collected from TCMSP database. The disease targets related to colorectal cancer were obtained from GeneCards， PharmGkb， OMIM and TTD databases， and their intersection with the targets of active ingredients was the common targets of drug and disease. The protein interaction network map （PPI） of capsicum-colorectal cancer common targets was drawn by String database and Cytoscape 3.8.2， and the core targets were screened. GO enrichment analysis and KEGG pathway analysis were performed on key targets using DAVID database.,Results,2,There were 260 common targets and 18 core genes including IGF1R， MAP2K1 and CHEK1. Pathway analysis showed that capsicum was involved in the regulation of several colorectal cancer related pathways， mainly involving the PI3K-AKT signaling pathway， MAPK signaling pathway， Ras signaling pathway and other classic tumor signaling pathways.,Conclusion,2,C,apsicum regulates multiple targets， and the same target participates in multiple biological processes and signaling pathways. ,C,apsicum may play an anti-invasion and metastasis role in colorectal cancer through multiple targets and pathways.

关键词

网络药理学辣椒大肠癌作用机制

Keywords

network pharmacologycapsicumcolorectal cancermechanism

references

SUNG H， FERLAY J， SIEGEL R L， et al. Global cancer statistics 2020： GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries［J］. CA Cancer J Clin. 2021， 71（3）： 209-249.

郑莹，王泽洲. 全球结直肠癌流行数据解读［J］. 中华流行病学杂志，2021， 42（1）： 149-152.

SONG M， CHAN A T， SUN J. Influence of the Gut Microbiome， Diet， and Environment on Risk of Colorectal Cancer［J］. Gastroenterology. 2020， 158（2）： 322-340.

邹学校，马艳青，戴雄泽，等.辣椒在中国的传播与产业发展［J］. 园艺学报，2020， 47（9）： 1715-1726.

张莉华，肖尚月，陈少军.基于系统药理学探讨辣椒素潜在作用靶点的研究［J］.安徽农业科学，2020， 48（22）： 161-165.

GAO N， YANG F， CHEN S， et al. The role of TRPV1 ion channels in the suppression of gastric cancer development［J］. J Exp Clin Cancer Res. 2020， 39（1）： 206.

WU D， JIA H， ZHANG Z， et al. Capsaicin suppresses breast cancer cell viability by regulating the CDK8/PI3K/Akt/Wnt/βcatenin signaling pathway［J］. Mol Med Rep， 2020， 22（6）： 4868-4876.

NISARI M， ERÖZ R. Does capsaicin have therapeutic benefits in human colon adenocarcinoma？ Selection of the most reliable dose via AgNOR［J］. Turk J Med Sci， 2020， 50（4）： 1076-1081.

ISLAM A， YANG Y T， WU W H， et al. Capsaicin attenuates cell migration via SIRT1 targeting and inhibition to enhance cortactin and β-catenin acetylation in bladder cancer cells［J］. Am J Cancer Res. 2019， 9（6）： 1172-1182.

POPESCU G D A， SCHEAU C， BADARAU I A， et al. The Effects of Capsaicin on Gastrointestinal Cancers［J］. Molecules， 2020， 26（1）： 94.

吴春晓，顾凯，龚杨明，等. 2015年中国结直肠癌发病和死亡情况分析［J］.中国癌症杂志，2020， 30（4）： 241-245.

DU Y， LV Y， ZHA W， et al. Chili Consumption and Risk of Gastric Cancer： A Meta-Analysis［J］. Nutr Cancer， 2021， 73（1）： 45-54.

GAO N， YANG F， CHEN S， et al. The role of TRPV1 ion channels in the suppression of gastric cancer development［J］. J Exp Clin Cancer Res， 2020， 39（1）： 206.

HOU N， HE X， YANG Y， et al. TRPV1 Induced Apoptosis of Colorectal Cancer Cells by Activating Calcineurin-NFAT2-p53 Signaling Pathway［J］. Biomed. Res. Int， 2019， 2019： 6712536.

NISARI M， ERÖZ R. Has capsaicin therapeutic benefits in human colon adenocarcinoma？ Selection of the most reliable dose via AgNOR［J］. T urk J Med Sci， 2020， 50： 1076-1081.

HUMEAU J， BRAVO-SAN PEDRO JM， et al. Calcium signaling and cell cycle： Progression or death［J］. Cell Calcium， 2018， 70： 3-15.

GUEGUINOU M， CROTTÈS D， CHANTÔME A， et al. The SigmaR1 chaperone drives breast and colorectal cancer cell migration by tuning SK3-dependent Ca（2+） homeostasis［J］. Oncogene， 2017， 36： 3640-3647.

CAETANO B F R， TABLAS M B， IGNOTI M G， et al. Capsaicin lackstumor-promoting effects during colon carcinogenesis in a rat model induced by 1，2-dimethylhydrazine［J］. Environ Sci Pollut Res Int， 2021， 28（2）： 2457-2467.

CSEK˝ O K， BECKERS B， KESZTHELYI D， et al. Role of TRPV1 and TRPA1 ion channels in inflammatory bowel diseases： potential therapeutic targets？［J］. Pharmaceuticals， 2019， 12： E48.

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SPH Xing Ling Sci.&Tech.Pharmaceutical Co.,Ltd.

Shanghai University of Traditional Chinese Medicine

Department of Oncology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine

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