Objective： To observe the efficacy of Miniao Paishi Mixture on removing residual stones after extracorporeal shock wave lithotripsy （ESWL） of renal calculi.,Methods,2,Ninety patients with renal calculi were randomly divided into the control group and observation group， 45 cases in each group. Both groups were treated with ESWL on the day of admission. After operation， the patients drank 2 500-3 000 ml of water every day and do jumping exercise appropriately. The control group was treated with tamsulosin hydrochloride sustained-release capsule on this basis， and the observation group was treated with Miniao Paishi Mixture based on the treatment for the control group， with a course of 4 weeks. The clinical efficacy and the stone excretion were observed， the changes of clinical symptom scores and related indexes of renal function were compared， and the safety was evaluated.,Results,2,①The clinical efficacy of the observation group was better than that of the control group （,P,<,0.05）. ② After treatment， the clinical symptom scores of the two groups were decreased （,P,<,0.05）， and the clinical symptom scores of the observation group were less than those of the control group （,P,<,0.05）. ③The removal rate of residual stone in the observation group was higher than that in the control group （,P,<,0.05）， the stone removal time and disappear time in the observation group were less than those in the control group （,P,<,0.05）， and the recurrence rate of the observation group was lower than that of the control group （,P,<,0.05）. ④After treatment， the levels of serum creatinine and urea nitrogen in the two groups were decreased （,P,<,0.05）， and the levels of serum creatinine and urea nitrogen in the observation group were lower than those in the control group （,P,<,0.05）. ⑤There were no obvious adverse reaction in both groups.,Conclusion,2,Miniao Paishi Mixture can effectively improve the stone clearance rate after ESWL， alleviate local clinical symptoms， improve patients’ renal function， and has high safety.