Study on powder properties of oily materials based on powder physical additivity properties of Chinese medicine—Taking Armeniacae Semen Amarum as an example
Special Column|更新时间:2022-08-29
|
Study on powder properties of oily materials based on powder physical additivity properties of Chinese medicine—Taking Armeniacae Semen Amarum as an example
Academic Journal of Shanghai University of Traditional Chinese MedicineVol. 36, Issue 1, Pages: 49-57(2022)
LI Yunqi,ZHANG Xue,CHEN Hengjin,et al.Study on powder properties of oily materials based on powder physical additivity properties of Chinese medicine—Taking Armeniacae Semen Amarum as an example[J].Academic Journal of Shanghai University of Traditional Chinese Medicine,2022,36(01):49-57.
LI Yunqi,ZHANG Xue,CHEN Hengjin,et al.Study on powder properties of oily materials based on powder physical additivity properties of Chinese medicine—Taking Armeniacae Semen Amarum as an example[J].Academic Journal of Shanghai University of Traditional Chinese Medicine,2022,36(01):49-57. DOI: 10.16306/j.1008-861x.2022.01.008.
Study on powder properties of oily materials based on powder physical additivity properties of Chinese medicine—Taking Armeniacae Semen Amarum as an example
Objective: To explore the additivity property characterics of Chinese medicine powder physical properties, and predict the powder physical properties of oily Chinese medicine Armeniacae Semen Amarum which is hard to crush applying Euclidean distance ratio.,Methods,2,The representative materials of five typical Chinese medicines including powdery, fibrous, brittle, sugar, and oily materials were Dioscoreae Rhizoma, Leonur Iherba, Ostreae Concha, Codonopsis Radix and Armeniacae Semen Amarum respectively. The fine powder of above Chinese medicines were mixed in pairs according to a certain proportion, and 26 powders of single or mixed Chinese medicines were obtained. The 15 physical parameters including bulk density, water absorption rate, maximum torque force and so on of 26 Chinese medicine powders were determined to characterize the basic properties, hydroscopicity and torque rheology of the Chinese medicine powders. The SIMCA-P 14.1 and Excel software were used to carry out the principal component analysis and correlation analysis. The predicted physical properties of Armeniacae Semen Amarum and the physical properties of the original 26 Chinese medicine powders were analyzed again by principal component analysis, and the correlation between the proportion of mixed powders and the weighted average score of principal components was verified.,Results,2,The, r ,value in the correlation equations between the weighted average score of physical property principal component and the mixing ratio of 8 Chinese medicine powder groups including Dioscoreae Rhizoma-Leonur Iherba group, Leonur Iherba-Ostreae Concha group, Dioscoreae Rhizoma-Armeniacae Semen Amarum group, Ostreae Concha-Armeniacae Semen Amarum group, and so on was 0.896-0.988. The powder physical properties of Armeniacae Semen Amarum was predicted by Euclidean distance ratio, and the correlation verification results between the weighted average score of principal component of physical properties and the mixing ratio of powders showed as follows:, r,=0.963 in Dioscoreae Rhizoma-Armeniacae Semen Amarum group, and ,r,=0.873 in Ostrea Concha-Armeniacae Semen Amarum group.,Conclusion,2,The powder with different physical properties has additive properties after mixing in a certain proportion, the powder physical properties of oily Chinese medicine such as Armeniacae Semen Amarum which is difficult to be crushed and screened alone, could be predicted through the above properties, so as to better guide the research and development of new drug and personalized preparation technology of Chinese medicine.
关键词
中药粉体粉体物理性质加和性苦杏仁中药临方制剂
Keywords
Chinese medicine powderphysical properties of powderadditive propertyArmeniacae Semen Amarumpersonalized traditional Chinese medicine preparation
SUÑÉ-NEGRE J M, PÉREZ-LOZANO P, ROIG M, et al. Optimization of parameters of the SeDeM Diagram Expert System: Hausner index (IH) and relative humidity (%RH)[J]. Eur J Pharm Biopharm, 2011, 79(2): 464-472.
LI Z, WU F, ZHAO L J, et al. Evaluation of fundamental and functional properties of natural plant product powders for direct compaction based on multivariate statistical analysis[J]. Adv Powder Technol, 2018, 29(11): 2881-2894.