Research advance on antiviral mechanism of herbal polysaccharides

BIAN Ya; GE Guangbo; DING Kan

doi:10.16306/j.1008-861x.2021.05.014

您当前的位置：

首页 >

文章列表页 >

Research advance on antiviral mechanism of herbal polysaccharides

Review | 更新时间：2022-09-09

- Research advance on antiviral mechanism of herbal polysaccharides
- Academic Journal of Shanghai University of Traditional Chinese Medicine Vol. 35, Issue 5, Pages: 89-96(2021)
- 作者机构：
  
  1.上海中医药大学交叉科学研究院（上海　201203）
  2.中国科学院上海药物研究所（上海　201203）
- 作者简介：
- 基金信息：
- DOI：10.16306/j.1008-861x.2021.05.014
  CLC：
扫描看全文
BIAN Ya, GE Guangbo, DING Kan. Research advance on antiviral mechanism of herbal polysaccharides. [J]. Academic Journal of Shanghai University of Traditional Chinese Medicine 35(5):89-96(2021)
DOI：

BIAN Ya, GE Guangbo, DING Kan. Research advance on antiviral mechanism of herbal polysaccharides. [J]. Academic Journal of Shanghai University of Traditional Chinese Medicine 35(5):89-96(2021) DOI： 10.16306/j.1008-861x.2021.05.014.

摘要

中药多糖是中药中重要的生物活性大分子，具有抗病毒、抗菌、抗炎、抗氧化、免疫调节、调节肠道菌群等多种药理活性。近年来，研究发现，中药多糖在抗病毒及缓解病毒引发的炎症反应等方面具有较为显著的优势和独特的作用机制，因此引起了国内外学者的广泛关注。系统综述中药多糖在抗病毒及缓解病毒引发相关症状方面的机制研究进展，包括直接杀灭病毒、阻止病毒黏附和侵袭、阻止病毒复制、调节免疫、抗炎、抗氧化以及调节肠道菌群等，以期为科学诠释中药复方抗病毒的作用机制和基于中药多糖的抗病毒药物开发提供参考。

Abstract

Polysaccharides are important bioactive macromolecules in Chinese medicines, with various pharmacological activities such as anti-viral, anti-bacteria, anti-inflammation, anti-oxidation, immune modulation and gut microbiota regulation.In recent years, studies have found that herbal polysaccharides showed significant advantages and unique mechanisms on anti-viral and alleviation of virus-caused inflammation, which attracted extensive attention at home and abroad.This article systematically reviews the research progress of herbal polysaccharides in anti-viral and relieving related symptoms induced by viruses, including directly killing viruses, preventing virus adhesion and invasion, preventing virus replication, regulating immunity, anti-inflammation, anti-oxidation and regulating gut microbiota, so as to provide reference for scientific interpretation of the anti-viral mechanism of Chinese medicine prescriptions and the anti-viral drugs development based on herbal polysaccharides.

关键词

中药多糖抗病毒作用机制新冠病毒综述

Keywords

herbal polysaccharidesanti-viralmechanismcorona virus disease 2019 (COVID-19)review

references

GROVE J，MARSH M. The cell biology of receptor-mediated virus entry[J]. J Cell Biol，2011，195(7)： 1071-1082.

ZHOU P，YANG X L，WANG X G，et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin[J]. Nature，2020，579(7798)： 270-273.

CVETKOVIC R S，GOA K L. Lopinavir/ritonavir： a review of its use in the management of HIV infection[J]. Drugs，2003，63(8)： 769-802.

NUKOOLKARN V，LEE S V，MALAISREE M，et al. Molecular dynamic simulations analysis of ritronavir and lopinavir as SARS-CoV 3CLpro inhibitors[J]. J Theor Biol，2008，254(4)： 861-867.

WANG M L，CAO R Y，ZHANG L K，et al. Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus （2019-nCoV） in vitro[J]. Cell Res，2020，30(3)： 269-271.

