Literature metrology study on acupuncture and moxibustion in treatment of infertility based on randomized controlled trials

Chuting WU; Qinfeng HUANG; Chen XIE; Guang YANG; Chunyan ZHANG

doi:10.16306/j.1008-861x.2022.04.013

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Literature metrology study on acupuncture and moxibustion in treatment of infertility based on randomized controlled trials

Theoretical Research | 更新时间：2022-08-29

- Literature metrology study on acupuncture and moxibustion in treatment of infertility based on randomized controlled trials
- Academic Journal of Shanghai University of Traditional Chinese Medicine Vol. 36, Issue 4, Pages: 84-91(2022)
- 作者机构：
  
  1.上海中医药大学附属岳阳中西医结合医院（上海　200437）
  2.上海市针灸经络研究所（上海　200030）
- 作者简介：
- 基金信息：
- DOI：10.16306/j.1008-861x.2022.04.013
  CLC：
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吴楚婷,黄琴峰,谢晨等.基于随机对照试验针灸治疗不孕症的文献计量学研究[J].上海中医药大学学报,2022,36(04):84-91.

WU Chuting,HUANG Qinfeng,XIE Chen,et al.Literature metrology study on acupuncture and moxibustion in treatment of infertility based on randomized controlled trials[J].Academic Journal of Shanghai University of Traditional Chinese Medicine,2022,36(04):84-91.
吴楚婷,黄琴峰,谢晨等.基于随机对照试验针灸治疗不孕症的文献计量学研究[J].上海中医药大学学报,2022,36(04):84-91. DOI： 10.16306/j.1008-861x.2022.04.013.

WU Chuting,HUANG Qinfeng,XIE Chen,et al.Literature metrology study on acupuncture and moxibustion in treatment of infertility based on randomized controlled trials[J].Academic Journal of Shanghai University of Traditional Chinese Medicine,2022,36(04):84-91. DOI： 10.16306/j.1008-861x.2022.04.013.

摘要

目的,2,归纳分析针灸治疗不孕症的随机对照试验文献，总结针灸治疗不孕症的选穴规律、治疗方法规律、临床疗效及效应指标，为针灸治疗优势病症提供科学证据。,方法,2,采用计算机检索《中医针灸信息库》、中国知网（CNKI）、万方（Wanfang）、维普（CQVIP）数据库中2015年1月1日~2022年4月30日针灸治疗不孕症的文献，对符合纳入标准的文献中穴位和治疗方法进行分析总结，并比较不同病因不孕症及不同治疗方法对不孕症的总有效率、妊娠率、排卵率、子宫内膜厚度和血清性激素水平。,结果,2,共纳入文献407篇，以排卵障碍性不孕症最多。针灸治疗不孕症共涉及穴位129个，高频穴位为关元、三阴交、子宫、足三里、中极、气海、肾俞和太冲。聚类分析显示，高频穴位的有效聚类为血海-太冲-肾俞、气海-中极-足三里-子宫、三阴交-关元。穴位分布以任脉穴位和腹部穴位频次最高。常采用针刺、灸法联合中药或西药治疗。针灸治疗后不同病因不孕症的妊娠率和排卵率不同；对于排卵障碍性不孕患者，针灸+西药和针灸+中药的总有效率、妊娠率和排卵率均高于针灸疗法、西药和中药；针灸+西药治疗后患者子宫内膜厚度增加高于针灸疗法和针灸+中药疗法，且不同疗法均能调节性激素水平。,结论,2,针灸治疗不孕症选穴以局部穴位为主，结合经脉所主病选穴，关元和三阴交可作用主穴。针灸疗法单独应用或联合药物应用均能有效提高患者的妊娠率和排卵率，增加子宫内膜厚度，调节性激素水平。不孕症可作为针灸优势病症。

Abstract

Objective： To summarize and analyze the literatures of randomized controlled trials of acupuncture and moxibustion in the treatment of infertility， and to summarize the laws of acupoints selection， treatment methods， clinical efficacy and effective indexes of acupuncture and moxibustion in the treatment of infertility so as to provide scientific evidence for the advantages of acupuncture and moxibustion in the treatment.,Methods,2,The literatures on acupuncture and moxibustion treatment of infertility from January 1， 2015 to April 30， 2022 in TCM Acupuncture Information Database， China national knowledge infrastructure （CNKI）， Wanfang academic journal full-text database （Wanfang） and Chongqing VIP database （CQVIP） databases were retrieved by computer， and the acupoints and treatment methods in the literatures met the inclusion criteria were analyzed and summarized. The total effective rate， pregnancy rate， ovulation rate， endometrial thickness， and serum sex hormone levels of infertility of different etiologies and different treatment methods were compared.,Results,2,A total of 407 literatures were included， most of which were ovulatory dysfunction infertility. Acupuncture and moxibustion treatment of infertility involved 129 acupoints， with high-frequency acupoints being Guanyuan， Sanyinjiao， Zigong， Zusanli， Zhongji， Qihai， Shenshu and Taichong. Cluster analysis showed that the effective clustering of high-frequency acupoints are Xuehai-Taichong-Shenshu， Qihai-Zhongji-Zusanli-Zigong and Sanyinjiao-Guanyuan. The frequency of acupoint distribution was highest on Ren Channel and abdominal acupoints. Acupuncture and moxibustion combined with traditional Chinese medicine or western medicine were often used for treatment. After acupuncture and moxibustion treatment， the pregnancy rate and ovulation rate of infertility of different etiologies were different. For patients with ovulatory dysfunction infertility， the total effective rate， pregnancy rate and ovulation rate of acupuncture + western medicine group and acupuncture + traditional Chinese medicine group were higher than those of acupuncture group， western medicine group and traditional Chinese medicine group. The increase of endometrial thickness of acupuncture + western medicine group was higher than that of acupuncture group and acupuncture + traditional Chinese medicine group， and different treatments could all regulate the level of sex hormones.,Conclusions,2,Acupuncture and moxibustion treatment of infertility are mainly based on local acupoints， and to determine acupoints per meridians dominated the disease， Guanyuan and Sanyinjiao can be treated as the main acupoints. Acupuncture and moxibustion therapy alone or combined with drugs can both effectively improve pregnancy rate and ovulation rate， increase endometrial thickness， regulate the level of sex hormones in patients. Acupuncture and moxibustion has the superior advantages in the treatment of infertility.

