Objective： To observe the clinical efficacy of Tiaogan Jieyu Decoction in the treatment of perimenopausal emotional disorder， and preliminarily explore its mechanism based on neuropeptide regulation.,Methods,2,A total of 101 patients of perimenopausal emotional disorder with liver stagnation and blood deficiency type were selected and randomly divided into the treatment group （51 cases） and control group （50 cases）. The patients in both groups were treated with basic psychological counseling. Meanwhile， the patients in the treatment group were orally treated with Tiaogan Jieyu Decoction and the patients in the control group were orally treated with Gengnianning. The treatment course of both groups was 8 weeks. Before and after treatment， the total scores of Chinese medical symptoms and main symptom scores between the two groups were compared， and the scores of Greene menopause scale， self-rating anxiety scale （SAS） and self-rating depression scale （SDS） of the two groups were evaluated and compared. Before and after treatment， the levels of estradiol （E,2,）， follicle stimulating hormone （FSH）， luteinizing hormone （LH）， testosterone （T）， progesterone （P）， prolactin （PRL） and β-endorphins （β-EP）， serotonin （5-HT）， norepinephrine （NE） and dopamine （DA） were detected and compared.,Results,2,①After treatment， the total scores of Chinese medical symptoms in the two groups were significantly decreased compared with those before treatment （,P,<,0.01）， and the score in the treatment group was significantly lower than that in the control group （,P,<,0.01）. ②After treatment， the scores of main symptoms （such as tidal fever and sweatiness， depression， etc） in the two groups were decreased compared with those before treatment （,P,<,0.05， ,P,<,0.01）， and the scores of main symptoms （such as tidal fever and sweatiness， depression， anxiety， etc） in the treatment group were lower than those in the control group （,P,<,0.05， ,P,<,0.01）. ③After treatment， the scores of Greene menopause scale in the two groups were significantly decreased compared with those before treatment （,P,<,0.01）， and the score of the treatment group was significantly lower than that of the control group （,P,<,0.01）. ④After treatment， the scores of SAS and SDS in the two groups were significantly decreased compared with those before treatment （,P,<,0.01）， and the scores of the treatment group were lower than those of the control group （,P,<,0.05）. ⑤After treatment， the levels of E,2, and P in the two groups were increased （,P,<,0.05， ,P,<,0.01）， the level of FSH was decreased （,P,<,0.01）， the level of LH in the treatment group was also decreased （,P,<,0.05）， and the levels of E,2, and P in the treatment group were higher than those in the control group （,P,<,0.05）， the level of FSH was lower than that in the control group （,P,<,0.05）. ⑥After treatment， the level of β-EP in the two groups was decreased compared with that before treatment （,P,<,0.05， ,P,<,0.01）， the level of 5-HT was increased （,P,<,0.05）， and the level of β-EP in the treatment group was lower than that in the control group （,P,<,0.05）.,Conclusion,2,Tiaogan Jieyu Decoction can effectively improve the clinical symptoms， anxiety and depression status in patients of perimenopausal emotional disorder with liver depression and blood deficiency type， and its mechanisms may be related to the regulation of neuropeptide levels such as neuroendocrine hormones， β-EP and 5-HT.