DE WIT E，FELDMANN F，CRONIN J，et al. Prophylactic and therapeutic remdesivir （GS-5734） treatment in the rhesus macaque model of MERS-CoV infection[J]. Proc Natl Acad Sci U S A，2020，117(12)： 6771-6776.

CHEN R C，TANG X P，TAN S Y，et al. Treatment of severe acute respiratory syndrome with glucosteroids： the Guangzhou experience[J]. Chest，2006，129(6)： 1441-1452.

LEE N，CHAN K C，HUI D S，et al. Effects of early corticosteroid treatment on plasma SARS-associated Coronavirus RNA concentrations in adult patients[J]. J Clin Virol，2004，31(4)： 304-309.

PLANTONE D，KOUDRIAVTSEVA T. Current and future use of chloroquine and hydroxychloroquine in infectious，immune，neoplastic，and neurological diseases： A mini-review[J]. Clin Drug Investig，2018，38(8)： 653-671.

WANG H L，YANG P，LIU K T，et al. SARS coronavirus entry into host cells through a novel clathrin- and caveolae-independent endocytic pathway[J]. Cell Res，2008，18(2)： 290-301.

HOFFMANN M，KLEINE-WEBER H，SCHROEDER S，et al. SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor[J]. Cell，2020，181(2)： 271-280.

ROSSIGNOL J F. Nitazoxanide，a new drug candidate for the treatment of Middle East respiratory syndrome coronavirus[J]. J Infect Public Health，2016，9(3)： 227-230.

MORGENSTERN B，MICHAELIS M，BAER P C，et al. Ribavirin and interferon-β synergistically inhibit SARS-associated coronavirus replication in animal and human cell lines[J]. Biochem Biophys Res Commun，2005，326(4)： 905-908.

ALFARAJ S H，AL-TAWFIQ J A，ASSIRI A Y，et al. Clinical predictors of mortality of Middle East Respiratory Syndrome Coronavirus （MERS-CoV） infection： A cohort study[J]. Travel Med Infect Dis，2019，29： 48-50.

陈瑞，罗亚萍，徐勋华，等. 武汉地区52例新型冠状病毒肺炎中医证治初探及典型病案分析[J]. 中医杂志，2020，61(9)： 741-744.

张传雷，李彬，李纪高，等. 从中医瘟病理论辨证论治新型冠状病毒肺炎[J]. 中医学报，2020，35(3)： 494-497.

CAO P，WU S L，WU T T，et al. The important role of polysaccharides from a traditional Chinese medicine-Lung Cleansing and Detoxifying Decoction against the COVID-19 pandemic[J]. Carbohydr Polym，2020，240： 116346.

MAITY G N，MAITY P，DASGUPTA A，et al. Structural and antioxidant studies of a new arabinoxylan from green stem Andrographis paniculata （Kalmegh）[J]. Carbohydr Polym，2019，212： 297-303.

LIU J C，SUN Y X，LIU L，et al. A water-soluble polysaccharide （EFP-AW1） from the alkaline extract of the roots of a traditional Chinese medicine，Euphorbia fischeriana： Fraction and characterization[J]. Carbohydr Polym，2012，88(4)： 1299-1303.

CHIHARA G，MAEDA Y，HAMURO J，et al. Inhibition of mouse sarcoma 180 by polysaccharides from Lentinus edodes （Berk.） Sing.[J]. Nature，1969，222(5194)： 687-688.

SHEN L L，DU G. Lycium barbarum polysaccharide stimulates proliferation of MCF-7 cells by the ERK pathway[J]. Life Sci，2012，91(9-10)： 353-357.

XU C，LIU Y，YUAN G，et al. The contribution of side chains to antitumor activity of a polysaccharide from Codonopsis pilosula[J]. Int J Biol Macromol，2012，50(4)： 891-894.

WEI D F，WEI Y X，CHENG W D，et al. Sulfated modification，characterization and antitumor activities of Radix hedysari polysaccharide[J]. Int J Biol Macromol，2012，51(4)： 471-476.

