Evaluation of clinical efficacy of integrated traditional Chinese and western medicine in chronic obstructive pulmonary disease patients at stable stage based on randomized controlled trial and repeated measurement design

Xiulian ZHANG; Pinxian HUANG; Yechang QIAN; Lei WEI; Fangying LIU; Zhongfu WANG; Guoyi HUANG

doi:10.16306/j.1008-861x.2022.S1.002

您当前的位置：

首页 >

文章列表页 >

Evaluation of clinical efficacy of integrated traditional Chinese and western medicine in chronic obstructive pulmonary disease patients at stable stage based on randomized controlled trial and repeated measurement design

Clinical Research | 更新时间：2022-08-29

- Evaluation of clinical efficacy of integrated traditional Chinese and western medicine in chronic obstructive pulmonary disease patients at stable stage based on randomized controlled trial and repeated measurement design
- Academic Journal of Shanghai University of Traditional Chinese Medicine Vol. 36, Issue S1, Pages: 4-11(2022)
- 作者机构：
  
  1.上海中医药大学附属曙光医院宝山分院（上海　200437）
  2.上海中医药大学中医信息科学与技术研究中心（上海　201203）
- 作者简介：
- 基金信息：
- DOI：10.16306/j.1008-861x.2022.S1.002
  CLC：
扫描看全文
张秀莲,黄品贤,钱叶长等.基于双盲随机对照实验和重复测量设计评价中西医结合治疗慢性阻塞性肺疾病稳定期患者的临床疗效[J].上海中医药大学学报,2022,36(S1):4-11.

ZHANG Xiulian,HUANG Pinxian,QIAN Yechang,et al.Evaluation of clinical efficacy of integrated traditional Chinese and western medicine in chronic obstructive pulmonary disease patients at stable stage based on randomized controlled trial and repeated measurement design[J].Academic Journal of Shanghai University of Traditional Chinese Medicine,2022,36(S1):4-11.
张秀莲,黄品贤,钱叶长等.基于双盲随机对照实验和重复测量设计评价中西医结合治疗慢性阻塞性肺疾病稳定期患者的临床疗效[J].上海中医药大学学报,2022,36(S1):4-11. DOI： 10.16306/j.1008-861x.2022.S1.002.

ZHANG Xiulian,HUANG Pinxian,QIAN Yechang,et al.Evaluation of clinical efficacy of integrated traditional Chinese and western medicine in chronic obstructive pulmonary disease patients at stable stage based on randomized controlled trial and repeated measurement design[J].Academic Journal of Shanghai University of Traditional Chinese Medicine,2022,36(S1):4-11. DOI： 10.16306/j.1008-861x.2022.S1.002.

摘要

目的,2,评价黄芪注射液穴位注射联合舒利迭治疗慢性阻塞性肺疾病（COPD）稳定期患者的临床疗效。,方法,2,纳入95例COPD稳定期患者，采用随机双盲对照研究，将患者随机分为治疗组48例和对照组47例。治疗组患者给予黄芪注射液穴位注射联合舒利迭治疗，对照组患者给予生理盐水穴位注射联合舒利迭治疗，疗程均为3个月。每周应用COPD临床症状分级量化表记录患者的临床症状及治疗期间的不良反应发生情况。采用EpiData 3.0软件进行数据管理，SPSS 26.0统计软件进行数据分析。,结果,2,两组COPD稳定期患者的临床疗效比较，差异有统计学意义（,P,<,0.05），且临床疗效与治疗时间呈线性相关关系（,P,<,0.05），组别是影响两组患者临床疗效评价的主要因素，治疗组的临床疗效优于对照组。,结论,2,黄芪注射液穴位注射联合舒利迭治疗COPD稳定期患者的临床疗效优于舒利迭单药治疗，且临床疗效随治疗时间的延长而提高，该治疗方案安全有效，临床中适当延长治疗疗程能使患者受益更多。

Abstract

Objective： To evaluate the clinical efficacy of acupoint injection of astragalus injection combined with seretide on chronic obstructive pulmonary disease （COPD） at stable stage.,Methods,2,Ninety-five patients with stable COPD were enrolled in a randomized double-blind controlled study， and randomly divided into the treatment group （,n,=48） and the control group （,n,=47）. The patients in the treatment group were given acupoint injection of astragalus injection combined with seretide， and the patients in the control group were given normal saline injection combined with seretide for 3 months. The clinical symptoms and the occurrence of adverse reactions during treatment were recorded weekly with COPD clinical symptom grading quantification table. EpiData3.0 software was used for data management， and SPSS 26.0 statistical software was used for data analysis.,Results,2,There was statistically significant difference between the two groups in the clinical efficacy of patients with stable COPD （,P,<,0.05）. And there was a linear correlation between the clinical efficacy and treatment time （,P,<,0.05）. Group was the main factor affecting the clinical efficacy evaluation of the two groups， and the clinical efficacy of the treatment group was better than that of the control group.,Conclusion,2,The clinical efficacy of astragalus injection combined with seretide in the treatment of stable COPD is better than that of seretide group， and the clinical efficacy increases with the extension of treatment time. This treatment method is safe and effective. In clinic， patients can benefit more by appropriately prolonging the treatment course.

