Effects of super disintegrants on the disintegration and compactibility of Chinese medicine tablets with delayed disintegration

Yating YU; Haiyue ZHAO; Yanlong HONG; Lan SHEN; Lijie ZHAO; Yi FENG

doi:10.16306/j.1008-861x.2022.01.009

您当前的位置：

首页 >

文章列表页 >

Effects of super disintegrants on the disintegration and compactibility of Chinese medicine tablets with delayed disintegration

Special Column | 更新时间：2022-08-29

- Effects of super disintegrants on the disintegration and compactibility of Chinese medicine tablets with delayed disintegration
- Academic Journal of Shanghai University of Traditional Chinese Medicine Vol. 36, Issue 1, Pages: 58-62(2022)
- 作者机构：
  
  1.上海中医药大学中药现代制剂技术教育部工程研究中心（上海　201203）
  2.上海交通大学医学院附属第九人民医院药剂科（上海　200011）
  3.上海中医药大学中药学院（上海　201203）
  4.上海中医药大学中医健康服务协同创新中心（上海　201203）
- 作者简介：
- 基金信息：
- DOI：10.16306/j.1008-861x.2022.01.009
  CLC：
扫描看全文
余雅婷,赵海越,洪燕龙等.超级崩解剂对崩解延缓的中药片剂崩解及压缩成型性的影响[J].上海中医药大学学报,2022,36(01):58-62.

YU Yating,ZHAO Haiyue,HONG Yanlong,et al.Effects of super disintegrants on the disintegration and compactibility of Chinese medicine tablets with delayed disintegration[J].Academic Journal of Shanghai University of Traditional Chinese Medicine,2022,36(01):58-62.
余雅婷,赵海越,洪燕龙等.超级崩解剂对崩解延缓的中药片剂崩解及压缩成型性的影响[J].上海中医药大学学报,2022,36(01):58-62. DOI： 10.16306/j.1008-861x.2022.01.009.

YU Yating,ZHAO Haiyue,HONG Yanlong,et al.Effects of super disintegrants on the disintegration and compactibility of Chinese medicine tablets with delayed disintegration[J].Academic Journal of Shanghai University of Traditional Chinese Medicine,2022,36(01):58-62. DOI： 10.16306/j.1008-861x.2022.01.009.

摘要

目的,2,考察3种常用的超级崩解剂对崩解延缓的中药片剂崩解及压缩成型性的影响。,方法,2,以苦参水提物粉末为模型药物，以交联聚乙烯吡咯烷酮（PVPP）、交联羧甲基纤维素钠（CCMC-Na）、羧甲基淀粉钠（CMS）为崩解剂，考察载药量、不同崩解剂及其用量对苦参片剂崩解及压缩成型性的影响，并采用山楂叶醇提物进行验证。,结果,2,当苦参载药量为70%和80%时，加入不同崩解剂，制得片剂的崩解时限（DT）均>50 min。当载药量为50%时，分别加入10%用量的PVPP、CCMC-Na或CMS，制得片剂的DT分别为（29.00±2.19）min、（27.50±1.38）min、（41.17±0.98）min，PVPP和CCMC-Na的崩解性能无明显差异，但均优于CMS；加入10%PVPP后制得片剂的压片力为（57.57±2.69）MPa，小于含有CCMC-Na或CMS的处方片剂。验证性实验结果与上述结果一致。,结论,2,针对中药片剂的崩解延缓，降低载药量为50%时，加入以上3种超级崩解剂（10%）能够较好地解决崩解延缓的问题，且PVPP和CCMC-Na的崩解效果较好，PVPP的粉体成型性最优。

Abstract

Objective： To investigate the effects of three commonly used super disintegrants on the disintegration and compactibility of Chinese medicine tablets with delayed disintegration.,Methods,2,The aqueous extract powder of Sophorae Flavescentis Radix was taken as model drug， crospovidone （PVPP）， croscarmellose sodium （CCMC-Na） and carboxymethyl starch sodium （CMS） were taken as disintegrants. The effects of drug loading， disintegrants and their dosage on the disintegration and compactibility of tablets of Sophorae Flavescentis Radix were investigated. The alcohol extract of hawthorn leaf was used for verification.,Results,2,When the drug loading of Sophorae Flavescentis Radix was 70% and 80%， and different disintegrants were added， the disintegration time （DT） of all prepared tablets was more than 50 minutes. When the drug loading was 50%， PVPP， CCMC-Na or CMS were added respectively （at dosage of 10%）， the DTs of the prepared tablets were （29.00±2.19）min，（27.50±1.38）min and （41.17±0.98）min. There was no significant difference in the disintegration properties of PVPP and CCMC-Na， but they were better than CMS. After adding 10% PVPP， the pressure of the prepared tablets was （57.57±2.69） MPa， which was less than that of the prescription tablets containing CCMC-Na or CMS. The results of verification experiment were consistent.,Conclusion,2,For the disintegration delay of Chinese medicine tablets， when the drug loading is reduced to 50%， adding the above three super disintegrants （10%） can better solve the problem of disintegration delay， the disintegration effect of PVPP and CCMC-Na is better， and the powder compactibility of PVPP is the best.