LIU Q Y，YAO Y M，ZHANG S W，et al. Astragalus polysaccharides regulate T cell-mediated immunity via CD11chigh CD45RBlow DCs in vitro[J]. J Ethnopharmacol，2011，136(3)： 457-464.

CHEUNG J K，LI J，CHEUNG A W，et al. Cordysinocan，a polysaccharide isolated from cultured Cordyceps，activates immune responses in cultured T-lymphocytes and macrophages： Signaling cascade and induction of cytokines[J]. J Ethnopharmacol，2009，124(1)： 61-68.

CHENG J，CHAO C，CHANG P，et al. Studies on anti-inflammatory activity of sulfated polysaccharides from cultivated fungi Antrodia cinnamomea [J]. Food Hydrocoll，2014，53： 37-45.

YANG X M，FAN C，GUO N，et al. Preparation of polyporus albicans teng sulfate and its anti-coagulation activity[J]. Chem Res Chin Univ，2010，26(6)： 948-954.

KIM M，YIM J H，KIM S Y，et al. In vitro inhibition of influenza A virus infection by marine microalga-derived sulfated polysaccharide p-KG03 [J]. Antiviral Res，2012，93(2)： 253-259.

WU J J，SHI S S，WANG H J，et al. Mechanisms underlying the effect of polysaccharides in the treatment of type 2 diabetes： A review[J]. Carbohydr Polym，2016，144： 474-494.

RADEMACHER T W，PAREKH R B，DWEK R A. Glycobiology[J]. Annu Rev Biochem，1988，57(1)： 785-838.

ZENG H，HUANG L L，TAO H，et al. Structural elucidation of a pectin from roots of Polygala tenuifolia and its neuritogenesis inducing activity in PC12 cells [J]. Carbohydr Polym，2020，236： 116048.

LI M X，YUE H，WANG Y Q，et al. Intestinal microbes derived butyrate is related to the immunomodulatory activities of Dendrobium officinale polysaccharide [J]. Int J Biol Macromol，2020，149： 717-723.

YAO Y L，ZHOU L S，LIAO W F，et al. HH1-1，a novel Galectin-3 inhibitor，exerts anti-pancreatic cancer activity by blocking Galectin-3/EGFR/AKT/FOXO3 signaling pathway[J]. Carbohydr Polym，2019，204： 111-123.

ZHANG L，WANG P P，QIN Y，et al. RN1，a novel galectin-3 inhibitor，inhibits pancreatic cancer cell growth in vitro and in vivo via blocking galectin-3 associated signaling pathways [J]. Oncogene，2017，36(9)： 1476-5594.

MURALIDHARAN A，RUSSELL M S，LAROCQUE L，et al. Chitosan alters inactivated respiratory syncytial virus vaccine elicited immune responses without affecting lung histopathology in mice[J]. Vaccine，2019，37(30)： 4031-4039.

FENG H B，FAN J，YANG S P，et al. Antiviral activity of phosphorylated Radix Cyathulae officinalis polysaccharide against Canine Parvovirus in vitro [J]. Int J Biol Macromol，2017，99： 511-518.

杭传珍. 中医扶正固本治则的药理学基础[J]. 长春中医学院学报，2001，17(1)： 63-64.

CHENG D Q，SUN L，ZOU S Y，et al. Antiviral Effects of Houttuynia cordata Polysaccharide Extract on Murine Norovirus-1 （MNV-1）－A Human Norovirus Surrogate[J]. Molecules，2019，24(9)： 1835.

ZHAO X N，LIU J Z. Scutellaria polysaccharide inhibits the infectivity of Newcastle disease virus to chicken embryo fibroblast [J]. J Sci Food Agric，2014，94(4)： 779-784.

ZHANG J，HU Y L，WANG D Y，et al. The optimization of sulfation modification conditions for ophiopogonpolysaccharide based on antiviral activity[J]. Int J Biol Macromol，2012，51(4)： 657-662.