关键词

针灸疗法不孕症女性随机对照试验

Keywords

acupuncture and moxibustion therapyinfertilityfemalerandomized controlled trial

references

谢辛，孔北华，段涛，等. 妇产科学［M］. 9版. 北京：人民卫生出版社，2018： 61.

World Health Organization. Meeting to develop a global consensus on preconception care to reduce maternal and childhood mortality and morbidity：meeting report of World Health Organization Headquarters Geneva 6-7 February 2012［R］. Geneva： WHO， 2013.

孙文希，胡凌娟. 国内外不孕不育症现状及我国的干预策略探讨［J］. 人口与健康，2019（12）： 19-23.

寇彩云. 女性不孕症及其影响因素的流行病学研究分析［J］. 山西职工医学院学报，2017， 27（1）： 50-51.

谢奇君，李欣，赵纯，等. 辅助生殖技术相关并发症的研究进展［J］. 国际生殖健康/计划生育杂志，2021， 40（3）： 204-208.

BOVEY M，LORENC A，ROBINSON N. Extent of acupuncture practice for infertility in the United Kingdom： experiences and perceptions of the practitioners［J］. Fertil Steril， 2010， 94（7）： 2569-2573.

陈子江，刘嘉茵，黄荷凤，等. 不孕症诊断指南［J］. 中华妇产科杂志，2019， 54（8）： 505-511.

连方. 不孕症中医文献的研究［D］. 济南：山东中医药大学，2002.

许淑怡，叶骞，叶平. 古代医家对不孕症的认识［J］. 吉林中医药，2009， 29（4）： 350-352.

艾潇，王琳，易玮，等. 针灸治疗排卵障碍性不孕的Meta分析［J］. 中医药导报，2017， 23（20）： 62-66.

黄守强，徐海燕，熊俊，等. 针灸治疗多囊卵巢综合征不孕症有效性的系统评价［J］. 中国循证医学杂志，2021， 21（4）： 431-437.

胡玉姣，陈昊，夏有兵. 针灸治疗输卵管阻塞性不孕症的Meta分析［J］. 辽宁中医杂志，2018， 45（12）： 2469-2473.

黄琴峰，谢晨，吴焕淦，等. 基于文献计量的针灸病谱与适宜病症研究［J］. 中国针灸，2021， 41（9）： 1055-1059.

蔡靓，李丽，赵以琳，等. 补肾健脾针刺法对行IVF-ET治疗不孕症患者拮抗剂方案促排卵的影响［J］.上海针灸杂志，2021， 40（1）： 49-53.

罗丹，李雅彦，赵利华. 三阴交穴治疗妇科疾病疗效及相关机制的研究进展［J］. 针灸临床杂志，2015， 31（4）： 88-90.

任凤兰，杨连杰，刘玉春. 针药并用治疗肾虚肝郁型多囊卵巢综合征不孕的疗效观察［J］. 上海针灸杂志，2022， 41（1）： 43-49.

程凯，田素领. 逆针“关元”“三阴交”对去卵巢大鼠下丘脑-垂体-卵巢轴的影响［J］. 针刺研究，2012， 37（1）： 15-19，45.

胡玲，汪惠丽，高忻洙，等. 电针“关元”与“三阴交”对围绝经期模型大鼠性激素及下丘脑β-EP调整作用的比较［J］. 中国针灸，2004， 24（9）： 59-61.

任晓暄，朱兵，高昕妍，等. 针刺不同穴位对雌性大鼠下丘脑GnRH相关神经元活动的影响［J］. 北京中医药大学学报，2010， 33（3）： 191-195， 199.

张维怡，黄光英，刘洁，等. 针刺对多囊卵巢综合征大鼠卵巢TGF-α、EGFR表达的影响［J］. 微循环学杂志，2008， 18（4）： 4-7.

HUANG Q F. Exploration of Clinical Regularities in Acupuncture-moxibustion Treatment for Infertility［J］. J Acupunct Tuina Sci， 2012， 10（2）： 72-76.

石学敏. 针灸学［M］. 北京：中国中医药出版社，2017： 17.

KARAKAS S E. New biomarkers for diagnosis and management of polycystic ovary syndrome［J］. Clin Chim Acta， 2017， 471： 248-253.

陈士岭. 卵巢储备功能的评价［J］. 国际生殖健康/计划生育杂志，2009， 28（5）： 281-286.

王亚楠，赵映，余思奕，等. JAMA“针刺联合克罗米芬治疗多囊卵巢综合征不孕症”引发的思考［J］.中国针灸，2017， 37（12）： 1342-1346.

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