上海中医药大学(上海 201203)
明珍,女,在读硕士生,主要从事本草文献学研究
杨熠文,副教授,硕士生导师;E-mail:yywchelsea@qq.com
收稿:2025-03-20,
修回:2025-07-17,
纸质出版:2026-04-25
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明珍,张亭立,杨柏灿等.本草药理发展沿革中的内涵演变与探析[J].上海中医药大学学报,2026,40(02):8-15.
MING Zhen,ZHANG Tingli,YANG Baican,et al.Connotation evolution and analysis in development of herbal pharmacology[J].Academic Journal of Shanghai University of Traditional Chinese Medicine,2026,40(02):8-15.
明珍,张亭立,杨柏灿等.本草药理发展沿革中的内涵演变与探析[J].上海中医药大学学报,2026,40(02):8-15. DOI: 10.16306/j.1008-861x.2026.02.002.
MING Zhen,ZHANG Tingli,YANG Baican,et al.Connotation evolution and analysis in development of herbal pharmacology[J].Academic Journal of Shanghai University of Traditional Chinese Medicine,2026,40(02):8-15. DOI: 10.16306/j.1008-861x.2026.02.002.
“中药药理”常被视作现代中药研究的专属范畴。追溯历史,早在《本草经集注》中就有“药理”之名,经过历代医药学家的完善与补充,构建了系统的中药药理体系,该体系被命名为“本草药理”。本草药理发展的历史沿革始终与中华古代文明及社会进程保持同步,展现出与时俱进的时代特征,可划分为萌芽起源期、形成期、发展期与转型分化期,分别以药性药理、法象药理、综合药理、成分药理为标志。由此,本草药理可被界定为一门建立在中国古代哲学思想与医学理论基础上,以临床应用为导向,从药源、药性、药用、成分等多维度综合性阐释中药的药效与主治的药学理论。通过本草药理对药物认识的整体框架,能够实现对现代多角度研究结果的整合,搭建起化学成分与药效之间的桥梁,使研究能够更精准地识别中药有效成分,深入探究中药成分与药效间的复杂关系,为从现代角度阐释药物提供全面且深入的视角,并最终服务于临床用药。
The "traditional Chinese medicine (TCM) pharmacology" is often regarded as the exclusive category of modern research on TCM. Tracing back in history, the terminological precursor "yaoli (药理)" was already mentioned in
Commentary on the Classic of Materia Medica.
Through the refinement and supplementation of medical scholars of successive dynasties, a systematic pharmacological framework for TCM was established, termed "Bencao Pharmacology" (Pharmacology of Chinese Herbal Medicine). In parallel with the evolution of Chinese civilization and sociocultural thought, this intellectual tradition developed through four paradigmatic stages: a nascent stage emphasizing property-driven pharmacodynamics; an institutional stage anchored in the doctrine of symbolic analogy; a mature stage characterized by holistic therapeutic reasoning; and a transformative stage oriented toward component-based analysis. Conceived as such, Bencao Pharmacology constitutes a clinical discipline deeply rooted in classical Chinese metaphysical frameworks and medical epistemology. It integrates botanical provenance, inherent properties, therapeutic functions, and material composition into a multidimensional cartography of efficacy and indication. Through the holistic framework of Bencao Pharmacology, the integra
tion of modern multi-angle research results can be realized, bridging chemical components and therapeutic effects in modern studies. It enables modern research to identify the active ingredients of Chinese medicine more accurately, explores the complex relationship between the components and the efficacy of Chinese medicine in depth, and provides a comprehensive and in-depth perspective for the interpretation of drugs from a modern perspective, and ultimately serves clinical practice.
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