ZHAO X N，HU Y L，WANG D Y，et al. Optimization of sulfated modification conditions of tremella polysaccharide and effects of modifiers on cellular infectivity of NDV[J]. Int J Biol Macromol，2011，49(1)： 44-49.

WANG J M，HU Y L，WANG D Y，et al. Lycium barbarum polysaccharide inhibits the infectivity of Newcastle disease virus to chicken embryo fibroblast[J]. Int J Biol Macromol，2010，46(2)： 212-216.

LANG J S，YANG N，DENG J J，et al. Inhibition of SARS pseudovirus cell entry by lactoferrin binding to heparan sulfate proteoglycans[J]. PLoS One，2011，6(8)： e23710.

CLAUSEN T M，SANDOVAL D R，SPLIID C B，et al. SARS-CoV-2 infection depends on cellular heparan sulfate and ACE2[J]. Cell，2020，183(4)： 1043-1057.

HUANG C C，TANG M，ZHANG M Y，et al. Structure of a V3-containing HIV-1 gp120 core[J]. Science，2005，310(5750)： 1025-1028.

MATROSOVICH M，HERRLER G，KLENK H D. Sialic Acid Receptors of Viruses[J]. Top Curr Chem，2015，367： 1-28.

BURZYŃSKA P，SOBALA Ł F，MIKOŁAJCZYK K，et al. Sialic Acids as Receptors for Pathogens[J]. Biomolecules，2021，11(6)： 831.

LAURIENZO P. Marine polysaccharides in pharmaceutical applications： An overview [J]. Marine Drugs，2010，8(9)： 2435-2465.

ANDREW M，JAYARAMAN G. Marine sulfated polysaccharides as potential antiviral drug candidates to treat Corona Virus disease（COVID-19）[J]. Carbohydr Res，2021，505： 108326.

CHATTOPADHYAY K，MATEU C G，MANDAL P，et al. Galactan sulfate of Grateloupia indica： Isolation，structural features and antiviral activity [J]. Phytochemistry，2007，68(10)： 1428-1435.

PUJOL C A，RAY S，RAY B，et al. Antiviral activity against dengue virus of diverse classes of algal sulfated polysaccharides [J]. Int J Biol Macromol，2012，51(4)： 412-416.

TUVAANJAV S，SHUQIN H，KOMATA M，et al. Isolation and antiviral activity of water-soluble Cynomorium songaricum Rupr. polysaccharides[J]. J Asian Nat Prod Res，2016，18(2)： 159-171.

KONG W J，ZHAO Y L，SHAN L M，et al. Thermochemical studies on the quantity-antibacterial effect relationship of four organic acids from Radix Isatidis on Escherichia coli growth[J]. Biol Pharm Bull，2008，31(7)： 1301-1305.

WANG C M，RUAN S M，GU X M，et al. Antiviral activities of Radix Isatidis polysaccharide against type Ⅱ herpes simplex virus in vitro[J]. Food Sci Technol，2018，38： 180-183.

WEI K，SUN Z，YAN Z，et al. Effects of Taishan Pinus massoniana pollen polysaccharide on immune response of rabbit haemorrhagic disease tissue inactivated vaccine and on production performance of Rex rabbits [J]. Vaccine，2011，29(14)： 2530-2536.

YU C，WEI K，LIU L，et al. Taishan Pinus massoniana pollen polysaccharide inhibits subgroup J avian leucosis virus infection by directly blocking virus infection and improving immunity[J]. Sci Rep，2017，7： 44353.

DING K，ZHANG B，CHEN X，et al. Structural characterization of cocktail-like targeting polysaccharides from Ecklonia kurome Okam and their anti-SARS-CoV-2 activities in vitro[J]. bioRxiv，2021. doi：10.1101/2021.01.14.426521http://doi.org/ 10.1101/2021.01.14.426521.