关键词

超级崩解剂片剂中药直接压片崩解压缩性成型性

Keywords

super disintegranttabletChinese medicinedirect compactiondisintegrationcompressibilitycompactibility

references

LI X H， ZHAO L J， RUAN K P， et al. The application of factor analysis to evaluate deforming behaviors of directly compressed powders［J］. Powder Technol， 2013， 247： 47-54.

SNICK B V， HOLMAN J， CUNNINGHAM C， et al. Continuous direct compression as manufacturing platform for sustained release tablets［J］. Int J Pharm， 2017， 519（1-2）： 390-407.

LI Z， ZHAO L J， LIN X， et al. Direct compaction： An update of materials， trouble-shooting， and application［J］. Int J Pharm， 2017， 529： 543-556.

YU Y T， ZHAO L J， LIN X， et al. A model to simultaneously evaluate the compressibility and compactibility of a powder based on the compression ratio［J］. Int J Pharm， 2020， 577： 1-11.

DAI S Y， XU B， ZHANG Z， et al. A compression behavior classification system of pharmaceutical powders for accelerating direct compression tablet formulation design［J］. Int J Pharm， 2019， 572： 1-15.

张文，余雅婷，赵立杰，等.共聚维酮改善金银花粉末压缩成型性能的研究［J］.药学学报，2021， 56（8）： 2127-2135.

李哲. 中药复合粒子设计及其压片关键性能改善与机理研究［D］. 上海：上海中医药大学， 2019.

YU Y T， ZHAO L J， LIN X， et al. Research on the powder classification and the key parameters affecting tablet qualities for direct compaction based on powder functional properties［J］. Adv Powder Technol， 2021， 32 （2）： 565-581.

余雅婷，赵立杰，徐君杰，等.微晶纤维素对疏风解毒配方提取物粉末直压性能影响的研究［J］.中草药，2019， 50（17）： 4041-4050.

张梦珊，罗毓，张越，等.HPMC共喷雾干燥改善干姜醇提物压缩成型性的研究［J/OL］.中国中药杂志：1-10 ［2021-04-23］. https：//doi.org/10.19540/j.cnki.cjcmm. 20210422. 303https://doi.org/10.19540/j.cnki.cjcmm.20210422.303

YUAN J， SHI L， SUN W J， et al. Enabling direct compression of formulated danshen powder by surface engineering［J］. Powder Technol， 2013， 241： 211-218.

余雅婷. 适用于粉末直接压片工艺的中药片剂品质调控专家系统研究［D］. 上海：上海中医药大学， 2021.

赵克，吴强东，刘志婷.影响中药片剂崩解度的因素及解决方法［J］.中国药物经济学， 2014， 9（S1）： 78-79.

李金枝，冯金瑞，何恬，等.粉末直接压片技术及其辅料的应用与研究现状［J］.中国新药杂志，2015， 24（21）： 2467-2470， 2498.

Views

913

下载量

CSCD

CNKI被引量

Alert me when the article has been cited

提交

Tools

Publicity Resources

Influence of maintenance treatment with Chinese medicine on survival of patients with advanced colorectal cancer

Research progress of acute liver failure and acute-on-chronic liver failure in traditional Chinese and western medicine

Preparation of Periploca sepium periplosides tablets by optimizing powder direct compression process based on response surface methodology

Effects of neutrophil extracellular traps on ischemia-reperfusion injury and intervention of traditional Chinese medicine

Mechanism Research Progress of Chinese Medicine inthe Treatment of Vitiligo

Related Author

No data

Related Institution

Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine

Shanghai Municipal Hospital of Traditional Chinese Medicine Affiliated to Shanghai University of Traditional Chinese Medicine

Intensive Care Unit, Seventh People’s Hospital, Shanghai University of Traditional Chinese Medicine

Department of Emergency Medicine, Changzheng Hospital, Naval Medical University

Engineering Research Center of Modern Preparation Technology of Traditional Chinese Medicine, Ministry of Education, Shanghai University of Traditional Chinese Medicine

⁰