Objective:,2,To compare the clinical efficacy between lift-up submucosal hemorrhoidectomy and traditional Milligan-Morgan hemorrhoidectomy in the treatment of annular mixed hemorrhoids.,Methods:,2,A total of 90 patients with annular mixed hemorrhoids were included and randomly divided into the treatment group and control group, 45 cases in each group.The patients in the treatment group were treated with therapy of lift-up submucosal hemorrhoidectomy, and the patients in the control group were treated with therapy of Milligan-Morgan hemorrhoidectomy.Three months after operation, the clinical efficacy of the two groups were evaluated and compared.On the 1st, 3rd, 7th and 14th days after operation, the scores of anal pain, bleeding, wound edema, anal distension and defecation were evaluated.Three months after operation, the Wexner scale was applied to evaluate the anal function, and the indexes of anorectal pressure including rectal resting pressure, anal resting pressure and maximal anal contraction pressure were detected.The operation time, hospitalization time, wound healing time and hospitalization cost of the two groups were compared.,Results:,2,①Three months after operation, the clinical total effective rates of the two groups were 100%, with no statistically significant difference between the two groups(,P,>,0.05) .②On the 1st, 3rd, 7th and 14th days after operation, the score of anal pain in the treatment group was lower than that in the control group(,P,<,0.05,P,<,0.01) .On the 1st, 3rd and 7th days after operation, the scores of bleeding and anal distension in the treatment group were lower than those in the control group(,P,<,0.05,P,<,0.01) .On the 3rd day after operation, the score of wound edema in the treatment group was also lower than that in the control group(,P,<,0.05) .③Three months after operation, the anal resting pressure in the treatment group was significantly lower than that in the control group(,P,<,0.01) .④The operation time, hospitalization time and wound healing time in the treatment group were significantly shorter than those in the control group(,P,<,0.01), and the hospitalization cost was significantly less than that in the control group(,P,<,0.01) .,Conclusion:,2,Compared with Milligan-Morgan hemorrhoidectomy, lift-up submucosal hemorrhoidectomy shows good clinical efficacy in the treatment of annular mixed hemorrhoids, and can effectively alleviate the symptoms such as postoperative pain, bleeding, wound edema and anal distension, and restore the anal function, with good economy.