CHEN Y，LUO Q Y，LI S M，et al. Antiviral activity against porcine epidemic diarrhea virus of Pogostemon cablin polysaccharide[J]. J Ethnopharmacol，2020，259： 113009.

WEI Z Y，WANG X B，ZHANG H Y，et al. Inhibitory effects of indigowoad root polysaccharides on porcine reproductive and respiratory syndrome virus replication in vitro[J]. Antivir Ther，2011，16(3)： 357-363.

THAKUR A，MIKKELSEN H，JUNGERSEN G. Intracellular pathogens： Host immunity and microbial persistence strategies[J]. J Immunol Res，2019，2019： 1356540.

WONG J，CHOI S Y C，LIU R R，et al. Potential Therapies for Infectious Diseases Based on Targeting Immune Evasion Mechanisms That Pathogens Have in Common With Cancer Cells [J]. Front Cell Infect Microbiol，2019，9： 25.

CHEN N S，ZHOU M，DONG X，et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan，China： a descriptive study [J]. Lancet，2020，395(10223)： 507-513.

ALTAN-BONNET G，MUKHERJEE R. Cytokine-mediated communication： a quantitative appraisal of immune complexity[J]. Nat Rev Immunol，2019，19(4)： 205-217.

XIE S Z，HAO R，ZHA X Q，et al. Polysaccharide of Dendrobium huoshanense activates macrophages via toll-like receptor 4-mediated signaling pathways[J]. Carbohydr Polym，2016，146： 292-300.

REN G M，XU L M，LU T Y，et al. Structural characterization and antiviral activity of lentinan from Lentinus edodes mycelia against infectious hematopoietic necrosis virus[J]. Int J Biol Macromol，2018，115： 1202-1210.

HAGIHARA K，YAKUBO S，NAMIKI T，et al. Abbreviation of kampo formulations and basic terminology in kampo medicine[J]. Tradit Kampo Med，2017，4(2)： 65-88.

LEE J B，FUKAI T，HAYASHI K，et al. Characterization of fructan from Chikuyo-Sekko-To，a Kampo prescription，and its antiherpetic activity in vitro and in vivo [J]. Carbohydr Polym，2011，85(2)： 408-412.

CHEN X Y，HAN W W，WANG G X，et al. Application prospect of polysaccharides in the development of anti-novel coronavirus drugs and vaccines[J]. Int J Biol Macromol，2020，164： 331-343.

CHEN Y，WU Y，XIAN L T，et al. Effects of Bush Sophora Root polysaccharide and its sulfate on immuno-enhancing of the therapeutic DVH[J]. Int J Biol Macromol，2015，80： 217-224.

SONG X，ZHANG Y T，YIN Z Q，et al. Antiviral effect of sulfated Chuanmingshen violaceum polysaccharide in chickens infected with virulent Newcastle disease virus [J]. Virology，2015，476： 316-322.

WU Y J，LI S，LI H X，et al. Effect of a polysaccharide from Poria cocos on humoral response in mice immunized by H1N1 influenza and HBsAg vaccines [J]. Int J Biol Macromol，2016，91： 248-257.

HUANG Y，LIU Z G，BO R N，et al. The enhanced immune response of PCV-2 vaccine using Rehmannia glutinosa polysaccharide liposome as an adjuvant[J]. Int J Biol Macromol，2016，86： 929-936.

BO R N，ZHENG S S，XING J，et al. The immunological activity of Lycium barbarum polysaccharides liposome in vitro and adjuvanticity against PCV2 in vivo[J]. Int J Biol Macromol，2016，85： 294-301.

MANGALMURTI N，HUNTER C A. Cytokine storms： understanding COVID-19[J]. Immunity，2020，53(1)： 19-25.

FORRESTER S J，KIKUCHI D S，HERNANDES M S，et al. Reactive oxygen species in metabolic and inflammatory signaling [J]. Circ Res，2018，122(6)： 877-902.

