Study on effect of exosomes from different cell sources in tumor microenvironment on tumor drug resistance and intervention of traditional Chinese medicine
- Academic Journal of Shanghai University of Traditional Chinese Medicine Vol. 36, Issue 2, Pages: 1-8(2022)
- 作者机构：
1.上海中医药大学附属曙光医院（上海 201203）
- 作者简介：
- 基金信息：
DOI：10.16306/j.1008-861x.2022.02.001
CLC：
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卫真真,季青,朱惠蓉.肿瘤微环境中不同细胞来源外泌体对肿瘤耐药的影响及中医药干预研究[J].上海中医药大学学报,2022,36(02):1-8.
WEI Zhenzhen,JI Qing,ZHU Huirong.Study on effect of exosomes from different cell sources in tumor microenvironment on tumor drug resistance and intervention of traditional Chinese medicine[J].Academic Journal of Shanghai University of Traditional Chinese Medicine,2022,36(02):1-8.
卫真真,季青,朱惠蓉.肿瘤微环境中不同细胞来源外泌体对肿瘤耐药的影响及中医药干预研究[J].上海中医药大学学报,2022,36(02):1-8. DOI： 10.16306/j.1008-861x.2022.02.001.
WEI Zhenzhen,JI Qing,ZHU Huirong.Study on effect of exosomes from different cell sources in tumor microenvironment on tumor drug resistance and intervention of traditional Chinese medicine[J].Academic Journal of Shanghai University of Traditional Chinese Medicine,2022,36(02):1-8. DOI： 10.16306/j.1008-861x.2022.02.001.
摘要
外泌体是一种大小在40~160 nm的细胞外囊泡。在复杂的肿瘤微环境中，无论是肿瘤细胞还是各种基质细胞都会分泌特定的外泌体，并且肿瘤细胞通常会释放比普通细胞更多的外泌体。在肿瘤的发生发展中，外泌体通过自身携带的细胞因子介导细胞间通讯，影响肿瘤的转移、生长以及肿瘤细胞耐药性的传递等。通过探讨肿瘤微环境中肿瘤细胞、内皮细胞、间充质干细胞、肿瘤干细胞、肿瘤相关成纤维细胞及免疫细胞等不同细胞来源的外泌体与肿瘤耐药的关系，分析中药通过外泌体影响肿瘤耐药的相关研究，进一步阐述外泌体在肿瘤诊断和治疗中的研究前景，以期通过多种手段逆转肿瘤多药耐药，为患者带来新的治疗希望。
Abstract
Exosome is a kind of extracellular vesicle between 40 and 160 nm in size. In the complex tumor microenvironment， both tumor cells and various stromal cells can secrete specific exosomes， and the tumor cells usually release more exosomes than the ordinary cells. In the occurrence and development of tumors， the exosome mediates the intercellular communication through its own cytokines， which affects the metastasis and growth of tumor and the transmission of drug resistance of tumor cells and so on. This paper explores the relationship between tumor drug resistance and exosomes in the tumor microenvironment derived from different cells including tumor cells， endothelial cells， mesenchymal stem cells， tumor stem cells， tumor-associated fibroblasts and immune cells， analyzes the related research of traditional Chinese medicine affecting tumor drug resistance through exosomes， and further expounds the research prospects of exosomes in tumor diagnosis and treatment， in order to reverse the tumor multi-drug resistance through various means and bring the new treatment hope for the patients.
关键词
肿瘤微环境外泌体肿瘤耐药作用机制干预研究
Keywords
tumor microenvironmentexosometumor drug resistancemechanismintervention study
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