Objective： A multi-component quality control method for Sanjiu Weitai capsule was established based on high performance liquid chromatography（HPLC）-quantitative analysis of multi-component by single marker （QAMS） method. Taking this method as an example， the feasibility of HPLC-QAMS method for multi-components quality control of Chinese patent medicine compound preparation was discussed.,Methods,2,The high-performance liquid chromatography method was used， performed on an Aglient TC C,18, column （4.6 mm×250 mm， 5 μm） at a flow rate of 1.0 ml/min with acetonitrile-0.1% phosphoric acid solution as the mobile phase （gradient elution）. The column temperature was 30 ℃， the detection wavelength was 230 nm， and the injection volume was 10 μl. The relative correction factor （RCF） of skimmianine， dictamnine， evolitrine， albiflorin， benzoyl paeoniflorin， costunolide and dehydrocostus lactone was established by QAMS method with paeoniflorin as an internal standard. The contents of index components were calculated and compared with those determined by external standard method to verify the feasibility of multiple evaluation by HPLC-QAMS method.,Results,2,Skimmianine， dictamnine， evolitrine， albiflorin， paeoniflorin， benzoyl paeoniflorin， costunolide and dehydrocostus lactone showed good linear relationships within the ranges of 0.69-17.25， 0.96-24.00， 1.39-34.75， 11.58-289.50， 27.06-676.50， 1.82-45.50， 14.69-367.25 and 17.86-446.50 μg/ml （,r,>,0.999）， whose average recovery rates （relative standard deviations） were 97.87% （1.25%）， 96.98% （1.55%）， 99.65% （0.96%）， 100.01% （0.63%）， 99.86% （0.71%）， 98.03% （1.70%）， 100.08% （0.67%） and 98.80% （0.92%）， respectively. There was no significant difference between the calculated results of HPLC-QAMS method and the measured results of external standard method （,P,>,0.05）.,Conclusion,2,The established HPLC-QAMS method is easy to operate and accurate， which can be used for the quality control of Sanjiu Weitai capsule. The study also shows that HPLC-QAMS method is reasonable and feasible for the QAMS of multi-index components in Chinese patent medicine compound preparations.