ZHU Senfa,YANG Guang,LI Wenjie,et al.Study on coatability of personalized gel plasters of traditional Chinese medicine based on characteristic physical properties of texture[J].Academic Journal of Shanghai University of Traditional Chinese Medicine,2022,36(01):63-74.
ZHU Senfa,YANG Guang,LI Wenjie,et al.Study on coatability of personalized gel plasters of traditional Chinese medicine based on characteristic physical properties of texture[J].Academic Journal of Shanghai University of Traditional Chinese Medicine,2022,36(01):63-74. DOI: 10.16306/j.1008-861x.2022.01.010.
Study on coatability of personalized gel plasters of traditional Chinese medicine based on characteristic physical properties of texture
Objective: To explore the correlation among the amount of matrix, the characteristic physical properties of texture (characteristic physical properties) of the paste before coating and the coatability of the strapping.,Methods,2,Taking the modeling quality and coatability of the strapping as the indicators, six important excipient matrices including partially neutralized sodium polyacrylate (NP700), aluminum glycolate and so on were selected for formulation design. The amount of each matrix was set to 5 levels, and a total of 30 prescriptions were obtained. The characteristic physical properties including spreadability, hardness, viscoelasticity and so on of 210 samples of the paste before coating which were from 30 different prescriptions and 7 different time points were measured by a texture analyzer. The correlation analysis, principal component analysis and other methods were used to process the data.,Results,2,With the increasing of the dosage of NP700, povidone K30 and tartaric acid and the ratio of oil phase, the indicators of characteristic physical properties of the paste before coating including spreadability, hardness, consistency, tensile strength, cohesion, rate of change and viscoelasticity were correspondingly increased. The suitable coating time was shortened, and the phenomenon of wrinkling was more likely appeared. After the principal component analysis on the characteristic physical property indicators of the samples, 210 samples can be clearly divided into two categories: coating and non-coating samples.,Conclusion,2,By reducing the amount of NP700, povidone K30 and tartaric acid and the ratio of oil phase, the characteristic physical property indicators of the paste before coating such as spreadability, hardness, consistency and cohesion can be decreased, so as to optimize the coatability of the strapping.
PATLOLLA V G R,HOLBROOK W P,GIZURARSON S,et al. Evaluation of in vitro mucoadhesiveness and texture profile analysis of doxycycline in situ hydrogels[J]. Pharmazie,2020,75(1) :7-12.
PATLOLLA V G R,PETER HOLBROOK W,GIZURARSON S,et al. Doxycycline and Monocaprin In Situ Hydrogel:Effect on Stability,Mucoadhesion and Texture Analysis and In Vitro Release[J]. Gels, 2019, 5(4): 47.
Exploration on compliance enhancement strategy of personalized traditional Chinese medicine preparations based on taste improvement
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Engineering Research Center of Modern Preparation Technology of Traditional Chinese Medicine, Ministry of Education, Shanghai University of Traditional Chinese Medicine
School of Pharmacy, Shanghai University of Traditional Chinese Medicine
Taizhou Medical New & Hi-tech Industrial Development Zone