关键词

慢性阻塞性肺疾病稳定期疗程重复测量设计疗效评价

Keywords

Chronic obstructive pulmonary diseasestable stagecourse of treatmentrepeated measurement designcurative effect evaluation

references

赵栋梁，黄艳，李风雷，等. 中医综合肺康复联合西药治疗慢性阻塞性肺疾病稳定期30例［J］. 中医研究， 2020， 33（8）： 17-20.

陈红宇，陈文莉，畅立圣，等. 黄芪注射液穴位注射治疗化疗后白细胞减少症的临床研究［J］. 上海中医药杂志， 2020， 54（1）： 32-34.

韦丽萍，齐建华，梁谊深，等. 穴位注射黄芪注射液结合神阙灸治疗腹泻型肠易激综合征的临床观察［J］. 中国医药科学， 2020， 10（15）： 240-242， 253.

鲜文. 重组人BNP联合黄芪注射液对AMI PCI术后心力衰竭患者心功能及血清炎症因子的影响［J］. 心血管康复医学杂志， 2019， 28（4）： 424-428.

冯秀莉，曹延伦，任欣欣，等. 益气润肺汤联合黄芪注射液对耐药肺结核患者临床症状及机体免疫功能影响［J］. 世界中西医结合杂志， 2019， 14（10）： 1423-1426， 1430.

张善宝，王小玉，漆映辉，等. 黄芪注射液对DKD（CKD3期）患者氧化应激状态、胰岛素抵抗及肾功能的影响［J］. 中国中西医结合肾病杂志， 2020（6）： 497-500.

龙漫，曹春浩，郑洲，等. 电针足三里通过调节Th1/Th2平衡改善迟发型过敏反应［J］. 湖北中医药大学学报， 2018， 20（1）： 24-27.

王文莉，黄迪君. 麦粒灸为主对脾虚泄泻患者免疫功能的影响［J］. 上海针灸杂志， 1998（3）： 20-21.

施茵，周珊玲. 足三里穴对神经-内分泌-免疫网络的调节作用［J］. 江西中医药大学学报， 2003， 15（2）： 37-39.

唐文芳，刘日辉，于雅琴，等. 2000-2014年中国40岁以上成人慢性阻塞性肺疾病患病率的Meta分析［J］. 吉林大学学报（医学版）， 2015， 41（5）： 961-968.

HAN M L K， POSTMA D， MANNINO D M， et al. Gender and chronic obstructive pulmonary disease： why it matters ［J］. Am J Respir Crit Care Med， 2012， 176（12）： 1179-1184.

张立春，汪伟，李艳斐，等. 不同慢性阻塞性肺疾病综合分组间的焦虑抑郁调查［J］. 医学研究杂志， 2014， 43（10）： 148-150.

Views

483

下载量

CSCD

CNKI被引量

Alert me when the article has been cited

提交

Tools

Publicity Resources

Clinical efficacy of “Shenqi Guben Decoction” in the treatment of chronic obstructive pulmonary disease at stable stage

Clinical experience of Chailing Jiangqi Decoction in treating acute exacerbation chronic obstructive pulmonary disease

Efficacy evaluation of improved TCM respiratory guidance technology based on comprehensive pulmonary rehabilitation management in treating patients with COPD at stable stage in southern Xinjiang

Effects of Atomization Inhalation of Chuan Ke Zhi Combined with Corticosteroid and Bronchodilators on Serum Inflammatory Cytokines and Immune Function in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease

Clinical Effect of “Peiyuan Guben Powder” in Treating Chronic Obstructive Pulmonary Disease

Related Author

No data

Related Institution

Department of Chinese Internal Medicine,Shanghai Jing’an District Hospital of Traditional Chinese Medicine

Department of Rehabilitation,Municipal Hospital of Traditional Chinese Medicine Affiliated to Shanghai University of Traditional Chinese Medicine

Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine

Shandong Guangrao County Hospital of Traditional Chinese Meicine

Department of Pulmonology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine

⁰