Clinical observation of Fuyuan Tongluo Formula in treatment of stent implantation and restenosis of diabetic lower limb vascular disease

Yuqing DU; Guobin LIU; Hongfei WANG; Renyan HUANG; Weijing FAN; Xuhong WANG

doi:10.16306/j.1008-861x.2022.S1.010

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Clinical observation of Fuyuan Tongluo Formula in treatment of stent implantation and restenosis of diabetic lower limb vascular disease

Clinical Research | 更新时间：2022-08-29

- Clinical observation of Fuyuan Tongluo Formula in treatment of stent implantation and restenosis of diabetic lower limb vascular disease
- Academic Journal of Shanghai University of Traditional Chinese Medicine Vol. 36, Issue S1, Pages: 40-44(2022)
- 作者机构：
  
  1.上海中医药大学附属曙光医院血管外科（上海　201203）
- 作者简介：
- 基金信息：
- DOI：10.16306/j.1008-861x.2022.S1.010
  CLC：
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杜玉青,柳国斌,王宏飞等.复原通络方治疗糖尿病下肢血管病变支架植入再狭窄的临床观察[J].上海中医药大学学报,2022,36(S1):40-44.

DU Yuqing,LIU Guobin,WANG Hongfei,et al.Clinical observation of Fuyuan Tongluo Formula in treatment of stent implantation and restenosis of diabetic lower limb vascular disease[J].Academic Journal of Shanghai University of Traditional Chinese Medicine,2022,36(S1):40-44.
杜玉青,柳国斌,王宏飞等.复原通络方治疗糖尿病下肢血管病变支架植入再狭窄的临床观察[J].上海中医药大学学报,2022,36(S1):40-44. DOI： 10.16306/j.1008-861x.2022.S1.010.

DU Yuqing,LIU Guobin,WANG Hongfei,et al.Clinical observation of Fuyuan Tongluo Formula in treatment of stent implantation and restenosis of diabetic lower limb vascular disease[J].Academic Journal of Shanghai University of Traditional Chinese Medicine,2022,36(S1):40-44. DOI： 10.16306/j.1008-861x.2022.S1.010.

摘要

目的,2,观察复原通络方治疗糖尿病下肢血管病变支架植入再狭窄的临床疗效。,方法,2,纳入糖尿病下肢血管病变支架植入再狭窄患者60例，随机分为中药组和对照组，每组各30例。两组均给予降糖、降压等西医常规治疗，在此基础上，中药组给予复原通络方，治疗6个疗程（4周为l个疗程）。比较两组患者临床总有效率、6 min步行和跛行距离、下肢踝肱指数（ABI）、经皮氧分压（TcPO,2,）、下肢动脉内径及安全性指标。,结果,2,①治疗6个月后，中药组总有效率90.0%，对照组总有效率80.0%，中药组的疗效优于对照组（,P,<,0.05）。②术后3个月、6个月中药组6 min步行距离显著长于对照组（,P,<,0.05）；术后6个月中药组6 min跛行距离显著长于对照组（,P,<,0.05）。③中药组静息ABI、TcPO,2,较对照组明显增加（,P,<,0.05）。④术后3个月、6个月，中药组患者股动脉、腘动脉、胫后动脉内径增宽优于照组（,P,<,0.05）。,结论,2,复原通络方能够改善糖尿病下肢血管病变支架植入再狭窄的临床症状，促进下肢血运重建，延缓再狭窄的发生。

Abstract

Objective： To explore the clinical efficacy of Fuyuan Tongluo Formula in the treatment of stent implantation and restenosis of diabetic lower limb vascular disease.,Methods,2,Sixty patients with stent implantation and restenosis of diabetic lower limb vascular disease were randomly divided into traditional Chinese medicine group and control group， 30 cases in each group. Both groups were treated with routine western medicine such as hypoglycemic and anti-hypertensive drugs. On this basis， the traditional Chinese medicine group was treated with Fuyuan Tongluo Formula for 6 treatment courses （4 weeks as one treatment course）. The total clinical effective rate， 6-minute walking and claudication distance， ABI， TcPO,2,， lower extremity artery diameter and safety indexes were compared between the two groups.,Results,2,①After treatment for 6 months， the total effective rate of the traditional Chinese medicine group was 90.0%， and that of the control group was 80.0%. The efficacy of the traditional Chinese medicine group was better than that of the control group （,P,<,0.05）. ②Three and six months after operation， the 6-minute walking distance in the traditional Chinese medicine group was significantly longer than that in the control group （,P,<,0.05）. Six months after operation， the 6-minute claudication distance in the traditional Chinese medicine group was significantly longer than that in the control group （,P,<,0.05）. ③The resting ABI and TcPO,2, in the traditional Chinese medicine group were significantly higher than those in the control group （,P,<,0.05）. ④Three and six months after operation， the diameters of femoral artery， popliteal artery and posterior tibial artery in the traditional Chinese medicine group were wider than those in the control group （,P,<,0.05）.,Conclusion,2,Fuyuan Tongluo Formula can improve the clinical symptoms of stent implantation and restenosis of diabetic lower limb vascular disease， promote the revascularization of lower extremities， and delay the occurrence of restenosis.

关键词

复原通络方糖尿病下肢血管病变支架植入再狭窄临床疗效

Keywords

Fuyuan Tongluo Formuladiabetic lower limb vascular diseasestent implantationrestenosisclinical efficacy

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