KRUK J，ABOUL-ENEIN H Y，KŁADNA A，et al. Oxidative stress in biological systems and its relation with pathophysiological functions： the effect of physical activity on cellular redox homeostasis[J]. Free Radic Res，2019，53(5)： 497-521.

AHMAD A，AHSAN H. Biomarkers of inflammation and oxidative stress in ophthalmic disorders[J]. J Immunoassay Immunochem，2020，41(3)： 257-271.

LI Z T，LI L，ZHOU H X，et al. Radix isatidis polysaccharides inhibit influenza A virus and influenza A virus-induced inflammation via suppression of host TLR3 signaling in vitro[J]. Molecules，2017，22(1)： 116.

WANG T B，WANG X W，ZHUO Y，et al. Antiviral activity of a polysaccharide from Radix Isatidis （Isatis indigotica Fortune） against hepatitis B virus （HBV） in vitro via activation of JAK/STAT signal pathway[J]. J Ethnopharmacol，2020，257： 112782.

XUE H X，GAN F，ZHANG Z Q，et al. Astragalus polysaccharides inhibits PCV2 replication by inhibiting oxidative stress and blocking NF-κB pathway [J]. Int J Biol Macromol，2015，81： 22-30.

SONG M Y，CHEN Y，DU H X，et al. Raw rehmannia radix polysaccharide can effectively release peroxidative injury induced by duck hepatitis a virus [J]. Afr J Tradit Complement Altern Med，2017，14(4)： 8-21.

CHEN Y，XIONG W，ZENG L，et al. Bush Sophora Root polysaccharide and its sulfate can scavenge free radicals resulted from duck virus hepatitis[J]. Int J Biol Macromol，2014，66： 186-193.

KOH A，BÄCKHED F. From association to causality： the role of the gut microbiota and its functional products on host metabolism [J]. Mol Cell，2020，78(4)： 584-596.

HELMINK B A，KHAN M A W，HERMANN A，et al. The microbiome，cancer，and cancer therapy[J]. Nat Med，2019，25(3)： 377-388.

STEFAN K L，KIM M V，IWASAKI A，et al. Commensal microbiota modulation of natural resistance to virus infection[J]. Cell，2020，183(5)： 1312-1324.

KUANG H X，XIA Y G，YANG B Y，et al. Screening and comparison of the immunosuppressive activities of polysaccharides from the stems of Ephedra sinica Stapf [J]. Carbohydr Polym，2011，83(2)： 787-795.

LIN X T，LIANG S S，WANG Q H，et al. Metagenomics approach the intestinal microbiome structure and function in the anti-H1N1 of a traditional chinese medicine acid polysaccharide[J]. Microb Pathog，2020，147： 104351.

SHANG H Q，SHA Z，WANG H，et al. Taishan Pinus massoniana pollen polysaccharide inhibits H9N2 subtype influenza virus infection both in vitro and in vivo [J]. Vet Microbiol，2020，248： 108803.

Views

1457

下载量

CSCD

CNKI被引量

Alert me when the article has been cited

提交

Tools

Publicity Resources

Research progress on pharmacological activity and mechanism of timosaponin B-Ⅱ

Research progress of Tripterygium wilfordii in treating psoriatic arthritis

Research Advances in mechanisms of Rehmanniae Radix Praeparata and Acori Tatarinowii Rhizoma in prevention and treatment of Alzheimer’s disease

Research progress on pharmacological mechanism of Gastrodiae Rhizoma in cardiovascular and metabolic diseases

Research progress on mechanisms of m⁶A RNA methylated modification regulating non⁃small cell lung cancer

Related Author

No data

Related Institution

Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University

People’s Hospital of Ningling County

Henan Ke Laboratory of Precision Clinical Pharmacy

Shanghai University of Traditional Chinese Medicine

Second Department of Arthrology,Shanghai Guanghua Hospital of Integrated Traditional Chinese and Western Medicine

⁰