Current situation and thinking of network pharmacology in the research of traditional Chinese medicine

CHEN Jian; CHEN Qilong

doi:10.16306/j.1008-861x.2021.05.001

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Current situation and thinking of network pharmacology in the research of traditional Chinese medicine

Scholar Forum | 更新时间：2022-09-09

- Current situation and thinking of network pharmacology in the research of traditional Chinese medicine
- Academic Journal of Shanghai University of Traditional Chinese Medicine Vol. 35, Issue 5, Pages: 1-6,13(2021)
- 作者机构：
  
  1.上海中医药大学交叉科学研究院（上海　201203）
  2.上海中医药大学附属上海市中西医结合医院（上海　200082）
- 作者简介：
- 基金信息：
- DOI：10.16306/j.1008-861x.2021.05.001
  CLC：
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CHEN Jian, CHEN Qilong. Current situation and thinking of network pharmacology in the research of traditional Chinese medicine. [J]. Academic Journal of Shanghai University of Traditional Chinese Medicine 35(5):1-6,13(2021)
DOI：

CHEN Jian, CHEN Qilong. Current situation and thinking of network pharmacology in the research of traditional Chinese medicine. [J]. Academic Journal of Shanghai University of Traditional Chinese Medicine 35(5):1-6,13(2021) DOI： 10.16306/j.1008-861x.2021.05.001.

摘要

网络药理学已成为中医药药理基础与作用机制研究的热门工具，广泛应用于中药活性成分筛选、药物重定位、中药配伍机制探索及中医药多成分、多靶点、多通路的作用机制阐释等。回顾网络药理学的发展历程，整理现阶段网络药理学相关的中医药数据库、疾病数据库、功能注释数据库，对网络药理学在中医药现代化研究中的应用进行简要综述，并指出研究中面临的问题及挑战，进而展望中医药网络药理学研究的发展方向，以期为规范、合理使用网络药理学进行中医药研究提供指导，同时也为引领中医药原创研究的发展以及中药新药研发提供思路。

Abstract

Network pharmacology has become a popular tool for the research on pharmacological basis and action mechanism of traditional Chinese medicine(TCM) .It is widely used in the screening of active components of Chinese medicines, repositioning of drugs, exploration of the mechanism of compatibility of Chinese medicines, and explanation of the action mechanism of multi-components, multi-targets and multi-pathways of Chinese medicines.The development stages of network pharmacology are reviewed, the databases related to network pharmacology at the present stage, such as TCM database, disease database and functional annotation database, are sorted out, and the application of network pharmacology in the research of TCM modernization is briefly summarized.It also points out the problems and challenges of network pharmacology research, and then looks forward to the development direction of TCM network pharmacology research.The purpose of this paper is to provide guidance for standardized and rational application of network pharmacology in TCM research, and provide ideas for leading the development of TCM original researches and the research and development of new Chinese medicines.

关键词

网络药理学中医药数据库

Keywords

network pharmacologytraditional Chinese medicinedatabase

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