Clinical effect of Yajia Formula on severe subacute thyroiditis with heat⁃toxic congestion and blood⁃heat stagnation type

MIN Jie; LI Hong

doi:10.16306/j.1008-861x.2022.05.005

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Clinical effect of Yajia Formula on severe subacute thyroiditis with heat⁃toxic congestion and blood⁃heat stagnation type

Clinical Research | 更新时间：2022-11-01

- Clinical effect of Yajia Formula on severe subacute thyroiditis with heat⁃toxic congestion and blood⁃heat stagnation type
- Academic Journal of Shanghai University of Traditional Chinese Medicine Vol. 36, Issue 5, Pages: 22-26(2022)
- 作者机构：
  
  1.上海中医药大学附属龙华医院内分泌科（上海　200032）
- 作者简介：
- 基金信息：
- DOI：10.16306/j.1008-861x.2022.05.005
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闵婕,李红.亚甲方治疗热毒壅盛、血热夹瘀型重症亚急性甲状腺炎的临床疗效[J].上海中医药大学学报,2022,36(05):22-26.

MIN Jie,LI Hong.Clinical effect of Yajia Formula on severe subacute thyroiditis with heat⁃toxic congestion and blood⁃heat stagnation type[J].Academic Journal of Shanghai University of Traditional Chinese Medicine,2022,36(05):22-26.
闵婕,李红.亚甲方治疗热毒壅盛、血热夹瘀型重症亚急性甲状腺炎的临床疗效[J].上海中医药大学学报,2022,36(05):22-26. DOI： 10.16306/j.1008-861x.2022.05.005.

MIN Jie,LI Hong.Clinical effect of Yajia Formula on severe subacute thyroiditis with heat⁃toxic congestion and blood⁃heat stagnation type[J].Academic Journal of Shanghai University of Traditional Chinese Medicine,2022,36(05):22-26. DOI： 10.16306/j.1008-861x.2022.05.005.

摘要

目的,2,以强的松为对照，观察亚甲方治疗重症亚急性甲状腺炎（SAT）的临床疗效。,方法,2,选择热毒壅盛、血热夹瘀型重症SAT患者76例，随机分为治疗组和对照组，每组各38例。治疗组患者给予亚甲方颗粒剂口服，对照组患者给予醋酸泼尼松片口服，两组疗程均为8周。评价两组患者的临床疗效及中医证候疗效；比较两组患者的发热、甲状腺疼痛的缓解、消退时间及甲状腺B超改善情况；比较两组患者的不良反应发生率；疗程结束后继续随访3个月，比较两组患者的复发率。,结果,2,研究过程中，治疗组3例患者剔除或脱落，对照组3例患者剔除或脱落，最终纳入统计分析者治疗组35例、对照组35例。①治疗后，治疗组患者的临床总有效率为91.43%，对照组为85.71%，治疗组的疗效优于对照组（,P,<,0.05）；治疗后，治疗组患者的中医证候疗效总有效率为91.43%，对照组为62.86%，治疗组的中医证候疗效优于对照组（,P,<,0.05）。②治疗组患者的发热缓解、完全退热及甲状腺疼痛缓解、疼痛消退时间均较对照组明显延长（,P,<,0.05）。③治疗后，两组患者的甲状腺超声情况较治疗前均明显改善（,P,<,0.05），但组间比较差异无统计学意义（,P,>,0.05）。④研究过程中，治疗组的不良反应发生率为0%，对照组的不良反应发生率为22.86%，治疗组患者的不良反应发生率显著低于对照组（,P,<,0.01）。⑤治疗组的复发率为0%，对照组的复发率为36.67%，治疗组患者的复发率显著低于对照组（,P,<,0.01）。,结论,2,亚甲方治疗热毒壅盛、血热夹瘀型重症SAT患者具有较好的临床疗效，可有效改善患者的中医证候及甲状腺B超低回声状况，且不良反应少、复发率低。

Abstract

Objective： Taking prednisone as the control， to observe the clinical effect of Yajia Formula in the treatment of severe subacute thyroiditis （SAT）.,Methods,2,A total of 76 severe SAT patients with heat-toxic congestion and blood-heat stagnation type were selected and randomly divided into the treatment group and control group， 38 cases in each group. The patients in the treatment group were orally treated with Yajia Formula granules and the patients in the control group were orally treated with prednisone acetate tablets， with a course of 8 weeks. The clinical effect and the Chinese medical syndrome effect were evaluated in the two groups. The relief time and disappearance time of fever and thyroid pain and the improvement of thyroid ultrasonography were compared between the two groups. The incidences of adverse reactions were compared between the two groups. Follow-up for 3 months after the end of the treatment course， the recurrence rates of the two groups were compared.,Results,2,In the course of the research， 3 patients in the treatment group and 3 patients in the control group were eliminated or shed off， finally 35 patients in the treatment group and 35 patients in the control group were included in the statistical analysis. ①After treatment， the total clinical effective rates of the treatment group and the control group were 91.43% and 85.71% respectively， and the effect of the treatment group was better than that of the control group（,P,<,0.05）； after treatment， the total effective rates on Chinese medical syndrome in the treatment group and the control group were 91.43% and 62.86% respectively， and the effect on Chinese medical syndrome in the treatment group was better than that in the control group （,P,<,0.05）. ②The relief time and disappearance time of fever and thyroid pain in the treatment group was significantly longer than that in the control group （,P,<,0.05）. ③After treatment， the condition of thyroid ultrasonography in the two groups was significantly improved compared with that before treatment （,P,<,0.05）， but there was no statistical difference between the two groups （,P,>,0.05）. ④In the course of the research， the incidences of adverse reactions in the treatment group and the control group were 0% and 22.86% respectively， and the incidence of adverse reactions in the treatment group was significantly lower than that in the control group （,P,<,0.01）. ⑤The recurrence rates of the treatment group and the control group were 0% and 36.67% respectively， and the recurrence rate of the treatment group was significantly lower than that of the control group （,P,<,0.01）.,Conclusion,2,Yajia Formula has better clinical effect in treating severe SAT patients with heat-toxic congestion and blood-heat stagnation type， and can improve the Chinese medical syndrome and the hypoechoic condition of thyroid ultrasonography with less adverse reactions and lower recurrence rate.

关键词

重症亚急性甲状腺炎热毒壅盛、血热夹瘀型亚甲方中医药疗法

Keywords

severe subacute thyroiditisheat-toxic congestion and blood-heat stagnation typeYajia Formulatraditional Chinese medicine therapy

references

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