Objective： To observe the clinical effects of modified Xiaochaihu Decoction in the treatment of cancer related insomnia （CRI） with Shaoyang syndrome.,Methods,2,A total of 86 patients of CRI with Shaoyang syndrome were included and randomly divided into the treatment group and control group， 43 cases in each group. The patients in the treatment group were orally treated with modified Xiaochaihu Decoction and the patients in the control group were orally treated with estazolam tablet， with a course of 4 weeks. Before and after treatment， the score of Pittsburgh sleep quality index （PSQI）， the total score of traditional Chinese medical syndrome and the scores of three main symptoms including difficulty falling asleep， light sleep with easy awakening， night sleep with many dreams in the two groups were evaluated and compared. After treatment， the curative effects of traditional Chinese medical syndrome in the two groups were evaluated.,Results,2,In the course of treatment， 3 patients in the treatment group were removed or dropped off and 3 patients in the control group dropped off， finally 40 patients in the treatment group and 40 patients in the control group were included in the statistical analysis. After treatment， the PSQI score， the total score of traditional Chinese medical syndrome and the scores of three main symptoms in the two groups were significantly decreased compared with those before treatment （,P,<,0.05）， and the PSQI score， the total score of traditional Chinese medical syndrome and the symptom scores of light sleep with easy awakening and night sleep with many dreams in the treatment group were lower than those in the control group （,P,<,0.05）. After treatment， the total effective rates of traditional Chinese medical syndrome was 87.5% in the treatment group and 70.0% in the control group， and the curative effect of traditional Chinese medical syndrome in the treatment group was significantly better than that in the control group （,P,<,0.05）.,Conclusion,2,Modified Xiaochaihu Decoction has better curative effects in the treatment of CRI with Shaoyang syndrome， and can improve the sleep quality and the traditional Chinese medical syndrome of the patients， which is worth further popularizing in the clinic.