Research progress on pharmacological activity and mechanism of timosaponin B-Ⅱ

WU Shuangmin; LI Zeyun; HOU Shuhan; DU Yue; YUAN Yongliang

doi:10.16306/j.1008-861x.2021.06.013

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Research progress on pharmacological activity and mechanism of timosaponin B-Ⅱ

Review | 更新时间：2022-09-09

- Research progress on pharmacological activity and mechanism of timosaponin B-Ⅱ
- Academic Journal of Shanghai University of Traditional Chinese Medicine Vol. 35, Issue 6, Pages: 92-96(2021)
- 作者机构：
  
  1.郑州大学第一附属医院药学部（河南　郑州　450052）
  2.河南省精准临床药学重点实验室（河南　郑州　450052）
  3.河南省宁陵县人民医院（河南　商丘　476700）
- 作者简介：
- 基金信息：
- DOI：10.16306/j.1008-861x.2021.06.013
  CLC：
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WU Shuangmin, LI Zeyun, HOU Shuhan, et al. Research progress on pharmacological activity and mechanism of timosaponin B-Ⅱ. [J]. Academic Journal of Shanghai University of Traditional Chinese Medicine 35(6):92-96(2021)
DOI：

WU Shuangmin, LI Zeyun, HOU Shuhan, et al. Research progress on pharmacological activity and mechanism of timosaponin B-Ⅱ. [J]. Academic Journal of Shanghai University of Traditional Chinese Medicine 35(6):92-96(2021) DOI： 10.16306/j.1008-861x.2021.06.013.

摘要

知母作为传统中药材，具有滋阴润燥、清热泻火等功效，临床应用广泛。知母皂苷B-Ⅱ（TB-Ⅱ）是知母的主要活性成分之一。现代药理研究发现，TB-Ⅱ具有多种药理活性，如抗阿尔茨海默病、抗抑郁、抗糖尿病及其并发症、抗骨质疏松、抗血小板聚集、抗炎、抗肿瘤等。总结近年来TB-Ⅱ药理活性及作用机制的相关研究进展，为TB-Ⅱ的新药开发和临床应用提供参考。

Abstract

As traditional Chinese herbal medicine, Anemarrhenae Rhizoma shows the efficacy of nourishing yin for moistening dryness as well as clearing heat-fire, which is widely applied in clinic.Timosaponin B-Ⅱ(TB-Ⅱ) is one of the main active components of Anemarrhenae Rhizoma.Modern pharmacological studies have found that TB-Ⅱ shows many pharmacological activities, such as anti-Alzheimer’s disease, anti-depression, anti-diabetes and its complications, anti-osteoporosis, anti-platelet aggregation, anti-inflammation and anti-tumor.The research progress related to the pharmacological activity and mechanism of TB-Ⅱ in recent years are summarized, so as to provide reference for the new drug development and clinical application of TB-Ⅱ.

关键词

知母皂苷B-Ⅱ药理活性作用机制综述

Keywords

timosaponin B-Ⅱpharmacological activitymechanismreview

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